Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yanetsy Machado-Tugores"'
Autor:
Alexandra Ibáñez Escribano, Alfredo Meneses Marcel, Yanetsy Machado Tugores, Juan José Nogal Ruiz, Vicente J Arán Redó, José Antonio Escario García-Trevijano, Alicia Gómez Barrio
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 5, Pp 637-643 (2012)
A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more sensitive method to evaluate potential trichomonacidal compounds. Resazurin has been used in recen
Externí odkaz:
https://doaj.org/article/3d54a80d7ae7461d8654683bf4d01c96
Autor:
Alexandra Ibáñez-Escribano, César R. García-Jacas, Yanetsy Machado-Tugores, Alfredo Meneses-Marcel, Juan José Nogal-Ruiz, Vicente J Arán-Redó, Stephen J. Barigye, Enrique Teran, Yovani Marrero-Ponce, Alicia Gómez-Barrio, José Antonio Escario
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Aim: Metronidazole is the most widely used drug in trichomoniasis therapy. However, the emergence of metronidazole-resistant Trichomonas vaginalis isolates calls for the search for new drugs to counter the pathogenicity of these parasites. Results: C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da738f327f15ba2a1180d7cb73e46074
https://pubmed.ncbi.nlm.nih.gov/29589477
https://pubmed.ncbi.nlm.nih.gov/29589477
Autor:
Alicia Barrio, David Montero Pereira, Yanetsy Machado-Tugores, A.R. Martínez-Fernández, Ysaias Alvarado, Juan A. Castillo-Garit, Richard Rotondo, Vicente J. Arán, Froylán Ibarra-Velarde, Juan José Nogal-Ruiz, José Antonio Escario, Francisco Torrens, Alfredo Meneses-Marcel, Yovani Marrero-Ponce
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6502-6524
Existing Trichomonas vaginalis therapies are out of reach for most trichomoniasis people in developing countries and, where available, they are limited by their toxicity (mainly in pregnant women) and their cost. New antitrichomonal agents are needed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0ee91404de3cf5fb86e7f1e0caef65
https://doi.org/10.1016/j.bmc.2006.06.016
https://doi.org/10.1016/j.bmc.2006.06.016
Autor:
Carmen Ochoa, Yovani Marrero-Ponce, Yanetsy Machado-Tugores, A.R. Martínez-Fernández, Rory N. García-Sánchez, Vicente J. Arán, Alina Montero-Torres, Juan José Nogal-Ruiz, Alfredo Meneses-Marcel, Francisco Torrens
Publikováno v:
European Journal of Medicinal Chemistry. 41:483-493
In order to explore the ability of non-stochastic quadratic indices to encode chemical information in antimalarials, four quantitative models for the discrimination of compounds having this property were generated and statistically compared. Accuraci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f39658202d2e1e69886a087a4b8834
https://doi.org/10.1016/j.ejmech.2005.12.010
https://doi.org/10.1016/j.ejmech.2005.12.010
Autor:
A.R. Martínez-Fernández, Maria Gabriela Cabrera-Serra, Jan Tytgat, Norma Rivera, Facundo Pérez-Giménez, José E. Piñero, Roberto Chicharro, Ramón García-Domenech, Rory N. García-Sánchez, Miriam Rolón, Vicente J. Arán, Ricardo Mondragón, Atteneri López-Arencibia, Yovani Marrero-Ponce, Miriam A. Martins Alho, Jacob Lorenzo-Morales, Alina Montero-Torres, Stephen J. Barigye, Carmen M. Martín-Navarro, Froylán Ibarra-Velarde, Juan José Nogal, Maria Celeste Vega, Mónica Mondragón, Alicia Gómez-Barrio, José Antonio Escario, Alfredo Meneses-Marcel, Yanetsy Machado Tugores
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
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Protozoan parasites have been one of the most significant public health problems for centuries and several human infections caused by them have massive global impact. Most of the current drugs used to treat these illnesses have been used for decades
