12‐HETER1/GPR31, a high‐affinity 12( S )‐hydroxyeicosatetraenoic acid receptor, is significantly up‐regulated in prostate cancer and plays a critical role in prostate cancer progression

Autor: Menq Jer Lee, Gregory Dyson, Yande Guo, Stephanie C. Tucker, Yinlong Cai, Kenneth V. Honn, Wenliang Zhang

Publikováno v: The FASEB Journal. 30:2360-2369

Previously we identified and deorphaned G-protein-coupled receptor 31 (GPR31) as the high-affinity 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] receptor (12-HETER1). Here we have determined its distribution in prostate cancer tissue and its role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd1dc673cf074e8a7e7c02e15fb8ae8
https://doi.org/10.1096/fj.201500076

Platelet-type 12-lipoxygenase induces MMP9 expression and cellular invasionviaactivation of PI3K/Akt/NF-κB

Autor: Stephanie C. Tucker, Ashok Kumar Dilly, Yinlong Cai, Mustapha Kandouz, Prasanna Ekambaram, Kenneth V. Honn, Yande Guo, Rafael Fridman

Publikováno v: International Journal of Cancer. 133:1784-1791

Prostate cancer is the most frequently diagnosed cancer and the second leading cause of death in males in the United States. Using human prostate cancer specimens, the authors have previously shown that elevated expression levels of 12-lipoxygenase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72effa3077648438a3b2150d38d7102e
https://doi.org/10.1002/ijc.28165

Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid

Autor: Ashok Kumar Dilly, Jingjing Liu, Wenliang Zhang, Craig N. Giroux, Menq Jer Lee, Sangeeta Joshi, Kenneth V. Honn, Stephanie C. Tucker, Prasanna Ekambaram, Yande Guo, Yinlong Cai, Andrew Hsu, Senlin Zhou, Krishna Rao Maddipati

Publikováno v: Journal of Biological Chemistry. 286:33832-33840

Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions. We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor that displays high affinity for the human 12-lipoxygenase-derived pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65ef20e33d04030b0eb687187b7ed19
https://doi.org/10.1074/jbc.m110.216564

Mechanisms Regulating Tumor Angiogenesis by 12-Lipoxygenase in Prostate Cancer Cells

Autor: Kenneth V. Honn, Alex Zacharek, Daotai Nie, Julie Milanini, Rongxian Jin, Gilles Pagès, Keqin Tang, Yande Guo, Yan Qiao, YuChyu Chen, Sriram Krishnamoorthy

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. ⟨10.1074/jbc.M601887200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (27), pp.18601-9. 〈10.1074/jbc.M601887200〉

International audience; 12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end product 12(S)-hydroxyeicosatetraenoic acid, an eicosanoid that promotes tumorigenesis and metastasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb23aa65f5113defe54dcf457969991
https://doi.org/10.1074/jbc.m601887200

Transport of inorganic phosphate in primary cultures of chondrocytes isolated from the tibial growth plate of normal adolescent chickens

Autor: Licia N.Y. Wu, Roy E. Wuthier, Yande Guo, Yoshinori Ishikawa, Brian R. Genge

Publikováno v: Journal of Cellular Biochemistry. 86:475-489

This report describes Pi transport activity in chondrocytes isolated from the growth plate (GP) of normal adolescent chickens grown in primary cell culture. Our recent work showed that Pi transport in matrix vesicles (MV) isolated from normal GP cart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce14dd09143994a6e863a50b92f0b69
https://doi.org/10.1002/jcb.10240