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Tumor Angiogenesis Therapy Using Targeted Delivery of Paclitaxel to the Vasculature of Breast Cancer Metastases

Autor: Yang J. Lu, John M. Ndungu, Terry W. Moore, Daniel J. Brat, Aiming Sun, Ernest T. Parker, Walter Kisiel, Mamoru Shoji, Bassel F. El-Rayes, Dennis C. Liotta, Lars Christian Petersen, Shijun Zhu, James P. Snyder

Publikováno v: Journal of Drug Delivery
Journal of Drug Delivery, Vol 2014 (2014)

Breast cancer aberrantly expresses tissue factor (TF) in cancer tissues and cancer vascular endothelial cells (VECs). TF plays a central role in cancer angiogenesis, growth, and metastasis and, as such, is a target for therapy and drug delivery. TF i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330700240c2156d8d64979104ee6a6e4
https://doi.org/10.1155/2014/865732

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Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa

Autor: Christopher E. Nichols, James P. Snyder, Jan Pohl, Aiming Sun, Mamoru Shoji, Walter Kisiel, Yang J. Lu, Hyunsuk Shim, Bernard E. McCarey, Dennis C. Liotta, Aaron R. Alizadeh, Ernest T. Parker, Cara Mosley

Publikováno v: Journal of Drug Targeting. 16:185-197

Tissue factor (TF) is aberrantly expressed on tumor vascular endothelial cells (VECs) and on cancer cells in many malignant tumors, but not on normal VECs, making it a promising target for cancer therapy. As a transmembrane receptor for coagulation f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becacc13022ac2ff00bbcc866d08b183
https://doi.org/10.1080/10611860801890093

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Synthesis of EF24−Tripeptide Chloromethyl Ketone: A Novel Curcumin-Related Anticancer Drug Delivery System

Autor: Aiming Sun, James P. Snyder, Dennis C. Liotta, Yang J. Lu, Mamoru Shoji

Publikováno v: Journal of Medicinal Chemistry. 49:3153-3158

The blood coagulation cascade includes a step in which the soluble protein, factor VIIa (fVIIa), complexes with its transmembrane receptor, tissue factor (TF). The fVIIa/TF protein-protein complex is subsequently drawn into the cell by endocytosis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754dfc697825da19d990d5272ff6091a
https://doi.org/10.1021/jm051141k

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Diastereomers of Dibromo-7-epi-10-deacetylcephalomannine: Crowded and Cytotoxic Taxanes Exhibit Halogen Bonds

Autor: Yang J. Lu, Ana A. Alcaraz, Yi Jiang, Hisayoshi Kobayashi, James P. Snyder, Jianmin Chen

Publikováno v: Journal of Medicinal Chemistry. 49:1891-1899

The diastereomers of dibromo-7-epi-10-deacetylcephalomannine (6 and 7) have been isolated and characterized. Cytotoxicity and microtubule assembly assays demonstrate that cephalomannine analogue 6 possesses a potency profile very similar to that of T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c542b59680a7d7b6a7a07e7fe10e29
https://doi.org/10.1021/jm0509243

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EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Autor: Dennis C. Liotta, Aiming Sun, Marike Herold, Jeff Armstrong, James P. Snyder, Jiyang Cai, Yang J. Lu, Dean P. Jones, Mamoru Shoji, Brian Adams

Publikováno v: Anti-Cancer Drugs. 16:263-275

In this study, we show that the novel synthetic curcumin analog, EF24, induces cell cycle arrest and apoptosis by means of a redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. Cell cycle analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab5dfc54d2de6d2c8ce0dda520a5282
https://doi.org/10.1097/00001813-200503000-00005

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Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

Autor: Bassel F. El-Rayes, Jann N. Sarkaria, John M. Ndungu, James P. Snyder, Aiming Sun, Mamoru Shoji, Ernest T. Parker, Shijun Zhu, Yang J. Lu, Terry W. Moore, Dennis C. Liotta, Lars Christian Petersen, Walter Kisiel, Daniel J. Brat

Publikováno v: Journal of drug targeting. 23(3)

We have developed a specific technique for imaging cancer in vivo using Cy5.5-labeled factor VIIa (fVIIa), clotting-deficient FFRck-fVIIa, paclitaxel-FFRck-fVIIa, and anti-tissue factor (TF) antibody. FVIIa is the natural ligand for TF. We took advan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e2c81d1e34739cfca455db5c14be52
https://pubmed.ncbi.nlm.nih.gov/25510254

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Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation

Autor: John M. Ndungu, Aiming Sun, Shijun Zhu, Dong M. Shin, Georgia Z. Chen, James P. Snyder, Xu Wang, Chao Yang, Mamoru Shoji, Yang J. Lu

Publikováno v: Journal of medicinal chemistry. 53(8)

We previously reported a novel drug delivery system, drug-linker-Phe-Phe-Arg-methylketone-(FFR-mk)-factor VIIa (fVIIa). The method utilizes tissue factor (TF), which is aberrantly and abundantly expressed on many cancer cells. The advantage of this d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c328419011564bdb1077d702a3511df
https://pubmed.ncbi.nlm.nih.gov/20302303

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Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

Autor: Haipeng Hu, James P. Snyder, Yang J. Lu, Mamoru Shoji, Aiming Sun, Dennis C. Liotta

Publikováno v: Bioorganicmedicinal chemistry letters. 19(23)

A series of novel curcumin analogs, symmetrical dienones, were previously shown to possess cytotoxic, anti-angiogenic and anti-tumor activities. Analogs 1 (EF24) and 2 (EF31) share the dienone scaffold and serve as Michael acceptors. We propose that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc7a246775741637e952a53c2a73853
https://pubmed.ncbi.nlm.nih.gov/19854644

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Simultaneous costal cartilage-sparing modified Ravitch procedure and latissimus dorsi transfer for chest wall deformity repair in Poland's syndrome

Autor: Anthony W. Kim, Michael W. Dingeldein, Mark J. Holterman, Srdjan A. Ostric, Chia yang J Lu, Michael J. Liptay

Publikováno v: Journal of pediatric surgery. 44(1)

Poland's syndrome is a constellation of rare congenital anomalies that include hypoplasia of breast and underlying subcutaneous tissue, absence of the costosternal portion of the pectoralis major muscle, deformity or absence of ribs, absence of axill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8b9db9f7c755acba14bc80fdf487f8
https://pubmed.ncbi.nlm.nih.gov/19159707

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Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging

Autor: Rodney Greene, Chia Yang J. Lu, John A. Doukas, David A. Fullerton, Noam Belkind, Glenn F. Pierce, Keith A. Horvath

Publikováno v: The Annals of thoracic surgery. 74(2)

Although it has been shown that gene therapy is capable of inducing neovascularization in ischemic myocardium, the functional significance of such therapeutic angiogenesis remains less certain. The purpose of this study was to investigate whether an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4972344dc99254e7aad96ff08943c967
https://pubmed.ncbi.nlm.nih.gov/12173832

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