Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yangjin Zuo"'
Autor:
Xiuqin Bao, Yuanyi Gao, Zhongju Wang, Yuhua Ye, Diyu Chen, Yangjin Zuo, Cunyou Zhao, Xiangmin Xu
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-5 (2024)
Abstract The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter reactivated γ-globin express
Externí odkaz:
https://doaj.org/article/0aa26d52d8a142a59376cc32bd6068e3
Autor:
Sheng He, Dongming Li, Shang Yi, Xiuning Huang, Chaofan Zhou, Biyan Chen, Yangjin Zuo, Li Lin, Faqin Chen, Hongwei Wei
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: Thalassemia is one of the most common genetic diseases in southern China. Howerver, population in different regions or different population has their own spectrums of thalassemia. To investigate the prevalence and spectrum features of tha
Externí odkaz:
https://doaj.org/article/d643abf382b74aa99da518a55a45bf5c
Autor:
Cunyou Zhao, Yuhua Ye, Diyu Chen, Xiuqin Bao, Binbin Huang, Yangjin Zuo, Jin Huang, Xinhua Zhang, Xiaoqin Feng, Chunbo Huang, Qianqian Zhang, Jianpei Fang, Yongqiong Liu, Qifa Liu, Peng Xu, Dali Li, Weiwei Yu, Xiangmin Xu, Cunxiang Ju, Yukio Nakamura, Narla Mohandas, Jinquan Lao, Liren Wang, Ryo Kurita, Zhongju Wang, Yafeng Li
Publikováno v:
Am J Hum Genet
The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7094ea6223d67852ea81cac730c2eb
https://doi.org/10.1016/j.ajhg.2021.03.005
https://doi.org/10.1016/j.ajhg.2021.03.005
Autor:
Qi Yang, Yangjin Zuo, Meng Li, Sheng Yi, Yingchi Lu, Qinle Zhang, Limei Huang, Xin Fan, Jingsi Luo, Mengting Li, Shihan Feng, Zailong Qin
Publikováno v:
Blood Coagulation & Fibrinolysis. 31:121-126
Hemophilia B is an X-linked recessive bleeding disorder caused by diverse mutations throughout the F9 gene. The same F9 mutation may result in different degrees of clotting factor deficiency. The aim of this study was to investigate the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa751679d3df3fc5056f17d799878ec2
https://doi.org/10.1097/mbc.0000000000000884
https://doi.org/10.1097/mbc.0000000000000884
Autor:
Hongwei Wei, Sheng He, Shang Yi, Chaofan Zhou, Yangjin Zuo, Faqin Chen, Xiuning Huang, Li Lin, Dongming Li, Biyan Chen
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Frontiers in Pediatrics
Frontiers in Pediatrics
Background: Thalassemia is one of the most common genetic diseases in southern China. Howerver, population in different regions or different population has their own spectrums of thalassemia. To investigate the prevalence and spectrum features of tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db88f37ce2e4091efaa03b59dc36567
https://www.frontiersin.org/articles/10.3389/fped.2021.724196/full
https://www.frontiersin.org/articles/10.3389/fped.2021.724196/full
Publikováno v:
Clinical Epigenetics
Background Reactivation of fetal hemoglobin (HbF, α2γ2) holds a therapeutic target for β-thalassemia and sickle cell disease. Although many HbF regulators have been identified, the methylation patterns in β-globin cluster driving the fetal-to-adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ae936ba20f131d239629e6b5c10ffd
https://pubmed.ncbi.nlm.nih.gov/33272312
https://pubmed.ncbi.nlm.nih.gov/33272312
Autor:
Jingsi Luo, Yueyun Lan, Limei Huang, Mengting Li, Qi Yang, Zailong Qin, Qinle Zhang, Qiuxia Yu, Sheng Yi, Yangjin Zuo
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 31(8)
Hemophilia A is an X-linked hemorrhagic disorder caused by deficiency or dysfunction of the coagulation factor VIII (FVIII), and a great variety of mutations in the factor VIII gene (F8) are identified. We aimed to identify the genetic defects of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f3408527e645c6236acb62670a68a4
https://pubmed.ncbi.nlm.nih.gov/32852327
https://pubmed.ncbi.nlm.nih.gov/32852327
Additional file 1: Phenotypic data of human subjects (Tables S1 and S2) and sequences of primers (Table S3) employed in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858e876d54a1e60005e2e8dab644c923
Autor:
Sheng He, Li Lin, Honghwei Wei, Qiuli Chen, Yangjin Zuo, Biyan Chen, Chenguang Zheng, Xiaoxia Qiu, Qian Qin
Publikováno v:
Hemoglobin. 42:272-275
β-Thalassemia (β-thal) is one of the most common autosomal recessive disorders worldwide. It is caused mainly by point mutations or, more rarely, deletions on the β-globin gene, leading to reduced (β+) or absent (β0) synthesis of the β chains o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c618bfcea9521a71eee27264246b234f
https://doi.org/10.1080/03630269.2018.1531018
https://doi.org/10.1080/03630269.2018.1531018
Autor:
Peng Huang, Biyan Chen, Xiaoxia Qiu, Chenguang Zheng, Xiaoxian Tian, Yangjin Zuo, Sheng He, Li Lin, Jihui Li, Shujie Zhang
Publikováno v:
Hemoglobin. 42:61-64
Hb Bart's hydrops fetalis is the most severe and generally fatal clinical phenotype of α-thalassemia (α-thal), which is due to the deletion of all four functional α-globin genes of hemoglobin (Hb), resulting in no α-globin chain production (- -/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::029751141ad47c2592bb6cde52d3ec6e
https://doi.org/10.1080/03630269.2018.1434198
https://doi.org/10.1080/03630269.2018.1434198