Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Yanfen Fang"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Histone deacetylase (HDAC) is a kind of protease that modifies histone to regulate gene expression, and is usually abnormally activated in tumors. The approved pan-HDAC inhibitors have demonstrated clinical benefits for patients in some hema
Externí odkaz:
https://doaj.org/article/e398fc592c2e4529b43a29d207d4217d
Autor:
Wenyu MEI, Yanfen FANG, Chao GONG, Peiting MAI, Baojuan SUN, Zhiliang LI, Tao LI, Guangwen SUN
Publikováno v:
Guangdong nongye kexue, Vol 49, Iss 12, Pp 20-33 (2022)
【Objective】The study was carried out to identify the SmTCP gene and analyze the members of SmTCP transcription factor family in eggplant. The determination of its expression under stress and hormone treatment laid a foundation for further study o
Externí odkaz:
https://doaj.org/article/580e04a989b34e81a34a69dc5494c55a
Autor:
Lidan Wang, Jingping Geng, Linlin Chen, Xiangli Guo, Tao Wang, Yanfen Fang, Bonn Belingon, Jiao Wu, Manman Li, Ying Zhan, Wendou Shang, Yingying Wan, Xuemei Feng, Xianghui Li, Hu Wang
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 386-398 (2022)
The potential of nucleic acid therapeutics to treat diseases by targeting specific cells has resulted in its increasing number of uses in clinical settings. However, the major challenge is to deliver bio-macromolecules into target cells and/or subcel
Externí odkaz:
https://doaj.org/article/97ddbac95b7f491dab3ac3d520c82983
Autor:
Ting He, Yinglei Gao, Yanfen Fang, Yangming Zhang, Shuwei Zhang, Fajun Nan, Jian Ding, Yi Chen
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 8, Pp 1172-1192 (2022)
Objective: The novel compound GCJ-490A has been discovered as a pan-histone deacetylase (HDAC) inhibitor that exerts potent inhibitory activity against HDAC1, HDAC3, and HDAC6. Because of the important roles of HDACs in lung cancer development and th
Externí odkaz:
https://doaj.org/article/129d5544b083412c884b8806ba845ad2
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/7a29c46802c4448cae7897c58da32677
Autor:
Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong, Xiongwen Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more
Externí odkaz:
https://doaj.org/article/94503f7f48fa464aafb2ee8e5f02fe7a
Autor:
Wang Liu, Yu Lu, Xiaoping Chai, Xiao Liu, Tong Zhu, Xihan Wu, Yanfen Fang, Xuan Liu, Xiongwen Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 35, Iss 1, Pp 1-15 (2016)
Abstract Background Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cancer. Here we identified
Externí odkaz:
https://doaj.org/article/39e8d7fd23f743bf9e03d6e0d4e3fa35
Autor:
Chunxiao Miao, Yuanyuan Lv, Wanli Zhang, Xiaoping Chai, Lixing Feng, Yanfen Fang, Xuan Liu, Xiongwen Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Cancer cachexia is a kind of whole body metabolic disorder syndrome accompanied with severe wasting of muscle and adipose tissue. NF-κB signaling plays an important role during skeletal muscle atrophy and fat lipolysis. As an inhibitor of NF-κB sig
Externí odkaz:
https://doaj.org/article/1f59208e8eee4b1b83c748ef00bf481c
Autor:
Zhaohu Lin, Chao Zhang, Meifang Zhang, Danqing Xu, Yanfen Fang, Zheng Zhou, Xiaolong Chen, Ning Qin, Xiongwen Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85296 (2014)
Cadherin-17 (CDH17), one member of 7D-cadherin superfamily, was overexpressed in gastric cancer (GC) and was associated with poor survival, tumor recurrence, metastasis, and advanced tumor stage. So far the cellular function and signaling mechanism o
Externí odkaz:
https://doaj.org/article/e1176d32660a45239026ead60ff55611
Autor:
Yanfen Fang, Like Zhong, Meihua Lin, Xinglu Zhou, Hui Jing, Meidan Ying, Peihua Luo, Bo Yang, Qiaojun He
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66915 (2013)
Dasatinib (BMS-354825) is a FDA-approved multitargeted kinase inhibitor of BCR/ABL and Src kinases. It is now used in the treatment of chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapies, including imatinib. Here we r
Externí odkaz:
https://doaj.org/article/629b6288ab3a4d7ebd61c6ebcd5c7267