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Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions

Autor: Zun-Shu Du, Wen-Qi Han, Yun-Jiao Wang, Yang-Hui Bi, Ying Jiang, Ruo-Fei Li, Xue-Jiang Wang

Publikováno v: World Journal of Gastroenterology

Background Study shows that signal transducer and activator of transcription 3 (STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cce95f80c25e77f6c0cb7ea54cd64e
http://europepmc.org/articles/PMC6487376

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[Dynamic changes of TGF-α and TGF-β1 in rats with liver cirrhosis induced by multiple pathogenic factors]

Autor: Xiao-xia, Tian, Hui-ying, Zhang, Li-min, Wang, Xu-jiong, Li, Yan, Liu, Li-li, Zhang, Yang-hui, Bi

Publikováno v: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 32(1)

To explore the dynamic changes of transforming growth factor-α (TGF-α) and transforming growth factor-β1 (TGF-β1) of liver cirrhosis induced by multiple pathogenic factors in rats.Animals in the cirrhosis group were fed a mixture of maize flour,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10ba7fb16930a114a49ee0f7a653d4f8
https://pubmed.ncbi.nlm.nih.gov/27255046

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Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

Autor: Yunxia Chen, Xiaoxia Tian, Xiaojing Zhang, Xujiong Li, Buwu Fang, Lina Lai, Yang-hui Bi, Xiaoliang Song, Jingwen Lei

Publikováno v: European journal of pharmacology. 765

The current study was performed in order to explore the effect of artesunate (Art) on experimental hepatic fibrosis and the potential mechanism involved. Art, a water-soluble hemisuccinate derivative of artemisinin extracted from the Chinese herb Art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85771fe302afc6c1625d2717ff6967c
https://pubmed.ncbi.nlm.nih.gov/26318197

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Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis

Autor: Li Meng, Li Na Lai, Yi Min Fan, Cheng Ji, Yang Hui Bi, Yun Xia Chen, Xiao Xia Tian, Limin Wang, Hui Ying Zhang, De Wu Han, Zhong Fu Zhao, Xu Jiong Li

Publikováno v: World Journal of Gastroenterology. 22:2949

To evaluate the effect of artesunate (AS) supplementation on bacterial translocation (BT) and gut microbiota in a rat model of liver cirrhosis.Fifty-four male Sprague-Dawley rats were randomly divided into a normal control group (N), a liver cirrhosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1317cad46e1a820d9d075e7f1ffdee44
https://doi.org/10.3748/wjg.v22.i10.2949

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