Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Yang K Xiang"'
Autor:
Ao Shen, Dana Chen, Manpreet Kaur, Peter Bartels, Bing Xu, Qian Shi, Joseph M Martinez, Kwun-nok Mimi Man, Madeline Nieves-Cintron, Johannes W Hell, Manuel F Navedo, Xi-Yong Yu, Yang K Xiang
Publikováno v:
eLife, Vol 8 (2019)
G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alpreno
Externí odkaz:
https://doaj.org/article/266d8af6235543e79ba88e11968e5dbc
Autor:
Joo Lee, Caitlin A Taylor, Kristopher M Barnes, Ao Shen, Emerson V Stewart, Allison Chen, Yang K Xiang, Zhirong Bao, Kang Shen
Publikováno v:
eLife, Vol 8 (2019)
Cellular differentiation requires both activation of target cell transcriptional programs and repression of non-target cell programs. The Myt1 family of zinc finger transcription factors contributes to fibroblast to neuron reprogramming in vitro. Her
Externí odkaz:
https://doaj.org/article/4f9ef3ae95d8453cbf9c3ee0c9a0936f
Autor:
Maria Paz Prada, Arsalan U Syed, Olivia R Buonarati, Gopireddy R Reddy, Matthew A Nystoriak, Debapriya Ghosh, Sergi Simó, Daisuke Sato, Kent C Sasse, Sean M Ward, Luis F Santana, Yang K Xiang, Johannes W Hell, Madeline Nieves-Cintrón, Manuel F Navedo
Publikováno v:
eLife, Vol 8 (2019)
Elevated glucose increases vascular reactivity by promoting L-type CaV1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a Gs-coupled P2Y receptor is an upstream activator of PKA med
Externí odkaz:
https://doaj.org/article/834ddbe5b2af4b2d9cbfe39b3182cbe7
Publikováno v:
eLife, Vol 5 (2016)
Ligand receptor interactions instruct axon guidance during development. How dendrites are guided to specific targets is less understood. The C. elegans PVD sensory neuron innervates muscle-skin interface with its elaborate dendritic branches. Here, w
Externí odkaz:
https://doaj.org/article/0587a01b189a4a669b5bc5d2ec5ba165
Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150125 (2016)
We describe three recombinant engineered antibodies against three recombinant epitope tags, constructed with divalent binding arms to recognize divalent epitopes and so achieve high affinity and specificity. In two versions, an epitope is inserted in
Externí odkaz:
https://doaj.org/article/a25f87d79c794d2ea4a40de0730b7ba8
Autor:
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart. Methods and
Externí odkaz:
https://doaj.org/article/4b237769ac1048998f02d9e4c2aae20f
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63379 (2013)
Previous studies have determined that the type-1 PDZ sequence at the extreme carboxy-terminus of the ß1-adrenergic receptor (ß1-AR) binds SAP97 and AKAP79 to organize a scaffold involved in trafficking of the ß1-AR. In this study we focused on cha
Externí odkaz:
https://doaj.org/article/9bb5220e3f234ac1af80491637a33972
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42658 (2012)
β(2) adrenergic receptor (β(2)AR) is a prototypical G-protein coupled receptor that stimulates the classic cAMP-protein kinase A (PKA) signaling pathway. Recent studies indicate that the cAMP-PKA activities are spatiotemporally regulated in part du
Externí odkaz:
https://doaj.org/article/889369b0d4ea409091f05589da0045a1
Publikováno v:
Cells, Vol 12, Iss 12, p 1667 (2023)
Pathological cardiac hypertrophy is one of the notable causes of heart failure. Circular RNAs (circRNAs) have been studied in association with cardiac hypertrophy; however, the mechanisms by which circRNAs regulate cardiac hypertrophy remain unclear.
Externí odkaz:
https://doaj.org/article/47f6d7bebac443ee87dcc2deba7a80b3
Publikováno v:
Cells; Volume 12; Issue 12; Pages: 1667
Pathological cardiac hypertrophy is one of the notable causes of heart failure. Circular RNAs (circRNAs) have been studied in association with cardiac hypertrophy; however, the mechanisms by which circRNAs regulate cardiac hypertrophy remain unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ca7a1bd9ab923fd3cf04fa3c639beaba