Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Yangliu Xia"'
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-14 (2021)
Abstract Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent. Whether and how WA improves D-galactosamine (GalN)/lipo
Externí odkaz:
https://doaj.org/article/4193d873f1364a1188d355de77ca2472
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 3-18 (2020)
Few medications are available for meeting the increasing disease burden of nonalcoholic fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH). Traditional herbal medicines (THM) have been used for centuries to tre
Externí odkaz:
https://doaj.org/article/86bb8b50fdbb48a097889cedb88f75e8
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 258-278 (2019)
Uridine-diphosphate glucuronosyltransferase 1A1 (UGT1A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1A1 may trigger adv
Externí odkaz:
https://doaj.org/article/a914c1c47cfa4fcd92e9483bfd92eb24
Publikováno v:
Molecules, Vol 23, Iss 10, p 2476 (2018)
In this study, daphnetin 1 was chosen as the lead compound, and C-3 or C-4-substituted daphnetins were designed and synthesized to explore the potential relationship between the antioxidant activities and the chemical structures of daphnetin derivati
Externí odkaz:
https://doaj.org/article/9d27631d3a87451fafe75aedcea2c2b0
Autor:
Zhen, Wang, Zhe, Wang, Xiaoyu, Wang, Xin, Lv, Hang, Yin, Xiaoyu, Fan, Mingrui, Yan, Yanyan, Jia, Lili, Jiang, Yangliu, Xia, Wenli, Li, Yong, Liu
Publikováno v:
Toxicology Letters. 367:3-8
Catechol-O-methyltransferase (COMT) inhibitors are widely used as an add-on treatment to levodopa in adults with Parkinson's disease. It has been evidenced that the second-generation COMT inhibitors entacapone and tolcapone are potent inhibitors on h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95d73066b93d49cfaf3af18c63dcc0d
https://doi.org/10.1016/j.toxlet.2022.07.003
https://doi.org/10.1016/j.toxlet.2022.07.003
Publikováno v:
Toxicology and Applied Pharmacology. 466:116490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6014513d82b8d72cbaa65634482670
https://doi.org/10.1016/j.taap.2023.116490
https://doi.org/10.1016/j.taap.2023.116490
Autor:
Ling Yang, Yangliu Xia, Dong-Fang Zhao, Yu-Fan Fan, Ping Wang, Fang-Yuan Wang, Frank J. Gonzalez, Guang-Bo Ge
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 11, Iss 1, Pp 15-27 (2021)
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis
Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92383b44e068d84760b715a43c9195fd
http://www.sciencedirect.com/science/article/pii/S2095177919309931
http://www.sciencedirect.com/science/article/pii/S2095177919309931
Autor:
Shi-Yang Li, Yangliu Xia, Frank J. Gonzalez, Ling Yang, Dong-Fang Zhao, Fan-Bin Hou, Ping Wang, Yu-Fan Fan, Fang-Yuan Wang, Guang-Bo Ge
Publikováno v:
RSC Advances. 11:10385-10392
Human catechol-O-methyltransferase (hCOMT) is considered a therapeutic target due to its crucial roles in the metabolic inactivation of endogenous neurotransmitters and xenobiotic drugs. There are nevertheless few safe and effective COMT inhibitors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a138c9dcd9adf38789a91bfa66d24e70
https://doi.org/10.1039/d0ra10425f
https://doi.org/10.1039/d0ra10425f
Autor:
Zhen Wang, Zhe Wang, Xiaoyu Wang, Xin Lv, Hang Yin, Lili Jiang, Yangliu Xia, Wei Li, Wenli Li, Yong Liu
Publikováno v:
Chemico-biological interactions. 365
Thymoquinone, predominant bioactive compound in Nigella sativa L. (N.sativa) oil, may inhibit the activity of cytochrome P450 2C9 (CYP2C9). However, it is not clear whether thymoquinone can affect the pharmacokinetic behavior of warfarin. Thus, we fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f7cfd078a804527113a1e90971496f
https://pubmed.ncbi.nlm.nih.gov/35921950
https://pubmed.ncbi.nlm.nih.gov/35921950
Autor:
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Peroxisome proliferator-activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a566d0ee9752987b92502e8eb67d9aa
https://pubmed.ncbi.nlm.nih.gov/35460276
https://pubmed.ncbi.nlm.nih.gov/35460276