Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yana Safonova"'
Autor:
Oscar L. Rodriguez, Yana Safonova, Catherine A. Silver, Kaitlyn Shields, William S. Gibson, Justin T. Kos, David Tieri, Hanzhong Ke, Katherine J. L. Jackson, Scott D. Boyd, Melissa L. Smith, Wayne A. Marasco, Corey T. Watson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibodie
Externí odkaz:
https://doaj.org/article/a0183aabadc24385b06da65e954df467
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Affinity maturation (AM) of B cells through somatic hypermutations (SHMs) enables the immune system to evolve to recognize diverse pathogens. The accumulation of SHMs leads to the formation of clonal lineages of antibody-secreting b cells that have e
Externí odkaz:
https://doaj.org/article/b4e5b443c2d14eeca8d5bff118728902
Autor:
Jeong Hyun Lee, Laura Toy, Justin T. Kos, Yana Safonova, William R. Schief, Colin Havenar-Daughton, Corey T. Watson, Shane Crotty
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
Abstract A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome the hurdle of being able to activate naive precursor B cells encoding features within their germline B cell receptors (BCR) that allow recognition of br
Externí odkaz:
https://doaj.org/article/996c49bfefaf45c393289c1cfe6ce853
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007837 (2020)
Immunoglobulin genes are formed through V(D)J recombination, which joins the variable (V), diversity (D), and joining (J) germline genes. Since variations in germline genes have been linked to various diseases, personalized immunogenomics focuses on
Externí odkaz:
https://doaj.org/article/c2cbb9952bdc44a882f833725872421b
Autor:
Yana Safonova, Pavel A. Pevzner
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The V(D)J recombination forms the immunoglobulin genes by joining the variable (V), diversity (D), and joining (J) germline genes. Since variations in germline genes have been linked to various diseases, personalized immunogenomics aims at finding al
Externí odkaz:
https://doaj.org/article/bc13f5ff564e47a2a63306e592ac246c
Autor:
Ge Song, Meng Yuan, Hejun Liu, Tazio Capozzola, Ryan N. Lin, Jonathan L. Torres, Wan-ting He, Rami Musharrafieh, Katharina Dueker, Panpan Zhou, Sean Callaghan, Nitesh Mishra, Peter Yong, Fabio Anzanello, Gabriel Avillion, Anh Lina Vo, Xuduo Li, Muzamil Makhdoomi, Ziqi Feng, Xueyong Zhu, Linghang Peng, David Nemazee, Yana Safonova, Bryan Briney, Andrew B Ward, Dennis R. Burton, Ian A. Wilson, Raiees Andrabi
SummaryDeveloping broad coronavirus vaccines requires identifying and understanding the molecular basis of broadly neutralizing antibody (bnAb) spike sites. In our previous work, we identified sarbecovirus spike RBD group 1 and 2 bnAbs. We have now s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f92bd3fd46654615a9bae37b36da959
https://doi.org/10.1101/2023.04.26.538488
https://doi.org/10.1101/2023.04.26.538488
Autor:
Yana Safonova, Sung Bong Shin, Luke Kramer, James Reecy, Corey T. Watson, Timothy P.L. Smith, Pavel A. Pevzner
Publikováno v:
Genome Research. 32:791-804
An important challenge in vaccine development is to figure out why a vaccine succeeds in some individuals and fails in others. Although antibody repertoires hold the key to answering this question, there have been very few personalized immunogenomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c47eab1e1a15fad21fe9b13b32cca
https://doi.org/10.1101/gr.276027.121
https://doi.org/10.1101/gr.276027.121
Autor:
Maria Pospelova, Yana Safonova
HIV-1 infects a subset of immune cells identified by the receptor CD4 and a coreceptor, CCR5 or CXCR4. Previous studies revealed bnAbs against HIV-1 with antigen-binding sites mimicking binding sites of CCR5. Such antibodies are characterized by post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043666910d90a9f6b04fb8cbe94e92b4
https://doi.org/10.1101/2022.12.13.520330
https://doi.org/10.1101/2022.12.13.520330
Autor:
Shane Crotty, Justin T. Kos, William R. Schief, Colin Havenar-Daughton, Yana Safonova, Jeong Hyun Lee, Laura Toy, Corey T. Watson
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-12 (2021)
NPJ Vaccines
NPJ Vaccines
A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome the hurdle of being able to activate naive precursor B cells encoding features within their germline B cell receptors (BCR) that allow recognition of broadly neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf4f7cfde323a7ad555284a83cc3cba
https://doaj.org/article/996c49bfefaf45c393289c1cfe6ce853
https://doaj.org/article/996c49bfefaf45c393289c1cfe6ce853
Autor:
Wan-ting He, Meng Yuan, Sean Callaghan, Rami Musharrafieh, Ge Song, Murillo Silva, Nathan Beutler, Wen-Hsin Lee, Peter Yong, Jonathan L. Torres, Mariane Melo, Panpan Zhou, Fangzhu Zhao, Xueyong Zhu, Linghang Peng, Deli Huang, Fabio Anzanello, James Ricketts, Mara Parren, Elijah Garcia, Melissa Ferguson, William Rinaldi, Stephen A. Rawlings, David Nemazee, Davey M. Smith, Bryan Briney, Yana Safonova, Thomas F. Rogers, Jennifer M. Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Darrell J. Irvine, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Raiees Andrabi
Publikováno v:
Science translational medicine, vol 14, iss 657
To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that immunization of macaques with SARS-CoV-2 spike (S) protein with a two-sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbe0b629f7acc51806315f775b5c888
https://doi.org/10.1126/scitranslmed.abl9605
https://doi.org/10.1126/scitranslmed.abl9605