Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Yangfu, Jiang"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-31 (2024)
Abstract Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental factors. The tumor microenvironment (TME), which involves extracellular matrix, cancer-associated fibroblasts (CAF), tum
Externí odkaz:
https://doaj.org/article/6ce3d67330b24781a9e5066fadf45707
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-27 (2023)
Abstract RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I), melanoma differen
Externí odkaz:
https://doaj.org/article/769a9a401f624fdb98ed64676b21be13
Autor:
Qing Zhang, Lu Wang, Shiqi Wang, Hongxin Cheng, Lin Xu, Gaiqin Pei, Yang Wang, Chenying Fu, Yangfu Jiang, Chengqi He, Quan Wei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-38 (2022)
Abstract Although the treatment of myocardial infarction (MI) has improved considerably, it is still a worldwide disease with high morbidity and high mortality. Whilst there is still a long way to go for discovering ideal treatments, therapeutic stra
Externí odkaz:
https://doaj.org/article/19d7f2c10ef74608bed5ad28154e1696
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Externí odkaz:
https://doaj.org/article/4c6440ef70574de887f6ee8b83152313
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-25 (2021)
Abstract Biomarkers-guided precision therapeutics has revolutionized the clinical development and administration of molecular-targeted anticancer agents. Tailored precision cancer therapy exhibits better response rate compared to unselective treatmen
Externí odkaz:
https://doaj.org/article/02aa5870bab14bc2980f33ab6791c4d4
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1543-1565 (2021)
Early and accurate diagnosis of prostate cancer (PCa) is extremely important, as metastatic PCa remains hard to treat. EWI‐2, a member of the Ig protein subfamily, is known to inhibit PCa cell migration. In this study, we found that EWI‐2 localiz
Externí odkaz:
https://doaj.org/article/6066c6009e9b440cb0889a724830530c
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-12 (2021)
Abstract Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal tr
Externí odkaz:
https://doaj.org/article/9129f35378534a80b22051f158dfcb44
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-17 (2020)
Abstract Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF
Externí odkaz:
https://doaj.org/article/06b4649cf99c46b3b9e47959cf51443a
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2019)
Abstract Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2). In cooperation with raptor, rictor,
Externí odkaz:
https://doaj.org/article/b2f26c6c535c4e95a373b46bd7052153
Publikováno v:
Experimental Hematology & Oncology, Vol 7, Iss 1, Pp 1-11 (2018)
Abstract Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis. Estrogen anta
Externí odkaz:
https://doaj.org/article/8c7e28e0a0b84f949d141cdf5ed90e68