Exploring Refinement Strategies for Single Housing of Male C57BL/6JRj Mice: Effect of Cage Divider on Stress-Related Behavior and Hypothalamic-Pituitary-Adrenal-Axis Activity

Autor: An Buckinx, Andries Van Schuerbeek, Jo Bossuyt, Wissal Allaoui, Yana Van Den Herrewegen, Ilse Smolders, Dimitri De Bundel

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 15 (2021)

Introduction: Single housing of laboratory mice is a common practice to meet experimental needs, or to avoid intermale aggression. However, single housing is considered to negatively affect animal welfare and may compromise the scientific validity of

Externí odkaz: https://doaj.org/article/5707ef504c6c49f6b65963d991d48bd5

Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy

Autor: Ilse Julia Smolders, Dimitri De Bundel, Eckhard Guenther, Ron Kooijman, Yana Van Den Herrewegen, An Buckinx, Anouk Pierre, Gaetan Van Laethem, Matthias Gerlach

Publikováno v: European Journal of Neurology. 28:3100-3112

Background Current drugs for epilepsy affect seizures, but no antiepileptogenic or disease-modifying drugs are available that prevent or slow down epileptogenesis, which is characterized by neuronal cell loss, inflammation and aberrant network format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a417a4cdcc3d4ef7c2e2e120048f29d
https://doi.org/10.1111/ene.14992

Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1

Autor: Dimitri De Bundel, Ilse Julia Smolders, Thomas M. Sanderson, Surajit Sahu, Zuner A. Bortolotto, Yana Van Den Herrewegen

Publikováno v: Molecular Brain
Molecular Brain, Vol 14, Iss 1, Pp 1-13 (2021)
Van Den Herrewegen, Y, Sanderson, T M, Sahu, S, De Bundel, D, Bortolotto, Z A & Smolders, I 2021, ' Side-by-side comparison of the effects of Gq-and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1 ', Molecular Brain, vol. 14, no. 1, 144, pp. 1-13 . https://doi.org/10.1186/s13041-021-00856-w

Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient variations in intracellular Ca2+. In addition, Ca2+-dependent and/or Ca2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e97733bcfd49b916aa371ad96cdc7e
http://europepmc.org/articles/PMC8451082

The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy

Autor: Yana Van Den Herrewegen, Giulia Albertini, Lissa Denewet, Ann Van Eeckhaut, Ilse Julia Smolders, An Buckinx, Dimitri De Bundel

Temporal lobe epilepsy (TLE) is an acquired form of focal epilepsy, in which patients not only suffer from unprovoked, devastating seizures, but also from severe comorbidities, such as cognitive dysfunction. Correspondingly, several animal models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e565f674b1da066f24281cc1c0f3fa7
https://hdl.handle.net/20.500.14017/f4be2523-e1d3-4a42-bbdc-e015e08f63c6

CHEMOGENETIC MODULATION OF ASTROCYTES IN A MODEL FOR TEMPORAL LOBE EPILEPSY

Autor: An Buckinx, Ann Van Eeckhaut, Ilse Julia Smolders, Dimitri De Bundel, Yana Van Den Herrewegen

Publikováno v: Vrije Universiteit Brussel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832f7eaac66ef674fc7dfceadaf34655
https://researchportal.vub.be/en/publications/30587e5b-f4a9-42d6-87fc-bc0373cbe923