Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yangfan Qi"'
Autor:
Fang Huang, Zhenwei Dai, Jinmiao Yu, Kainan Wang, Chaoqun Chen, Dan Chen, Jinrui Zhang, Jinyao Zhao, Mei Li, Wenjing Zhang, Xiaojie Li, Yangfan Qi, Yang Wang
Publikováno v:
eLife, Vol 13 (2024)
Aberrant alternative splicing is well-known to be closely associated with tumorigenesis of various cancers. However, the intricate mechanisms underlying breast cancer metastasis driven by deregulated splicing events remain largely unexplored. Here, w
Externí odkaz:
https://doaj.org/article/415a2db4498e4b1abe80c7293855a965
Autor:
Yu Sun, Dan Chen, Siwen Sun, Menglin Ren, Liang Zhou, Chaoqun Chen, Jinyao Zhao, Huanhuan Wei, Qingzhi Zhao, Yangfan Qi, Jinrui Zhang, Ge Zhang, Han Liu, Qingkai Yang, Quentin Liu, Yang Wang, Wenjing Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Metastasis is the leading cause for the high mortality of lung cancer, however, effective anti‐metastatic drugs are still limited. Here it is reported that the RNA‐binding protein RBMS1 is positively associated with increased lymph node
Externí odkaz:
https://doaj.org/article/723fd7e34f2340828b252270dad66afd
Autor:
Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-21 (2023)
Abstract Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature senescence to malignant progression rema
Externí odkaz:
https://doaj.org/article/1d7aa7f266ca4e0fb858da4ff60661c8
Autor:
Luning Wang, Xiaohong Zhang, Junxiu Sheng, Lei Chen, Lili Zhi, Qianqian Zheng, Yangfan Qi, Linlin Wang, Jinrui Zhang, Jinyao Zhao, Yang Wang, Shu-Xin Liu, Ming-Zhong Sun, Wenjing Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer development. RNA-binding proteins (RBPs) play important roles in
Externí odkaz:
https://doaj.org/article/42efeb500cc94c99827c0fe30e47cfab
Autor:
Sisi Li, Yangfan Qi, Jiachuan Yu, Yuchao Hao, Lingzhi Xu, Xudong Ding, Minghui Zhang, Jingshu Geng
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17386- (2023)
The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a c
Externí odkaz:
https://doaj.org/article/3871445affc4477695edf38f31e431a0
Autor:
SiSi Li, YangFan Qi, JiaChuan Yu, YuChao Hao, Bin He, MengJuan Zhang, ZhenWei Dai, TongHui Jiang, SuYi Li, Fang Huang, Ning Chen, Jing Wang, MengYing Yang, DaPeng Liang, Fan An, JinYao Zhao, WenJun Fan, YuJia Pan, ZiQian Deng, YuanYuan Luo, Tao Guo, Fei Peng, ZhiJie Hou, ChunLi Wang, FeiMeng Zheng, LingZhi Xu, Jie Xu, QingPing Wen, BiLian Jin, Yang Wang, Quentin Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical activation of nuclear AURKA promo
Externí odkaz:
https://doaj.org/article/f51cec2a13fb480aa35e26ccc9c97976
Autor:
Lu Bai, Siwen Sun, Wenmei Su, Chaoqun Chen, Yuesheng Lv, Jinrui Zhang, Jinyao Zhao, Man Li, Yangfan Qi, Wenjing Zhang, Yang Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hepatocellular carcinoma (HCC) is one of the most common primary cancers with limited therapeutic options. Melatonin, a neuroendocrine hormone produced primarily by the pineal gland, demonstrates an anti-cancer effect on a myriad of cancers including
Externí odkaz:
https://doaj.org/article/d51317a0daff4486bfab5508b3a261d9
Autor:
Yuesheng Lv, Wenjing Zhang, Jinyao Zhao, Bing Sun, Yangfan Qi, Haoyu Ji, Chaoqun Chen, Jinrui Zhang, Junxiu Sheng, Taishu Wang, Daniel Dominguez, Han Liu, Quentin Liu, Songshu Meng, Xiaoling Li, Yang Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive. Here we systematically identify the splicing factor SRSF1 as an autophagy su
Externí odkaz:
https://doaj.org/article/20f514dc99d447b7b6109b14306ed7f6
Autor:
Junxiu Sheng, Qingzhi Zhao, Jinyao Zhao, Wenjing Zhang, Yu Sun, Pan Qin, Yuesheng Lv, Lu Bai, Quan Yang, Lei Chen, Yangfan Qi, Ge Zhang, Lin Zhang, Chundong Gu, Xiaoqin Deng, Han Liu, Songshu Meng, Hong Gu, Quentin Liu, Judy M. Coulson, Xiaoling Li, Bing Sun, Yang Wang
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 113-126 (2018)
Background: Radioresistance is the major cause of cancer treatment failure. Additionally, splicing dysregulation plays critical roles in tumorigenesis. However, the involvement of alternative splicing in resistance of cancer cells to radiotherapy rem
Externí odkaz:
https://doaj.org/article/39f754e42fa4466ebce5a89733468611
Autor:
Yangfan Qi, Jing Yu, Wei Han, Xiaojuan Fan, Haili Qian, Huanhuan Wei, Yi-hsuan S. Tsai, Jinyao Zhao, Wenjing Zhang, Quentin Liu, Songshu Meng, Yang Wang, Zefeng Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEA
Externí odkaz:
https://doaj.org/article/f8a4ec7f1fc64a198fd124141bb70228