Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yana Shadkchan"'
Autor:
Duaa Anabosi, Zohar Meir, Yana Shadkchan, Mariana Handelman, Ammar Abou-Kandil, Annie Yap, Daniel Urlings, Morgan S. Gold, Sven Krappmann, Hubertus Haas, Nir Osherov
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 2186-2200 (2021)
Aspergillus fumigatus is the leading cause of life-threatening invasive mold infections in immunocompromised individuals. This ubiquitous saprophyte possesses several natural attributes allowing it to evade the immune system, including the ability to
Externí odkaz:
https://doaj.org/article/b36694be212d4034bf7dbe25b2a07ff7
Autor:
Mario Aguiar, Thomas Orasch, Yana Shadkchan, Patricia Caballero, Joachim Pfister, Luis Enrique Sastré-Velásquez, Fabio Gsaller, Clemens Decristoforo, Nir Osherov, Hubertus Haas
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Siderophores play an important role in fungal virulence, serving as trackers for in vivo imaging and as biomarkers of fungal infections. However, siderophore uptake is only partially characterized. As the major cause of aspergillosis, Asperg
Externí odkaz:
https://doaj.org/article/fc6bc1dd47b144078ad2051d647d196d
Autor:
Thomas Orasch, Anna-Maria Dietl, Yana Shadkchan, Ulrike Binder, Ingo Bauer, Cornelia Lass-Flörl, Nir Osherov, Hubertus Haas
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 925-934 (2019)
In contrast to mammalia, fungi are able to synthesize the branched-chain amino acid leucine de novo. Recently, the transcription factor LeuB has been shown to cross-regulate leucine biosynthesis, nitrogen metabolism and iron homeostasis in Aspergillu
Externí odkaz:
https://doaj.org/article/dae059ba5a384f48b7621b5c1330a22d
Autor:
Kunlong Yang, Yana Shadkchan, Joanna Tannous, Julio A. Landero Figueroa, Philipp Wiemann, Nir Osherov, Shihua Wang, Nancy P. Keller
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1273-1286 (2018)
The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the second most frequent Aspergillus pathogen after A. fumigatus infecting im
Externí odkaz:
https://doaj.org/article/9694c3686e944b1d8b41462f4b37c11b
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The identification of cellular targets for antifungal compounds is a cornerstone for the development of novel antimycotics, for which a significant need exists due to increasing numbers of susceptible patients, emerging pathogens, and evolving resist
Externí odkaz:
https://doaj.org/article/7973dc5fe8394ef2bbf347e3f47514af
Autor:
Ingo Bauer, Matthias Misslinger, Yana Shadkchan, Anna-Maria Dietl, Verena Petzer, Thomas Orasch, Beate Abt, Stefan Graessle, Nir Osherov, Hubertus Haas
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Current suboptimal treatment options of invasive fungal infections and emerging resistance of the corresponding pathogens urge the need for alternative therapy strategies and require the identification of novel antifungal targets. Aspergillus fumigat
Externí odkaz:
https://doaj.org/article/6beb846ebc9d4ba983f5d6b67108fe7e
Autor:
Philipp Wiemann, Adi Perevitsky, Fang Yun Lim, Yana Shadkchan, Benjamin P. Knox, Julio A. Landero Figueora, Tsokyi Choera, Mengyao Niu, Andrew J. Steinberger, Marcel Wüthrich, Rachel A. Idol, Bruce S. Klein, Mary C. Dinauer, Anna Huttenlocher, Nir Osherov, Nancy P. Keller
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 1008-1021 (2017)
Summary: The Fenton-chemistry-generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive
Externí odkaz:
https://doaj.org/article/153c382f8c2f412281161132bf7a71b6
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The saprophytic mold Aspergillus fumigatus is the most common airborne fungal pathogen causing severe invasive fungal infections in immunocompromised patients. Siroheme is a heme-like prosthetic group used by plants and microorganisms for sulfate and
Externí odkaz:
https://doaj.org/article/23f6ab815ce04a07aa8e1091868cf3b0
Publikováno v:
Genes, Vol 11, Iss 4, p 423 (2020)
Aspergillus fumigatus is an opportunistic human pathogen mainly infecting immunocompromised patients. The aim of this study was to characterize the role of arginine biosynthesis in virulence of A. fumigatus via genetic inactivation of two key arginin
Externí odkaz:
https://doaj.org/article/938723c3c45243b1af97e7e964e23b33
Autor:
Einav Shemesh, Benjamin Hanf, Shelly Hagag, Shani Attias, Yana Shadkchan, Boris Fichtman, Amnon Harel, Thomas Krüger, Axel A. Brakhage, Olaf Kniemeyer, Nir Osherov
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Aspergillus fumigatus is the most common mold species to cause disease in immunocompromised patients. Infection usually begins when its spores (conidia) are inhaled into the airways, where they germinate, forming hyphae that penetrate and destroy the
Externí odkaz:
https://doaj.org/article/cefcedf1cfac47b1825bcec4dc15bc98