Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Yang W, Shao"'
Rechallenge of immune checkpoint inhibitors in a case with adverse events inducing myasthenia gravis
Autor:
Jun Li, Wei Wang, Wei Zhang, Yang W Shao, Lu Shen, Liang Chen, Wen Gao, Jiali Xu, Jiani C Yin, Renhua Guo, Qianghu Wang, Lingxiang Wu, Shidai Jin, Xinyin Liu, Qixing Gong, Chunxiao Sun, Zidun Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
The mechanism(s) of immune checkpoint inhibitor (ICI)-induced myasthenia gravis (MG), an immune-related adverse event (irAE) that is fatal and limits subsequent ICI use, remain unexplored. Here, through comparative genomic analysis, we identified a p
Externí odkaz:
https://doaj.org/article/d30424b3fa87428b938f8353ad68fd49
Autor:
Junliang Lu, Ruoying Yu, Rui Liu, Xiaolong Liang, Jian Sun, Hui Zhang, Huanwen Wu, Zhiwen Zhang, Yang W. Shao, Junchao Guo, Zhiyong Liang
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 933-943 (2021)
Abstract Objectives Pancreatic cancer (PC) is one of the most lethal malignancies with an increasing death rate over the years. We performed targeted sequencing and survival analyses on 90 Chinese pancreatic cancer patients, hoping to identify genomi
Externí odkaz:
https://doaj.org/article/9338d627dcd442749826716633feb539
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1695-1704 (2020)
EGFR exon 20 insertions (EGFR e20ins) account for up to 10% of EGFR mutations in lung cancer; however, tumors with EGFR e20ins had poor response rates to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib, erlotinib, afatinib, and osimertinib
Externí odkaz:
https://doaj.org/article/d3f49a3aaaac4b6cae4c5f99453f8767
Autor:
Yun Fan, Jinrong Qiu, Ruoying Yu, Ran Cao, Xiaoxi Chen, Qiuxiang Ou, Xue Wu, Yang W. Shao, Misako Nagasaka, Jiexia Zhang, Sai‐Hong Ignatius Ou
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1731-1739 (2020)
Transmembrane domain (TMD) mutations of ERBB2 have previously been reported in lung cancer patients in addition to well‐studied kinase domain (KD) mutations, which may stabilize ERBB2 heterodimerization with other EGFR family members and favor a ki
Externí odkaz:
https://doaj.org/article/1a614c77b487431b89854c5a9b3a87c4
Autor:
Juntang Guo, Kefeng Ma, Hua Bao, Xiangyuan Ma, Yang Xu, Xue Wu, Yang W. Shao, Mei Jiang, Jin Huang
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA and improve its usage in early cancer diagnosis and treatment
Externí odkaz:
https://doaj.org/article/43face82329d4291a99515a72091ffeb
Publikováno v:
Cancer Medicine, Vol 9, Iss 5, Pp 1628-1637 (2020)
Abstract Background Definitive chemoradiation therapy (dCRT) is the standard treatment for patients with nonsurgical esophageal squamous cell carcinoma (ESCC), yet patients have demonstrated great variations in their responses to dCRT and inevitably
Externí odkaz:
https://doaj.org/article/82f575617bb74847a7df75ef503fce94
Autor:
Wenfeng Fang, Yuxiang Ma, Jiani C. Yin, Huaqiang Zhou, Fufeng Wang, Hua Bao, Ao Wang, Xue Wu, Shaodong Hong, Yunpeng Yang, Yan Huang, Hongyun Zhao, Yang W. Shao, Li Zhang
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 1, Pp 331-336 (2020)
Externí odkaz:
https://doaj.org/article/08a5003c4b0d4330906609ca153de592
Autor:
Yongsheng Wang, Feng Jiang, Ruixue Xia, Ming Li, Chengyun Yao, Yan Li, Hui Li, Qi Zhao, Mingke Shi, Yanzhe Yu, Yang W. Shao, Guoren Zhou, Hongping Xia, Liyun Miao, Hourong Cai
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
We reported unique molecular features of cerebrospinal fluid (CSF) of nonsmall cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM), suggesting establishing CSF as a better liquid biopsy in clinical practices. We performed next-gener
Externí odkaz:
https://doaj.org/article/f60f9904134948eea2de074e2aa4cea9
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-5 (2019)
Abstract Background Pulmonary sarcomatoid carcinoma (SC) consists of both carcinomatous and sarcomatous tumors with high degree of malignancy, rapid progression, and poor prognosis. However, little is known regarding how pulmonary SC develops and pro
Externí odkaz:
https://doaj.org/article/e818c78daa7748a6bb9e35d4321387f3
Autor:
Lingye Qian, Yijun Shi, Fangqiang Li, Yufei Wang, Miao Ma, Yanfang Zhang, Yang W. Shao, Guanghui Zheng, Guojun Zhang
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Metagenomic next-generation sequencing (mNGS) has become a widely used technology that can accurately detect individual pathogens. This prospective study was performed between February 2019 and September 2019 in one of the largest clinical neurosurge
Externí odkaz:
https://doaj.org/article/25ce8705837f4e0c96635ff5754cd7b9