Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Yang Hsia"'
Autor:
William Sheffler, Erin C Yang, Quinton Dowling, Yang Hsia, Chelsea N Fries, Jenna Stanislaw, Mark D Langowski, Marisa Brandys, Zhe Li, Rebecca Skotheim, Andrew J Borst, Alena Khmelinskaia, Neil P King, David Baker
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1010680 (2023)
Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines. One of the major routes to such materials is rigid body sequence-independent docking of cy
Externí odkaz:
https://doaj.org/article/19afdf7c313d401a9ed335aa3e0d5a14
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assembli
Externí odkaz:
https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
Autor:
Sherry Bermeo, Andrew Favor, Ya-Ting Chang, Andrew Norris, Scott E. Boyken, Yang Hsia, Hugh K. Haddox, Chunfu Xu, T. J. Brunette, Vicki H. Wysocki, Gira Bhabha, Damian C. Ekiert, David Baker
Publikováno v:
Nature Structural & Molecular Biology. 29:1266-1276
The de novo design of three protein chains that associate to form a heterotrimer (but not any of the possible two-chain heterodimers) and that can drive the assembly of higher-order branching structures is an important challenge for protein design. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d03da5b839f52c7a70299d616cccb41
https://doi.org/10.1038/s41594-022-00879-4
https://doi.org/10.1038/s41594-022-00879-4
Autor:
Zhe Li, Shunzhi Wang, Una Nattermann, Asim K. Bera, Andrew J. Borst, Matthew J. Bick, Erin C. Yang, William Sheffler, Byeongdu Lee, Soenke Seifert, Hannah Nguyen, Alex Kang, Radhika Dalal, Joshua M. Lubner, Yang Hsia, Hugh Haddox, Alexis Courbet, Quinton Dowling, Marcos Miranda, Andrew Favor, Ali Etemadi, Natasha I. Edman, Wei Yang, Banumathi Sankaran, Babak Negahdari, David Baker
SummaryProtein crystallization plays a central role in structural biology1, with broad impact2in pharmaceutical formulation3, drug delivery4, biosensing5, and biocatalysis6,7. Despite this importance, the process of protein crystallization remains po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c9e49b9bf954ca7ba67cff48a16384
https://doi.org/10.1101/2022.11.18.517014
https://doi.org/10.1101/2022.11.18.517014
Autor:
William Sheffler, Erin C. Yang, Quinton Dowling, Yang Hsia, Chelsea N. Fries, Jenna Stanislaw, Mark Langowski, Marisa Brandys, Alena Khmelinskaia, Neil P. King, David Baker
Computationally designed multi-subunit assemblies have shown considerable promise for a variety of applications, including a new generation of potent vaccines. One of the major routes to such materials is rigid body sequence-independent docking of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4db86fb74f477adff1c1f635ef344b
https://doi.org/10.1101/2022.10.25.513641
https://doi.org/10.1101/2022.10.25.513641
Autor:
Jing Yang (John) Wang, Alena Khmelinskaia, William Sheffler, Marcos C. Miranda, Aleksandar Antanasijevic, Andrew J. Borst, Susana V. Torres, Chelsea Shu, Yang Hsia, Una Nattermann, Daniel Ellis, Carl Walkey, Maggie Ahlrichs, Sidney Chan, Alex Kang, Hannah Nguyen, Claire Sydeman, Banumathi Sankaran, Mengyu Wu, Asim K. Bera, Lauren Carter, Brooke Fiala, Michael Murphy, David Baker, Andrew B. Ward, Neil P. King
Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c7abbdfb14cb721d89bac11eda22f
https://doi.org/10.1101/2022.08.04.502842
https://doi.org/10.1101/2022.08.04.502842
Autor:
Chih-Jen Lin, Jui-Yang Hsia
Publikováno v:
IEEE Transactions on Neural Networks and Learning Systems. 31:5639-5644
In linear support vector regression (SVR), the regularization and error sensitivity parameters are used to avoid overfitting the training data. A proper selection of parameters is very essential for obtaining a good model, but the search process may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fafddd05902da384a2aae41c2966ba7
https://doi.org/10.1109/tnnls.2020.2967637
https://doi.org/10.1109/tnnls.2020.2967637
Autor:
William A. Catterall, Qi Xu, Daohua Jiang, Atsuko Uyeda, Jiayi Dou, Tamer M. Gamal El-Din, Tomoaki Matsuura, Yang Hsia, David Baker, Dan Ma, Matthew J. Bick, T. J. Brunette, Justin M. Kollman, Chunfu Xu, Hua Bai, Eric M. Lynch, Po-Ssu Huang, Gabriella Reggiano, Peilong Lu, Scott E. Boyken, Matthew C. Johnson, Xue Y. Pei, Frank DiMaio, Lance Stewart, Ben F. Luisi
Publikováno v:
Nature
Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b9825492d180b0abadeeb58f81bed8
http://europepmc.org/articles/PMC7483984
http://europepmc.org/articles/PMC7483984
Autor:
Danny D. Sahtoe, Florian Praetorius, Alexis Courbet, Yang Hsia, Basile I. M. Wicky, Natasha I. Edman, Lauren M. Miller, Bart J. R. Timmermans, Justin Decarreau, Hana M. Morris, Alex Kang, Asim K. Bera, David Baker
Publikováno v:
Science. 375
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association but also be stable and well be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7906ff67d195ff1a34a05f7b985ecd2f
https://doi.org/10.1126/science.abj7662
https://doi.org/10.1126/science.abj7662
Autor:
Joel Quispe, David Veesler, Philip Bradley, Scott E. Boyken, David Baker, Una Nattermann, William Sheffler, D. Nagarajan, George Ueda, Alexis Courbet, Young-Jun Park, Justin M. Kollman, J. P. Hansen, Bethel Np, Daniel-Adriano Silva, Adam Moyer, Chunfu Xu, Yang Hsia, Neil P. King
Natural nanomachines like the F1/F0-ATPase contain protein components that undergo rotation relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1980c347129ed6f10ca632fa616b536
https://doi.org/10.1101/2021.11.11.468255
https://doi.org/10.1101/2021.11.11.468255