Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yang-bo Yue"'
Publikováno v:
Human Gene Therapy. 21:728-738
The adeno-associated virus (AAV) p5 promoter controls expression of Rep68 and Rep78, which are responsible for specific integration of the viral genome into the AAVS1 site of the human genome. The p5 promoter contains a Rep-binding element (RBE) sequ
Autor:
J Z Chen, Yang-bo Yue, Z X Xu, William Jia, Jianqi Zhang, Z C Ruan, D M Feng, Q J Wang, Ling Tian, Z H Li, Jinglun Xue
Publikováno v:
Gene Therapy. 16:589-595
We earlier reported that, a 16 bp Rep-binding element (RBE) was sufficient for mediating Rep-dependent integration into AAVS1 in vitro. We explored here the potential use of this RBE in site-specific genome integration at the AAVS1 site in vivo using
Publikováno v:
Journal of Molecular Biology. 358:38-45
Adeno-associated virus (AAV) is a non-pathogenic virus and the only known eukaryotic virus capable of targeting human chromosome 19 for integration at a well-characterized AAVS1 site. Its site-specific integration is mediated by Rep68 and Rep78, vira
Publikováno v:
Human Gene Therapy; Jun2010, Vol. 21 Issue 6, p728-738, 11p