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Akademický článek

Introducing carbon assimilation in yeasts using photosynthetic directed endosymbiosis

Autor: Yang-le Gao, Jason E. Cournoyer, Bidhan C. De, Catherine L. Wallace, Alexander V. Ulanov, Michael R. La Frano, Angad P. Mehta

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Conversion of heterotrophic organisms into partially or completely autotrophic organisms is primarily accomplished by extensive metabolic engineering and laboratory evolution efforts that channel CO2 into central carbon metabolism. Here, we

Externí odkaz: https://doaj.org/article/07c95328604d440c834665bbfd930c50

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Akademický článek

Engineering artificial photosynthetic life-forms through endosymbiosis

Autor: Jason E. Cournoyer, Sarah D. Altman, Yang-le Gao, Catherine L. Wallace, Dianwen Zhang, Guo-Hsuen Lo, Noah T. Haskin, Angad P. Mehta

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

The endosymbiotic theory posits that chloroplasts in eukaryotes arise from bacterial endosymbionts. Here, the authors engineer the yeast/cyanobacteria chimeras and show that the engineered cyanobacteria perform chloroplast-like functions to support t

Externí odkaz: https://doaj.org/article/11598293e32440e2b2f632b0c479fd65

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Akademický článek

Discovery and biosynthesis of macrophasetins from the plant pathogen fungus Macrophomina phaseolina

Autor: Cui Yu, Lin Chen, Yang Le Gao, Jia Liu, Pei Lin Li, Ming Liang Zhang, Qin Li, Huai Dong Zhang, Man Cheng Tang, Li Li

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

3-Decalinoyltetramic acids (DTAs) are a class of natural products with chemical diversity and potent bioactivities. In fungal species there is a general biosynthetic route to synthesize this type of compounds, which usually features a polyketide synt

Externí odkaz: https://doaj.org/article/7ec8dc0a4898481b8b363d46ef8b66f2

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Isolation and characterization of a new cytotoxic polyketide–amino acid hybrid from Thermothelomyces thermophilus ATCC 42464

Autor: Huai-Dong Zhang, Xue Wang, Jianzhong Huang, Yang-Le Gao, Li Li, Ming-Liang Zhang

Publikováno v: Natural Product Research. 35:1792-1798

Fungi are a rich source of novel anticancer compounds. Bioassay-guided isolation has led to the isolation of four polyketide-amino acid hybrid compounds with trans-fused decalin system from the fungus Thermothelomyces thermophilus ATCC 42464 (=Myceli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74211365cbabad5de42ffae1dae64f8f
https://doi.org/10.1080/14786419.2019.1641810

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Heterologous expression of a natural product biosynthetic gene cluster from Cordyceps militaris

Autor: Yang-Le Gao, Li Li, Cui Yu

Publikováno v: The Journal of antibiotics. 75(1)

Cordyceps is a genus of ascomycete fungi widely used in old Chinese medicine, and many investigations have focus on uncovering their biological activities. Until now, only a few compounds have been identified from Cordyceps, mainly due to their poor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f713f80b779be08eea5a63397b0a65c0
https://pubmed.ncbi.nlm.nih.gov/34548637

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Genome mining and biosynthesis of the Acyl-CoA:cholesterol acyltransferase inhibitor beauveriolide I and III in Cordyceps militaris

Autor: Jianzhong Huang, Yang-Le Gao, Ming-Liang Zhang, Li Li, Xue Wang, Huai-Dong Zhang

Publikováno v: Journal of biotechnology. 309

Ascomycete fungi Cordyceps are widely used in traditional Chinese medicine, and numerous investigations have been carried out to uncover their biological activities. However, primary researches on the physiological effects of Cordyceps were committed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b237a0efba268b3252579bbf9bfc73d5
https://pubmed.ncbi.nlm.nih.gov/31926180

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Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from

Autor: Yang-Le, Gao, Ming-Liang, Zhang, Xue, Wang, Huai-Dong, Zhang, Jian-Zhong, Huang, Li, Li

Publikováno v: Natural product research. 35(11)

Fungi are a rich source of novel anticancer compounds. Bioassay-guided isolation has led to the isolation of four polyketide-amino acid hybrid compounds with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2274306687620e20b8ace807e4d8736e
https://pubmed.ncbi.nlm.nih.gov/31309856

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