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a68fe42fda2b6e7b7182e6d06671a2
http://hdl.handle.net/10261/93642
http://hdl.handle.net/10261/93642
Autor:
Alicia Barrio, Alfredo Irenaldo Meneses Marcel, Vicente J Arán Redó, Yanetsy Machado Tugores, José Antonio Escario Garcia-Trevijano, Alexandra Ibáñez Escribano, Juan José Nogal Ruiz
Publikováno v:
Memórias do Instituto Oswaldo Cruz, Volume: 107, Issue: 5, Pages: 637-643, Published: AUG 2012
Memórias do Instituto Oswaldo Cruz., Vol 107, Iss 5, Pp 637-643 (2012)
Memórias do Instituto Oswaldo Cruz., Vol 107, Iss 5, Pp 637-643 (2012)
A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more sensitive method to evaluate potential trichomonacidal compounds. Resazurin has been used in recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fde6c3a9e4c97a3cb7e3ffc2388f754
https://pubmed.ncbi.nlm.nih.gov/22850954
https://pubmed.ncbi.nlm.nih.gov/22850954
Autor:
Maria Celeste Vega, Ricardo Mondragón, Juan José Nogal, Miriam A. Martins Alho, Yanetsy Machado Tugores, A.R. Martínez-Fernández, Miriam Rolón, Vicente J. Arán, Alina Montero-Torres, Yovani Marrero-Ponce, Froylán Ibarra-Velarde, Rory N. García-Sánchez, Alicia Gómez-Barrio, José Antonio Escario, Mónica Mondragón, Alfredo Meneses-Marcel, Roberto Chicharro, Norma Rivera, Facundo Pérez-Giménez
Publikováno v:
Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db7bdad62ed0b8c287cb51213bea2edb
https://doi.org/10.3390/ecsoc-12-01246
https://doi.org/10.3390/ecsoc-12-01246
Autor:
Alfredo Meneses-Marcel, David Montero Pereira, Francisco Torrens, José Antonio Escario, Vicente J. Arán, Alina Montero, Oscar Miguel Rivera-Borroto, Ricardo Grau, Vladimir V. Kouznetsov, Yanetsy Machado Tugores, Arnold R. Romero Bohórquez, Cristian Ochoa Puentes, Alicia Barrio, Yovani Marrero-Ponce, Froylán Ibarra-Velarde, Juan José Nogal
Publikováno v:
Journal of biomolecular screening. 13(8)
Bond-based quadratic indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis (LDA) were used to discover novel lead trichomonacidals. The obtained LDA-based quantitative structure-activity relationships (QSAR) models, usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fe6f5d3b1ae39e2a5d1b1abb71efb3
https://pubmed.ncbi.nlm.nih.gov/18753687
https://pubmed.ncbi.nlm.nih.gov/18753687
Autor:
Alfredo Meneses-Marcel, Juan José Nogal-Ruiz, Carmen Ochoa, Alina Montero-Torres, Yovani Marrero-Ponce, José Antonio Escario, Vicente J. Arán, A.R. Martínez-Fernández, Francisco Torrens, David Montero Pereira, Alicia Barrio, Yanetsy Machado-Tugores, Rory N. García Sánchez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
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Computational approaches are developed to design or rationally select, from structural databases, new lead trichomonacidal compounds. First, a data set of 111 compounds was split (design) into training and predicting series using hierarchical and par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4610739a9038c7c480e9973d431f76ab
http://hdl.handle.net/10261/87256
http://hdl.handle.net/10261/87256
Autor:
Vicente J. Arán, Yovani Marrero-Ponce, Alfredo Meneses-Marcel, A.R. Martínez-Fernández, Rory N. García Sánchez, Carmen Ochoa, Juan José Nogal-Ruiz, José Antonio Escario, Yanetsy Machado-Tugores, Alina Montero-Torres, David Montero Pereira
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
A computational (virtual) screening test to identify potential trichomonacidals has been developed. Molecular structures of trichomonacidal and non-trichomonacidal drugs were represented using stochastic and non-stochastic atom-based quadratic indice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384797976d562b2765492c8a3b6084ac
http://hdl.handle.net/10261/87339
http://hdl.handle.net/10261/87339