Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations: Cancer Research

Autor: Fehringer, G., Kraft, P., Pharoah, Paul D. P., Eeles, Rosalind A., Chatterjee, N., Schumacher, Fredrick R., Schildkraut, Joellen M., Lindstrom, S., Brennan, P., Bickeboller, H., Houlston, Richard S., Landi, M.T., Caporaso, N., Risch, A., Al Olama, A. A., Berndt, Sonja I, Giovannucci, E.L., Gronberg, H., Kote-Jarai, Zsofia, Ma, Jun, Muir, K., Stampfer, M. J., Stevens, V.L., Wiklund, Fredrik, Willett, W.C., Goode, Ellen L., Permuth, J. B., Risch, Harvey A., Reid, B. M., Bezieau, S., Brenner, H., Chan, T.A., Chang-Claude, J., Hudson, T.J., Kocarnik, J. K., Newcomb, Polly A., Schoen, R.E., Slattery, M. L., White, E., Adank, M. A., Ahsan, H., Aittomaki, K., Baglietto, L., Blomquist, C., Canzian, F., Czene, K., dos Santos Silva, I., Eliassen, A. H., Figueroa, J.D., Flesch-Janys, D., Fletcher, O., Garcia-Closas, M., Gaudet, M., Johnson, N., Hall, P., Hazra, A., Hein, R., Hofman, A., Hopper, John L., Irwanto, A., Johansson, M., Kaaks, R., Kibriya, M.G., Lichtner, P., Liu, J., Lund, E., Makalic, E., Meindl, A., Muller-Myhsok, B., Muranen, Taru A., Nevanlinna, H., Peeters, Petra H., Peto, J., Prentice, R. L., Rahman, N., Sanchez, Anthony M. J., Schmidt, Daniel F., Schmutzler, Rita K., Southey, Melissa C., Tamimi, R., Travis, R.C., Turnbull, C., Uitterlinden, A. G., Wang, M. -Z., Whittemore, Alice S., Yang, X. H. R., Zheng, W., Buchanan, D. D., Casey, G., Conti, David V., Edlund, Christopher K., Gallinger, S., Haile, R. W., Jenkins, M., Le Marchand, L., Li, L., Lindor, N.M., Schmit, S. L., Thibodeau, S. N., Woods, M. O., Rafnar, T., Gudmundsson, J., Stacey, S.N., Stefansson, K., Sulem, P., Chen, A.Y., Tyrer, Jonathan P, Christiani, David C., Wei, Y., Shen, H. B., Hu, Z. B., Shu, X.O., Shiraishi, K., Takahashi, A., Bosse, Y., Obeidat, M., Nickle, D., Timens, W., Freedman, Matthew L., Li, Y.Q., Seminara, D., Chanock, Stephen J, Gong, J., Peters, U., Gruber, Stephen B., Amos, Christopher I., Sellers, Thomas A., Easton, Douglas F., Hunter, David J., Haiman, Christopher A., Henderson, B.E., Hung, Rayjean J., [Unknown], Ocac, Consortium, Practical, Hereditary Breast Ovarian Canc, Res, Colorectal, Transdisciplinary, African Amer Breast, Canc, African Ancestry Prostate, Canc

Publikováno v: Cancer Research, 76, 5103-5114. American Association for Cancer Research Inc.
Fehringer, G, Kraft, P, Pharoah, P D P, Eeles, R A, Chatterjee, N, Schumacher, F R, Schildkraut, J M, Lindstrom, S, Brennan, P, Bickeboller, H, Houlston, R S, Landi, M T, Caporaso, N, Risch, A, Al Olama, A A, Berndt, S I, Giovannucci, E L, Gronberg, H, Kote-Jarai, Z, Ma, J, Muir, K, Stampfer, M J, Stevens, V L, Wiklund, F, Willett, W C, Goode, E L, Permuth, J B, Risch, H A, Reid, B M, Bezieau, S, Brenner, H, Chan, T A, Chang-Claude, J, Hudson, T J, Kocarnik, J K, Newcomb, P A, Schoen, R E, Slattery, M L, White, E, Adank, M A, Ahsan, H, Aittomaki, K, Baglietto, L, Blomquist, C, Canzian, F, Czene, K, dos Santos Silva, I, Eliassen, A H, Figueroa, J D, Flesch-Janys, D, Fletcher, O, Garcia-Closas, M, Gaudet, M, Johnson, N, Hall, P, Hazra, A, Hein, R, Hofman, A, Hopper, J L, Irwanto, A, Johansson, M, Kaaks, R, Kibriya, M G, Lichtner, P, Liu, J, Lund, E, Makalic, E, Meindl, A, Muller-Myhsok, B, Muranen, T A, Nevanlinna, H, Peeters, P H, Peto, J, Prentice, R L, Rahman, N, Sanchez, A M J, Schmidt, D F, Schmutzler, R K, Southey, M C, Tamimi, R, Travis, R C, Turnbull, C, Uitterlinden, A G, Wang, M-Z, Whittemore, A S, Yang, X H R, Zheng, W, Buchanan, D D, Casey, G, Conti, D V, Edlund, C K, Gallinger, S, Haile, R W, Jenkins, M, Le Marchand, L, Li, L, Lindor, N M, Schmit, S L, Thibodeau, S N, Woods, M O, Rafnar, T, Gudmundsson, J, Stacey, S N, Stefansson, K, Sulem, P, Chen, A Y, Tyrer, J P, Christiani, D C, Wei, Y, Shen, H B, Hu, Z B, Shu, X O, Shiraishi, K, Takahashi, A, Bosse, Y, Obeidat, M, Nickle, D, Timens, W, Freedman, M L, Li, Y Q, Seminara, D, Chanock, S J, Gong, J, Peters, U, Gruber, S B, Amos, C I, Sellers, T A, Easton, D F, Hunter, D J, Haiman, C A, Henderson, B E, Hung, R J, [Unknown], O, Consortium, P, Hereditary Breast Ovarian Canc, R, Colorectal, T, African Amer Breast, C & African Ancestry Prostate, C 2016, ' Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations : Cancer Research ', Cancer Research, vol. 76, pp. 5103-5114 . https://doi.org/10.1158/0008-5472.can-15-2980

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from

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https://research.vumc.nl/en/publications/740eb848-71bf-48da-b54f-6e9b64527f7d