Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Yangping Shentu"'
Autor:
Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu, Zhiqian Tong
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1133 (2023)
Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein. However, the developed medicines tar
Externí odkaz:
https://doaj.org/article/bd19586bdf2c4cc980983afa6583f506
Autor:
Yangping Shentu, Huanchang Jiang, Xiaoyuan Liu, Hao Chen, Dicheng Yang, Jinqi Zhang, Chen Cheng, Yulin Zheng, Yang Zhang, Chaosheng Chen, Chenfei Zheng, Ying Zhou
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundPeritoneal dialysis (PD) is a treatment for end stage renal disease patients, but it can also cause peritoneal fibrosis. Nestin is known as a neural stem cell marker and it has many functions. The hypoxia induced factor (HIF) signaling path
Externí odkaz:
https://doaj.org/article/f96b748be18342a6a143b18fd702d3dc
Autor:
Qing Zhang, Yiyuan Xia, Hongbin Luo, Sheng Huang, Yongjun Wang, Yangping Shentu, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiaochuan Wang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Codonopsis pilosula polysaccharide (CPPs), a natural products with potentially lower toxicity and better bioavailability has been used in traditional Chinese medicine for 1000s of years and a neuroprotective polysaccharide mitigates tau pathology in
Externí odkaz:
https://doaj.org/article/ae0d9bd6b2d34b0da675b6a8070d53aa
Autor:
Qing Zhang, Yiyuan Xia, Yongjun Wang, Yangping Shentu, Kuan Zeng, Yacoubou A. R. Mahaman, Fang Huang, Mengjuan Wu, Dan Ke, Qun Wang, Bin Zhang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, Xiaochuan Wang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and is associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation in AD. However, whether CK2 phosphorylates SE
Externí odkaz:
https://doaj.org/article/3c6a45a20fcc41b3bd8427bb9f85d077
Autor:
Wenting Hu, Zhuoqun Wang, Huiliang Zhang, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dongli Meng, Ying Zhou, Shiyi Wang, Nan Jiang, Jing Xiong, Jukka Westermarck, Youming Lu, Jianzhi Wang, Xiaochuan Wang, Yangping Shentu, Rong Liu
Publikováno v:
Neurotherapeutics. 19:570-591
Alzheimer’s disease (AD) is the most common neurodegenerative disease with limited therapeutic strategies. Cell cycle checkpoint protein kinase 1 (Chk1) is a Ser/Thr protein kinase which is activated in response to DNA damage, the latter which is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d191443ea573b1acf6c0ac1eafcb0b
https://doi.org/10.1007/s13311-022-01204-z
https://doi.org/10.1007/s13311-022-01204-z
Publikováno v:
Brain Research Bulletin. 164:172-183
Epidemiological and experimental animal studies indicate that there is a high risk for the incidence of neuropsychiatric disorders suffering from cardiovascular diseases such as myocardial infarction (MI). However, the potential mechanism of this ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c97511b71625101b34d0d9dddba000b
https://doi.org/10.1016/j.brainresbull.2020.08.023
https://doi.org/10.1016/j.brainresbull.2020.08.023
Autor:
Xiaoyuan Liu, Ying Zhou, Dichen Yang, Xingzhou Huang, Nan Jiang, Shuqing Ma, Shuangshuang Song, Yongsheng Gong, Huanchang Jiang, Jun Ma, Chaosheng Chen, Xiaochuan Wang, Junming Fan, Chenfei Zheng, Yangping Shentu, Kate Huang, Zhongyuan Zhao, Rong Liu, Hao Chen, Simin Ye, Xiaofang Fan
Publikováno v:
The FASEB Journal. 34:16414-16431
Polyphyllin I (PPI) is a natural phytochemical drug isolated from plants which can inhibit the proliferation of cancer cells. One of the PPI tumor-inhibitory effects is through downregulating the expression of Cancerous Inhibitor of PP2A (CIP2A), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ce9de5bd80de5f8f9cb509c68f3fd3
https://doi.org/10.1096/fj.202001499r
https://doi.org/10.1096/fj.202001499r
Autor:
Ying Zhou, Xiaoyuan Liu, Shuqing Ma, Nan Zhang, Dichen Yang, Ling Wang, Simin Ye, Qiongying Zhang, Jing Ruan, Jun Ma, Shiyi Wang, Nan Jiang, Zongyuan Zhao, Shujue Zhao, Chenfei Zheng, Xiaofang Fan, Yongsheng Gong, Mahaman Yacoubou Abdoul Razak, Wenting Hu, Jingye Pan, Xiaochuan Wang, Junming Fan, Jianmin Li, Rong Liu, Yangping Shentu
Publikováno v:
The FASEB Journal. 36
Cancerous Inhibitor of PP2A (CIP2A), an endogenous PP2A inhibitor, is upregulated and causes reactive astrogliosis, synaptic degeneration, and cognitive deficits in Alzheimer's disease (AD). However, the mechanism underlying the increased CIP2A expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e20079df2bcedcfd0a26646d6e361b
https://doi.org/10.1096/fj.202101625r
https://doi.org/10.1096/fj.202101625r
Autor:
Nan, Zhang, Yangping, Shentu, Min, Zhu, Hui, Wang, Xianghong, Yin, Congkuo, Du, Feng, Xue, Junming, Fan, Yongsheng, Gong, Xiaofang, Fan
Publikováno v:
Brain Research. 1797:148117
Recent reports suggested the endoplasmic reticulum stress (ERS)-associated pathway is involved with cognitive impairment in hypoxia condition. ERO1-like protein alpha (Ero1α), an endoplasmic reticulum membrane-bound N-glycoprotein, has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd468e0b635e17fb495218c1e65e50dc
https://doi.org/10.1016/j.brainres.2022.148117
https://doi.org/10.1016/j.brainres.2022.148117
Autor:
Qiongying Zhang, Xiaofang Fan, Junming Fan, Shiyi Wang, Simin Ye, Xiaoyuan Liu, Jianmin Li, Shujue Zhao, Nan Jiang, Nan Zhang, Rong Liu, Yongsheng Gong, Yangping Shentu, Jun Ma, Zongyuan Zhao, Chenfei Zheng, Ying Zhou, Shuqing Ma, Dichen Yang, Xiaochuan Wang, Jing Ruan
Background: In Alzheimer’s disease (AD), activation of astrocyte participates in the development of neurodegenerative diseases through neuroinflammation and disturbs glia-neuron interaction. Cancerous Inhibitor of PP2A (CIP2A) is an endogenous PP2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4cd8acce5700978b7e9f1f79a08fe6b
https://doi.org/10.21203/rs.3.rs-877963/v1
https://doi.org/10.21203/rs.3.rs-877963/v1
