Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Yang Hsia"'
Autor:
William Sheffler, Erin C Yang, Quinton Dowling, Yang Hsia, Chelsea N Fries, Jenna Stanislaw, Mark D Langowski, Marisa Brandys, Zhe Li, Rebecca Skotheim, Andrew J Borst, Alena Khmelinskaia, Neil P King, David Baker
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1010680 (2023)
Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines. One of the major routes to such materials is rigid body sequence-independent docking of cy
Externí odkaz:
https://doaj.org/article/19afdf7c313d401a9ed335aa3e0d5a14
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assembli
Externí odkaz:
https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
Autor:
YANG HSIA HOUNG, 楊熙宏
93
Watersheds rocks in Tatun volcano group is under volcano function all the year round, ground bottom magma storehouse remaining energy and rainwater form the hot liquid to exchange.insolvable gas to squirt to increase rocks to weathering effec
Watersheds rocks in Tatun volcano group is under volcano function all the year round, ground bottom magma storehouse remaining energy and rainwater form the hot liquid to exchange.insolvable gas to squirt to increase rocks to weathering effec
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/66896785554261112988
Autor:
Sherry Bermeo, Andrew Favor, Ya-Ting Chang, Andrew Norris, Scott E. Boyken, Yang Hsia, Hugh K. Haddox, Chunfu Xu, T. J. Brunette, Vicki H. Wysocki, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature Structural & Molecular Biology. 29:1266-1276
The de novo design of three protein chains that associate to form a heterotrimer (but not any of the possible two-chain heterodimers) and that can drive the assembly of higher-order branching structures is an important challenge for protein design. W
Autor:
Zhe Li, Shunzhi Wang, Una Nattermann, Asim K. Bera, Andrew J. Borst, Matthew J. Bick, Erin C. Yang, William Sheffler, Byeongdu Lee, Soenke Seifert, Hannah Nguyen, Alex Kang, Radhika Dalal, Joshua M. Lubner, Yang Hsia, Hugh Haddox, Alexis Courbet, Quinton Dowling, Marcos Miranda, Andrew Favor, Ali Etemadi, Natasha I. Edman, Wei Yang, Banumathi Sankaran, Babak Negahdari, David Baker
SummaryProtein crystallization plays a central role in structural biology1, with broad impact2in pharmaceutical formulation3, drug delivery4, biosensing5, and biocatalysis6,7. Despite this importance, the process of protein crystallization remains po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c9e49b9bf954ca7ba67cff48a16384
https://doi.org/10.1101/2022.11.18.517014
https://doi.org/10.1101/2022.11.18.517014
Autor:
William Sheffler, Erin C. Yang, Quinton Dowling, Yang Hsia, Chelsea N. Fries, Jenna Stanislaw, Mark Langowski, Marisa Brandys, Alena Khmelinskaia, Neil P. King, David Baker
Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines. One of the major routes to such materials is rigid body sequence-independent docking of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4db86fb74f477adff1c1f635ef344b
https://doi.org/10.1101/2022.10.25.513641
https://doi.org/10.1101/2022.10.25.513641
Autor:
Jing Yang (John) Wang, Alena Khmelinskaia, William Sheffler, Marcos C. Miranda, Aleksandar Antanasijevic, Andrew J. Borst, Susana V. Torres, Chelsea Shu, Yang Hsia, Una Nattermann, Daniel Ellis, Carl Walkey, Maggie Ahlrichs, Sidney Chan, Alex Kang, Hannah Nguyen, Claire Sydeman, Banumathi Sankaran, Mengyu Wu, Asim K. Bera, Lauren Carter, Brooke Fiala, Michael Murphy, David Baker, Andrew B. Ward, Neil P. King
Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c7abbdfb14cb721d89bac11eda22f
https://doi.org/10.1101/2022.08.04.502842
https://doi.org/10.1101/2022.08.04.502842
Autor:
Chih-Jen Lin, Jui-Yang Hsia
Publikováno v:
IEEE Transactions on Neural Networks and Learning Systems. 31:5639-5644
In linear support vector regression (SVR), the regularization and error sensitivity parameters are used to avoid overfitting the training data. A proper selection of parameters is very essential for obtaining a good model, but the search process may
Autor:
William A. Catterall, Qi Xu, Daohua Jiang, Atsuko Uyeda, Jiayi Dou, Tamer M. Gamal El-Din, Tomoaki Matsuura, Yang Hsia, David Baker, Dan Ma, Matthew J. Bick, T. J. Brunette, Justin M. Kollman, Chunfu Xu, Hua Bai, Eric M. Lynch, Po-Ssu Huang, Gabriella Reggiano, Peilong Lu, Scott E. Boyken, Matthew C. Johnson, Xue Y. Pei, Frank DiMaio, Lance Stewart, Ben F. Luisi
Publikováno v:
Nature
Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amph
Autor:
Danny D. Sahtoe, Florian Praetorius, Alexis Courbet, Yang Hsia, Basile I. M. Wicky, Natasha I. Edman, Lauren M. Miller, Bart J. R. Timmermans, Justin Decarreau, Hana M. Morris, Alex Kang, Asim K. Bera, David Baker
Publikováno v:
Science. 375
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association but also be stable and well be