Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Yangbo, Feng"'
Autor:
Anna M. Jermakowicz, Matthew J. Rybin, Robert K. Suter, Jann N. Sarkaria, Zane Zeier, Yangbo Feng, Nagi G. Ayad
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Bromodomain and extraterminal domain (BET) proteins have emerged as therapeutic targets in multiple cancers, including the most common primary adult brain tumor glioblastoma (GBM). Although several BET inhibitors have entered clinical trials
Externí odkaz:
https://doaj.org/article/42bc0a0c7a934a7485fd2a2ac6e81440
Autor:
Yanlu Xiong, Yangbo Feng, Jinbo Zhao, Jie Lei, Tianyun Qiao, Yongsheng Zhou, Qiang Lu, Tao Jiang, Lintao Jia, Yong Han
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-13 (2021)
Abstract Transcription factor AP-2α (TFAP2A) was previously regarded as a critical regulator during embryonic development, and its mediation in carcinogenesis has received intensive attention recently. However, its role in lung adenocarcinoma (LUAD)
Externí odkaz:
https://doaj.org/article/342891e44ddc43378e05b51613a04283
Autor:
Tulasigeri M. Totiger, Anirban Ghoshal, Jenna Zabroski, Anya Sondhi, Saanvi Bucha, Jacob Jahn, Yangbo Feng, Justin Taylor
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 641 (2023)
Therapeutic developments targeting acute myeloid leukemia (AML) have been in the pipeline for five decades and have recently resulted in the approval of multiple targeted therapies. However, there remains an unmet need for molecular treatments that c
Externí odkaz:
https://doaj.org/article/464513d88a5c4fde8a27b433577b6a0f
Autor:
Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han, Tao Jiang
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Lung adenocarcinoma (LUAD) remains a crucial factor endangering human health. Gene-based clinical predictions could be of great help for cancer intervention strategies. Here, we tried to build a gene-based survival score (SS) for
Externí odkaz:
https://doaj.org/article/ba2cfa11f65c40e2a6e3bb373dba4e8c
Publikováno v:
IET Image Processing, Vol 14, Iss 11, Pp 2495-2502 (2020)
Kernel‐based extreme learning machine (KELM) solves the problem of random initialisation of extreme learning machine (ELM), and it has a faster learning speed and higher learning accuracy. However, when it comes to a scenario in which the dimension
Externí odkaz:
https://doaj.org/article/7cb3686f681a408ca04cc33cbd562a30
Publikováno v:
IEEE Transactions on Multimedia. :1-16
Autor:
Tianyun Qiao, Yanlu Xiong, Yangbo Feng, Wenwen Guo, Yongsheng Zhou, Jinbo Zhao, Tao Jiang, Changhong Shi, Yong Han
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients, partly because of the lack of sufficient immune cells in the tumor. It is reported that targeted lactate dehydrogenase (LDH) to re
Externí odkaz:
https://doaj.org/article/27738725f5db451e9bbac647d9284625
Autor:
Tianyun, Qiao, Jinbo, Zhao, Xiangbing, Xin, Yanlu, Xiong, Wenwen, Guo, Fancheng, Meng, Hui, Li, Yangbo, Feng, Hui, Xu, Changhong, Shi, Yong, Han
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1169-1181
Antibodies targeting the programmed cell death protein 1/programmed cell death ligand-1 (PD-1/PD-L1) pathway have dramatically changed the treatment landscape of advanced non-small cell lung cancer (NSCLC). However, combination approaches are require
Autor:
Sacnicte Ramirez-Rios, Sophie Michallet, Leticia Peris, Caroline Barette, Clotilde Rabat, Yangbo Feng, Marie-Odile Fauvarque, Annie Andrieux, Karin Sadoul, Laurence Lafanechère
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays sin
Externí odkaz:
https://doaj.org/article/adc39229977a4d7ebef42931cfe2c180
Publikováno v:
ACS Med Chem Lett
[Image: see text] An indazole/aza-indazole scaffold was developed as a novel chemotype for JNK3 inhibition. Extensive structure activity relationship (SAR) studies utilizing various in vitro and in vivo assays led to potent and highly selective JNK3