Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Yanai Duran"'
Autor:
Paul V. Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B. Graca, Claire Hippert, Nozie D. Aghaizu, Aikaterini A. Kalargyrou, Amanda C. Barber, Giulia Grimaldi, Yanai Duran, Samuel J.I. Blackford, Magdalena Kloc, Debbie Goh, Eduardo Zabala Aldunate, Robert D. Sampson, James W.B. Bainbridge, Alexander J. Smith, Anai Gonzalez-Cordero, Jane C. Sowden, Robin R. Ali, Rachael A. Pearson
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 406-421 (2018)
Summary: Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process previously underst
Externí odkaz:
https://doaj.org/article/9c09c8d9a3254109b4487e9be40e1549
Autor:
Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J.I. Blackford, Laura Abelleira-Hervas, Robert D. Sampson, Ian O. Shum, Matthew J. Branch, Peter J. Gardner, Jane C. Sowden, James W.B. Bainbridge, Alexander J. Smith, Emma L. West, Rachael A. Pearson, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 820-837 (2017)
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that
Externí odkaz:
https://doaj.org/article/8a49ca1b0cdf4a038147dab24006d255
Autor:
Kamil Kruczek, Anai Gonzalez-Cordero, Debbie Goh, Arifa Naeem, Mindaugas Jonikas, Samuel J.I. Blackford, Magdalena Kloc, Yanai Duran, Anastasios Georgiadis, Robert D. Sampson, Ryea N. Maswood, Alexander J. Smith, Sarah Decembrini, Yvan Arsenijevic, Jane C. Sowden, Rachael A. Pearson, Emma L. West, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1659-1674 (2017)
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy. Here, we characterize cone differentiation in retinas derived f
Externí odkaz:
https://doaj.org/article/4b46b88060114033ab080d3c4bf48091
Autor:
Pilar Villacampa, Katja E Menger, Laura Abelleira, Joana Ribeiro, Yanai Duran, Alexander J Smith, Robin R Ali, Ulrich F Luhmann, James W B Bainbridge
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179759 (2017)
Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We
Externí odkaz:
https://doaj.org/article/f05d364bb4304162a5572ab0949cbfda
Autor:
Prateek K Buch, Marija Mihelec, Phillippa Cottrill, Susan E Wilkie, Rachael A Pearson, Yanai Duran, Emma L West, Michel Michaelides, Robin R Ali, David M Hunt
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18089 (2011)
Cone dystrophy 3 (COD3) is a severe dominantly inherited retinal degeneration caused by missense mutations in GUCA1A, the gene encoding Guanylate Cyclase Activating Protein 1 (GCAP1). The role of GCAP1 in controlling cyclic nucleotide levels in photo
Externí odkaz:
https://doaj.org/article/3658d5bde1d24913974288c86057c43f
Autor:
Freya M Mowat, Ulrich F O Luhmann, Alexander J Smith, Clemens Lange, Yanai Duran, Sarah Harten, Deepa Shukla, Patrick H Maxwell, Robin R Ali, James W B Bainbridge
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11103 (2010)
Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse range of
Externí odkaz:
https://doaj.org/article/2c62aac77b2e4cd79c86b579d4b6a3b7
Autor:
Robin R. Ali, Dalila Bevilacqua, Dimitra Athanasiou, Mònica Aguilà, Takao Iwawaki, Alexander J. Smith, James Bellingham, David A. Parfitt, Ryea Maswood, Michael E. Cheetham, Yanai Duran, Giannis Spyrou
Publikováno v:
Human Molecular Genetics
Rhodopsin misfolding caused by the P23H mutation is a major cause of autosomal dominant retinitis pigmentosa (adRP). To date, there are no effective treatments for adRP. The BiP co-chaperone and reductase ERdj5 (DNAJC10) is part of the endoplasmic re
Autor:
Robin R. Ali, Maeve Barlow, James W B Bainbridge, Enrico Cristante, Sidath E. Liyanage, Yanai Duran, Pilar Villacampa, Katja E. Menger, Laura Abelleira-Hervas, Izabela P Klaska, Robert D. Sampson, Ulrich F O Luhmann, Alexander J. Smith
Publikováno v:
Angiogenesis
The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascul
Autor:
Aikaterini A. Kalargyrou, Alexander J. Smith, Ryea Maswood, Giulia De Rossi, Takaaki Matsuki, Robert D. Sampson, Ulrich F O Luhmann, Enrico Cristante, Yanai Duran, Matteo Rizzi, Joana Ribeiro, James W B Bainbridge, Robin R. Ali, Justin Hoke, Nozie D. Aghaizu, Sidath E. Liyanage
In the adult central nervous system, endothelial and neuronal cells engage in tight cross-talk as key components of the so-called neurovascular unit. Impairment of their critical relationship adversely affects tissue homeostasis, as observed in neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41a15a80f7a43f4a692d911db2845a0
https://europepmc.org/articles/PMC5964651/
https://europepmc.org/articles/PMC5964651/
Autor:
Joana Ribeiro, Robert D. Sampson, Ulrich F O Luhmann, Matteo Rizzi, Anastasios Georgiadis, Robin R. Ali, Selina A. Azam, Justin Hoke, Ryea Maswood, Sophia-Martha Kleine Holthaus, Rachael A. Pearson, Laura Abelleira-Hervas, Sara E. Mole, Alexander J. Smith, Yanai Duran
Publikováno v:
Molecular Therapy
The neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage disorders characterized by general neurodegeneration and premature death. Sight loss is also a major symptom in NCLs, severely affecting the quality of life of patients, but it