A noncoding single-nucleotide polymorphism at 8q24 drives IDH1 -mutant glioma formation.

Autor: Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Drucker KL; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kollmeyer TM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Winick-Ng W; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany., Liang M; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Pawling J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., De Lorenzo SB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Ali A; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Kosel ML; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Panda A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Jiang L; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Browning JWL; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lowden C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Geuenich M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Hernandez JJ; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Gosio JT; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Berman J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Michealraj KA; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Fortin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Carson B; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Hollingsworth EW; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jacinto S; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Mazrooei P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zhou L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Murphy DJ; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, Scotland, UK.; Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, UK., Wang L; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Abyzov A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Dennis JW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Maass PG; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Campbell K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Lachance DH; Departments of Neurology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Wrensch M; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Wiencke J; Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA., Mak T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Pennacchio LA; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA., Dickel DE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA., Visel A; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, USA.; US Department of Energy Joint Genome Institute, Berkeley, CA 94720, USA.; School of Natural Sciences, University of California, Merced, CA 95343, USA., Wrana J; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Taylor MD; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Zadeh G; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Dirks P; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada., Pombo A; Max-Delbrück Centre for Molecular Medicine, Berlin Institute for Medical Systems Biology, Epigenetic Regulation and Chromatin Architecture Group, 13092 Berlin, Germany.; Institute of Biology, Humboldt University of Berlin, 10115 Berlin, Germany., Ida CM; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Kvon EZ; Department of Developmental and Cell Biology, University of California, Irvine, CA 92617, USA., Jenkins RB; Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. 68-78. Date of Electronic Publication: 2022 Oct 06.

Discovering Potential in Non-Cancer Medications: A Promising Breakthrough for Multiple Myeloma Patients.

Autor: Al-Odat, Omar S.^1,2 (AUTHOR) jonnalagadda@rowan.edu, Nelson, Emily^1,2 (AUTHOR) nelson52@students.rowan.edu, Budak-Alpdogan, Tulin³ (AUTHOR) budak-alpdogan-tulin@cooperhealth.edu, Jonnalagadda, Subash C.² (AUTHOR), Desai, Dhimant⁴ (AUTHOR) ddesai@pennstatehealth.psu.edu, Pandey, Manoj K.¹ (AUTHOR) pandey@rowan.edu

Publikováno v: Cancers. Jul2024, Vol. 16 Issue 13, p2381. 21p.

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci.

Autor: Chylinski K; Vienna Biocenter Core Facilities, Vienna Biocenter (VBC), Dr. Bohr Gasse 3, Vienna, Austria., Hubmann M; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Hanna RE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Michlits G; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Uijttewaal ECH; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Doench J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Elling U; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria. ulrich.elling@imba.oeaw.ac.at.

Publikováno v: Nature communications [Nat Commun] 2019 Nov 29; Vol. 10 (1), pp. 5454. Date of Electronic Publication: 2019 Nov 29.

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics.

Autor: Hernandez JJ; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Pryszlak M; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; The Hospital for Sick Children, Toronto, ON, Canada., Smith L; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; The Hospital for Sick Children, Toronto, ON, Canada., Yanchus C; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada., Kurji N; Cyclica Inc., Toronto, ON, Canada., Shahani VM; Cyclica Inc., Toronto, ON, Canada., Molinski SV; Cyclica Inc., Toronto, ON, Canada.

Publikováno v: Frontiers in oncology [Front Oncol] 2017 Nov 14; Vol. 7, pp. 273. Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer.

Autor: De Sousa-Coelho, Ana Luísa^1,2,3 (AUTHOR) alcoelho@ualg.pt, Fraqueza, Gil^4,5 (AUTHOR) gfraque@ualg.pt, Aureliano, Manuel^5,6 (AUTHOR) alcoelho@ualg.pt

Publikováno v: Pharmaceuticals (14248247). Jan2024, Vol. 17 Issue 1, p12. 14p.