Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yangshan Chen"'
Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice
Autor:
Xiaoting Hou, Yangshan Chen, Bo Zhou, Wanze Tang, Zhen Ding, Litong Chen, Yun Wu, Hongyu Yang, Changzheng Du, Dazhi Yang, Guixing Ma, Huiling Cao
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-15 (2023)
Abstract Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate the high expression of Talin-1 in β-cells and that deficiency of Talin-1 reduces β-cell p
Externí odkaz:
https://doaj.org/article/88d11d960bee4ec2b815b2aaa6a84424
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 3963-3987 (2023)
The ubiquitin–proteasome system (UPS) dedicates to degrade intracellular proteins to modulate demic homeostasis and functions of organisms. These enzymatic cascades mark and modifies target proteins diversly through covalently binding ubiquitin mol
Externí odkaz:
https://doaj.org/article/9ca866c38339489fbb476aed20a9aab0
Autor:
Huan Yang, Lili Chen, Zhiqiang Cheng, Minglei Yang, Jianbo Wang, Chenghao Lin, Yuefeng Wang, Leilei Huang, Yangshan Chen, Sui Peng, Zunfu Ke, Weizhong Li
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Targeted therapy and immunotherapy put forward higher demands for accurate lung cancer classification, as well as benign versus malignant disease discrimination. Digital whole slide images (WSIs) witnessed the transition from trad
Externí odkaz:
https://doaj.org/article/c926df78fcd5460bacc79e0277f19284
Autor:
Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang, Wenting Jiang, Han Wang, Lili Chen, Jiping Luo, Yanyang Chen, Kejing Tang, Chengzhi Zhou, Zunfu Ke
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients. Methods A total of 210 LUAD patients diagnosed between 2003
Externí odkaz:
https://doaj.org/article/a7d8a7a95e7342d4a0913b54b9d9ba9e
Autor:
Kejing Tang, Neng Jiang, Yukun Kuang, Qiong He, Shuhua Li, Jiping Luo, Wenting Jiang, Yangshan Chen, Yu Sun, Lili Chen, Yanyang Chen, Junfeng Zhu, Yongmei Cui, Han Wan, Zunfu Ke
Publikováno v:
Thoracic Cancer, Vol 10, Iss 2, Pp 359-364 (2019)
A large number of EGFR mutant non‐small cell lung cancer patients primordially benefit from first‐line treatment with first‐generation EGFR‐tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. However, multiple acquired resista
Externí odkaz:
https://doaj.org/article/a58d31ca362a4305b64dc8bbb6d36225
Autor:
Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang, Zun-fu Ke
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Circulating tumor cells (CTC) shows great prospect to realize precision medicine in cancer patients. Methods We developed the NanoVelcro Chip integrating three functional mechanisms. NanoVelcro CTC capture efficiency was tested in
Externí odkaz:
https://doaj.org/article/28239f69a35b42aa83356c705a011211
Autor:
Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion. The object of this s
Externí odkaz:
https://doaj.org/article/92117b7106464fa68711bd6d72eb305a
Autor:
Zunfu Ke, Liantang Wang, Xuenong Zou, Jianhong Wang, Chunlin Wang, Chenzhi Zhou, Honglei Chen, Millicent Lin, Yang Zhang, Jianwen Zhou, Qiong He, Shuhua Li, Yingrong Lai, Han Wang, Yangshan Chen, Yu Sun, Neng Jiang, Wenting Jiang, Yuxin Zhu, Wenhui Zhang, Cuilan Tang, Di Xu, Lili Chen, Hui Zhang, Ming Kuang, Sui Peng, Weiling He, Yiyan Lei, Jian Zhang, Kejing Tang, Chaofeng Li, Wenfeng Fang, Yongmei Cui
Supplementary Table S1 shows the list of primary antibodies used for immunohistochemical staining and immunoblotting assays. Supplementary Table S2 shows the clinical characteristics of 626"driver-gene-negative" LUAD patients from four cohorts. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff81ef6aec5bb559fb3dee54f5afa0e
https://doi.org/10.1158/1078-0432.22470896
https://doi.org/10.1158/1078-0432.22470896
Autor:
Zunfu Ke, Liantang Wang, Xuenong Zou, Jianhong Wang, Chunlin Wang, Chenzhi Zhou, Honglei Chen, Millicent Lin, Yang Zhang, Jianwen Zhou, Qiong He, Shuhua Li, Yingrong Lai, Han Wang, Yangshan Chen, Yu Sun, Neng Jiang, Wenting Jiang, Yuxin Zhu, Wenhui Zhang, Cuilan Tang, Di Xu, Lili Chen, Hui Zhang, Ming Kuang, Sui Peng, Weiling He, Yiyan Lei, Jian Zhang, Kejing Tang, Chaofeng Li, Wenfeng Fang, Yongmei Cui
Purpose:Examining the role of developmental signaling pathways in “driver gene–negative” lung adenocarcinoma (patients with lung adenocarcinoma negative for EGFR, KRAS, BRAF, HER2, MET, ALK, RET, and ROS1 were identified as “driver gene–neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eec05c090a21dca4392283cef93747e
https://doi.org/10.1158/1078-0432.c.6527720
https://doi.org/10.1158/1078-0432.c.6527720
Autor:
Yanyang, Chen, Huan, Yang, Zhiqiang, Cheng, Lili, Chen, Sui, Peng, Jianbo, Wang, Minglei, Yang, Chenghao, Lin, Yu, Chen, Yuefeng, Wang, Leilei, Huang, Yangshan, Chen, Weizhong, Li, Zunfu, Ke
Publikováno v:
Lung Cancer. 165:18-27
Clinically, accurate pathological diagnosis is often challenged by insufficient tissue amounts and the unaffordability of additional immunohistochemical or genetic tests; thus, there is an urgent need for a universal approach to improve the subtyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12be477ec99fa3d1ff7cb1f77ffeef16
https://doi.org/10.1016/j.lungcan.2022.01.005
https://doi.org/10.1016/j.lungcan.2022.01.005