Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Yang K Xiang"'
Autor:
Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Background Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (β1AR) in heart failure. We aim to explore the differential downregulation subcellular pools of β1AR signaling in the heart. Methods and
Externí odkaz:
https://doaj.org/article/4b237769ac1048998f02d9e4c2aae20f
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-11 (2022)
Highlights Design a FRET-based biosensor to monitor PKA dynamics at the RyR2 nanodomains in myocytes Stimulation of β1AR promotes PKA activity at both RyR2 and SERCA2a nanodomains whereas stimulation of β2AR does not Inhibition of PDE3 and PDE4 enh
Externí odkaz:
https://doaj.org/article/7111e54852a64d15b0c529b3d9cf71da
Publikováno v:
Cells, Vol 12, Iss 12, p 1667 (2023)
Pathological cardiac hypertrophy is one of the notable causes of heart failure. Circular RNAs (circRNAs) have been studied in association with cardiac hypertrophy; however, the mechanisms by which circRNAs regulate cardiac hypertrophy remain unclear.
Externí odkaz:
https://doaj.org/article/47f6d7bebac443ee87dcc2deba7a80b3
Autor:
Maria Paz Prada, Arsalan U. Syed, Gopireddy R. Reddy, Miguel Martín-Aragón Baudel, Víctor A. Flores-Tamez, Kent C. Sasse, Sean M. Ward, Padmini Sirish, Nipavan Chiamvimonvat, Peter Bartels, Eamonn J. Dickson, Johannes W. Hell, John D. Scott, Luis F. Santana, Yang K. Xiang, Manuel F. Navedo, Madeline Nieves-Cintrón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Molecular mechanisms by which glucose modulates L-type Ca2+ channel activity and vascular reactivity are unclear. Here the authors report a nanocomplex orchestrated by AKAP5 that facilitates local purinergic stimulation of L-type Ca2+ channels and va
Externí odkaz:
https://doaj.org/article/16c1bd62635d42608c4af12cd7cb45a7
Autor:
Paipai Guo, Yu Tai, Manman Wang, Hanfei Sun, Lingling Zhang, Wei Wei, Yang K. Xiang, Qingtong Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
G protein-coupled receptors (GPCRs), as the largest family of receptors in the human body, are involved in the pathological mechanisms of many diseases. Heterotrimeric G proteins represent the main molecular switch and receive cell surface signals fr
Externí odkaz:
https://doaj.org/article/7135ec115b8a4a3eb8488ef34daae780
Autor:
Gopireddy R. Reddy, Lu Ren, Phung N. Thai, Jessica L. Caldwell, Manuela Zaccolo, Julie Bossuyt, Crystal M. Ripplinger, Yang K. Xiang, Madeline Nieves-Cintrón, Nipavan Chiamvimonvat, Manuel F. Navedo
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103693- (2022)
Summary: Sinoatrial node (SAN) cells are the pacemakers of the heart. This study describes a method for culturing and infection of adult mouse SAN cells with FRET-based biosensors that can be exploited to examine signaling events. SAN cells cultured
Externí odkaz:
https://doaj.org/article/a4901bdc385443a6b47fa18fb6c488d0
Autor:
Ao Shen, Madeline Nieves-Cintron, Yawen Deng, Qian Shi, Dhrubajyoti Chowdhury, Jinyi Qi, Johannes W. Hell, Manuel F. Navedo, Yang K. Xiang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
β2-adrenergic receptor (β2AR) can be phosphorylated by G protein receptor kinases and second messenger-dependent kinases. Here, the authors demonstrate that these phosphorylation events are specific to functionally distinct and spatially segregated
Externí odkaz:
https://doaj.org/article/7b42cd1c08694ec3afc892e537f6001c
Autor:
Tommaso Patriarchi, Ao Shen, Wei He, Mo Baikoghli, R. Holland Cheng, Yang K. Xiang, Matthew A. Coleman, Lin Tian
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Modification of membrane receptor makeup is one of the most efficient ways to control input-output signals but is usually achieved by expressing DNA or RNA-encoded proteins or by using other genome-editing methods, which can be technically c
Externí odkaz:
https://doaj.org/article/d4115b454b4245c79e61e876075b3332
Publikováno v:
Cells; Volume 12; Issue 12; Pages: 1667
Pathological cardiac hypertrophy is one of the notable causes of heart failure. Circular RNAs (circRNAs) have been studied in association with cardiac hypertrophy; however, the mechanisms by which circRNAs regulate cardiac hypertrophy remain unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ca7a1bd9ab923fd3cf04fa3c639beaba
Autor:
Bingqing Deng, Yu Zhang, Chaoqun Zhu, Ying Wang, Eric Weatherford, Bing Xu, Xianhui Liu, Simon J. Conway, E. Dale Abel, Yang K. Xiang
Publikováno v:
Circulation Research. 132:106-108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca9622cbb1846d86b69aaed11861fde8
https://doi.org/10.1161/circresaha.122.321816
https://doi.org/10.1161/circresaha.122.321816