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Abstract 176: The Evolution of NANOGP8 and its possible roles in tumorigenesis

Autor: Yande Guo

Publikováno v: Cancer Research. 80:176-176

Human NANOG gene is located in Chromosome 12p13. It is a transcription factor in embryonic stem cells. There are 11 NANOG pseudogenes in human genome. NANOGP1 is an unprocessed pseudogene that arose through duplication of the chromosomal region conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e68038a3795e1897a77332c1cd18e99b
https://doi.org/10.1158/1538-7445.am2020-176

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Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasionviaactivation of PI3K/Akt/NF-κB

Autor: Stephanie C. Tucker, Ashok Kumar Dilly, Yinlong Cai, Mustapha Kandouz, Prasanna Ekambaram, Kenneth V. Honn, Yande Guo, Rafael Fridman

Publikováno v: International Journal of Cancer. 133:1784-1791

Prostate cancer is the most frequently diagnosed cancer and the second leading cause of death in males in the United States. Using human prostate cancer specimens, the authors have previously shown that elevated expression levels of 12-lipoxygenase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72effa3077648438a3b2150d38d7102e
https://doi.org/10.1002/ijc.28165

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Convergence of Eicosanoid and Integrin Biology: Role of Src in 12-LOX activation

Autor: Yinlong Cai, Krishna Rao Maddipati, Kenneth V. Honn, Ashok Kumar Dilly, Sangeeta Joshi, Keqin Tang, Yande Guo, Stephanie C. Tucker, Prasanna Ekambaram

12-Lipoxygenase (12-LOX) metabolizes arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, or 12(S)-HETE, a proinflammatory bioactive lipid implicated in tumor angiogenesis, growth, and metastasis. The mechanisms underlying 12-LOX-mediated signalin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd2369923267673f7eeb3ef8e2307f5
https://europepmc.org/articles/PMC5303182/

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Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

Autor: Ashok Kumar Dilly, Jingjing Liu, Wenliang Zhang, Craig N. Giroux, Menq Jer Lee, Sangeeta Joshi, Kenneth V. Honn, Stephanie C. Tucker, Prasanna Ekambaram, Yande Guo, Yinlong Cai, Andrew Hsu, Senlin Zhou, Krishna Rao Maddipati

Publikováno v: Journal of Biological Chemistry. 286:33832-33840

Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions. We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor that displays high affinity for the human 12-lipoxygenase-derived pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65ef20e33d04030b0eb687187b7ed19
https://doi.org/10.1074/jbc.m110.216564

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Abstract 2463: Long noncoding RNAs in tumor responses toward lovastatin

Autor: Entkhab M. Alanisi, Daotai Nie, Jiuhui Wang, Yande Guo

Publikováno v: Cancer Research. 78:2463-2463

Background: Lovastatin is one of FDA-approved drugs used to treat hypercholesterolemia to reduce cardiovascular diseases. It is a compound of the statin family derived from type of species of Aspergillus terruses. Lovastatin targets hepatocytes and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::531a99bf79c6c402374643da8e27321f
https://doi.org/10.1158/1538-7445.am2018-2463

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Thromboxane A2 Receptors in Prostate Carcinoma: Expression and Its Role in Regulating Cell Motility via Small GTPase Rho

Autor: Alex Zacharek, Yande Guo, Yong Tang, Kenneth V. Honn, Mingxin Che, Man Tzu Wang, Daotai Nie, Yakun Chen, Yan Qiao, Dianer Yang

Publikováno v: Cancer Research. 68:115-121

Thromboxane A2 (TxA2) is a prostanoid formed by thromboxane synthase using the cyclooxygenase product prostaglandin H2 as the substrate. Previously, increased expression of thromboxane synthase was found in prostate tumors, and tumor cell motility wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811b82693a8779eaecbe37ed0d46d40c
https://doi.org/10.1158/0008-5472.can-07-1018

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Mechanisms Regulating Tumor Angiogenesis by 12-Lipoxygenase in Prostate Cancer Cells

Autor: Kenneth V. Honn, Alex Zacharek, Daotai Nie, Julie Milanini, Rongxian Jin, Gilles Pagès, Keqin Tang, Yande Guo, Yan Qiao, YuChyu Chen, Sriram Krishnamoorthy

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. ⟨10.1074/jbc.M601887200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. 〈10.1074/jbc.M601887200〉

International audience; 12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promotes tumorigenesis and metastasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb23aa65f5113defe54dcf457969991
https://doi.org/10.1074/jbc.m601887200

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Transport of inorganic phosphate in primary cultures of chondrocytes isolated from the tibial growth plate of normal adolescent chickens

Autor: Licia N.Y. Wu, Roy E. Wuthier, Yande Guo, Yoshinori Ishikawa, Brian R. Genge

Publikováno v: Journal of Cellular Biochemistry. 86:475-489

This report describes Pi transport activity in chondrocytes isolated from the growth plate (GP) of normal adolescent chickens grown in primary cell culture. Our recent work showed that Pi transport in matrix vesicles (MV) isolated from normal GP cart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce14dd09143994a6e863a50b92f0b69
https://doi.org/10.1002/jcb.10240

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