Zobrazeno 1 - 10
of 633
pro vyhledávání: '"Yang-Xin Fu"'
Autor:
Hang Zhou, Wenjun Wang, Hairong Xu, Yong Liang, Jiyu Ding, Mengjie Lv, Boyang Ren, Hua Peng, Yang-Xin Fu, Mingzhao Zhu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Type I interferons have been well recognized for their roles in various types of immune cells during tumor immunotherapy. However, their direct effects on tumor cells are less understood. Oxidative phosphorylation is typically latent in tumo
Externí odkaz:
https://doaj.org/article/f9d93d1fc5c24049a61d4663bd676895
Autor:
Zhuangzhi Zou, Jiao Shen, Diyuan Xue, Hongjia Li, Longxin Xu, Weian Cao, Wenyan Wang, Yang-Xin Fu, Hua Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Immune checkpoint blockade (ICB) therapies function by alleviating immunosuppression on tumor-infiltrating lymphocytes (TILs) but are often insufficient to fully reactivate these dysfunctional TILs. Although interleukin 12 (IL-12) has been u
Externí odkaz:
https://doaj.org/article/db2a561e052442479026c904385209a7
Autor:
Soumya Tumbath, Lingxiang Jiang, Xiaoguang Li, Taolan Zhang, Kashif Rafiq Zahid, Ye Zhao, Hao Zhou, Zhijun Yin, Tao Lu, Shu Jiang, Yaomin Chen, Xiang Chen, Yang-Xin Fu, Xiumei Huang
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in most solid cancers, emerging as a promising target for tumor-selective killing. β-Lapachone (β-Lap), an NQO1 bioactivatable drug, exhibits significant antitumor effects on NQO1-positive ca
Externí odkaz:
https://doaj.org/article/949b1bfe9fef4f57be1db5d9a66f7789
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate broadness and functional non-specificity have limited their role in therapeutical success. Functioning as HSP70’s cochaperones, HSP40s determine the
Externí odkaz:
https://doaj.org/article/8a73364ebaba4934b362bd4f292ffff0
Publikováno v:
Vaccines, Vol 12, Iss 5, p 477 (2024)
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), remains a formidable global health challenge, affecting a substantial portion of the world’s population. The current tuberculosis vaccine, bacille Calmette–Guérin (BCG), offer
Externí odkaz:
https://doaj.org/article/b8ae8e9d206546f3af6c107b374364bd
Autor:
Xue Wang, Longchao Liu, Tao Yue, Zhichen Sun, Joonbeom Bae, Kuo-Fu Tseng, Anli Zhang, Jian Qiao, Yang-Xin Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/d11880fa2e3a43bf991ecad4f0c245c7
Autor:
Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D. Sumer, Bo Li, Yang-Xin Fu, Jinming Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Lactic acid from glycolytic metabolism of cancer cells has been associated with immune suppressive functions. Here authors show that lactate, when depart from the acidic protons, inhibits histone deacetylases in CD8 + T cells, which turns them into p
Externí odkaz:
https://doaj.org/article/f046c8ae08fc4d8a94ca232b1d378b19
Autor:
Fanlin Li, Huihui Zhang, Wanting Wang, Puyuan Yang, Yue Huang, Junshi Zhang, Yaping Yan, Yuan Wang, Xizhong Ding, Jie Liang, Xinyue Qi, Min Li, Ping Han, Xiaoqing Zhang, Xin Wang, Jiang Cao, Yang-Xin Fu, Xuanming Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific
Externí odkaz:
https://doaj.org/article/02c488a10011477f8b02989ecac19cbe
Autor:
Yifan Lin, Jing Sun, Xuezhi Cao, Xiuye Wang, Xi Chen, Hairong Xu, Jincun Zhao, Yang-Xin Fu, Hua Peng
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/87378d8640674b53b795d0ebebb8919a
Autor:
Shuo Song, Bing Zhou, Lin Cheng, Weilong Liu, Qing Fan, Xiangyang Ge, Hua Peng, Yang-Xin Fu, Bin Ju, Zheng Zhang
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-5 (2022)
Abstract The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we se
Externí odkaz:
https://doaj.org/article/1be5eeea9bc249f59f66bb66f7b19663