Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Yanghee Woo"'
Autor:
Eric Hee Jun Lee, John P. Murad, Lea Christian, Jackson Gibson, Yukiko Yamaguchi, Cody Cullen, Diana Gumber, Anthony K. Park, Cari Young, Isabel Monroy, Jason Yang, Lawrence A. Stern, Lauren N. Adkins, Gaurav Dhapola, Brenna Gittins, Wen-Chung Chang, Catalina Martinez, Yanghee Woo, Mihaela Cristea, Lorna Rodriguez-Rodriguez, Jun Ishihara, John K. Lee, Stephen J. Forman, Leo D. Wang, Saul J. Priceman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrai
Externí odkaz:
https://doaj.org/article/211ce127e82c40c7b1c8f149a15dcd09
Autor:
Annie Yang, Zhifang Zhang, Shyambabu Chaurasiya, Anthony K. Park, Jianming Lu, Sang-In Kim, Hannah Valencia, Yuman Fong, Yanghee Woo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100734- (2023)
Gastric cancer (GC) peritoneal metastasis (PM) is fatal without effective therapy. We investigated CF17, a new replication-competent chimeric poxvirus, against GC cell lines in vitro and PM in an aggressive GCPM mouse model. We performed viral prolif
Externí odkaz:
https://doaj.org/article/728167b8bf134834a68b049f3bd93a0f
Autor:
Kevin M. Sullivan, Haiqing Li, Annie Yang, Zhifang Zhang, Ruben R. Munoz, Kelly M. Mahuron, Yate-Ching Yuan, Isaac Benjamin Paz, Daniel Von Hoff, Haiyong Han, Yuman Fong, Yanghee Woo
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 4117 (2024)
A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid tumor microenvironment correlates with patient outcomes. We hypothesized that in gastric cancer (GC), macrophages in a polarized immunosuppressive tr
Externí odkaz:
https://doaj.org/article/ad97411e680042f5906b7d7031e45a6e
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Gastric cancer (GC) that metastasizes to the peritoneum is fatal. CF33 and its genetically modified derivatives show cancer selectivity and oncolytic potency against various solid tumors. CF33-hNIS and CF33-hNIS-antiPDL1 have entered phase
Externí odkaz:
https://doaj.org/article/8a66b6a089794249b438e38dcb936b02
Autor:
Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K. Park, Sang-In Kim, Jianming Lu, Tove Olafsen, Susanne G. Warner, Yuman Fong, Yanghee Woo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 331-339 (2022)
Peritoneal carcinomatosis of gastrointestinal malignancies remains fatal. CF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust prec
Externí odkaz:
https://doaj.org/article/b136a546a3ad407fb2d3b3567d1fefc5
Autor:
Shyambabu Chaurasiya, Annie Yang, Zhifang Zhang, Jianming Lu, Hannah Valencia, Sang-In Kim, Yanghee Woo, Suanne G. Warner, Tove Olafsen, Yuqi Zhao, Xiwei Wu, Seymour Fein, Linda Cheng, Maria Cheng, Nicholas Ede, Yuman Fong
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 102-116 (2022)
CF33-hNIS-anti-PD-L1 is an oncolytic chimeric poxvirus encoding two transgenes: human sodium iodide symporter and a single-chain variable fragment against PD-L1. Comprehensive preclinical pharmacology studies encompassing primary and secondary pharma
Externí odkaz:
https://doaj.org/article/970c8e52369d4fbd868c37193c54a126
Autor:
Sang-In Kim, Shyambabu Chaurasiya, Venkatesh Sivanandam, Seonah Kang, Anthony K. Park, Jianming Lu, Annie Yang, Zhifang Zhang, Isabella A. Bagdasarian, Yanghee Woo, Joshua T. Morgan, Zhirong Yin, Yuman Fong, Susanne G. Warner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 864-872 (2022)
Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed. Vitamin D analogs such as calcipotriol (Ca
Externí odkaz:
https://doaj.org/article/b5d91ed5c6a549feb97cb488438d4bd7
Autor:
Zhifang Zhang, Annie Yang, Shyambabu Chaurasiya, Anthony K. Park, Sang-In Kim, Jianming Lu, Hannah Valencia, Yuman Fong, Yanghee Woo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14189 (2023)
We studied the immunotherapeutic potential of CF33-hNIS-antiPDL1 oncolytic virus (OV) against gastric cancer with peritoneal metastasis (GCPM). We collected fresh malignant ascites (MA) or peritoneal washings (PW) during routine paracenteses and diag
Externí odkaz:
https://doaj.org/article/ccb6c7ad833f489791c7f7f0f10ecad2
Autor:
Shyambabu Chaurasiya, Sang-In Kim, Michael O’Leary, Anthony K. Park, Jianming Lu, Seonah Kang, Zhifang Zhang, Annie Yang, Yanghee Woo, Yuman Fong, Susanne G. Warner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 303-310 (2021)
Oncolytic viruses infect, replicate in, and kill cancer cells, leaving normal cells unharmed; they also recruit and activate immune cells against tumor cells. While clinical indications for viroimmunotherapy are growing, barriers to widespread treatm
Externí odkaz:
https://doaj.org/article/793296c2361d438a99b0c7793ab73a81
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 231-238 (2021)
The translation of laboratory science into effective clinical cancer therapy is gaining momentum more rapidly than any other time in history. Understanding cancer cell-surface receptors, cancer cell growth, and cancer metabolic pathways has led to ma
Externí odkaz:
https://doaj.org/article/0bd33052551946cba2a3c9eebd0a6d9e