Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

Autor: Gerardo Z. Lederkremer, Nir Ben-Tal, Navit Ogen Shtern, Yana Gofman, Marina Shenkman, Julia Leitman, Linda M. Hendershot

Publikováno v: Molecular Biology of the Cell

The unfolded protein response PERK branch induces recruitment of misfolded proteins and the ubiquitin ligase HRD1 to the ER-derived quality control compartment (ERQC), a staging ground for ER-associated degradation (ERAD). This is accomplished by up-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2762a2a6c5e78109bf85aa6a93ec22bb
http://europepmc.org/articles/PMC3967970

Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors

Autor: Doron Rapaport, Alexej Kedrov, Nir Ben-Tal, Yechiel Shai, Yana Gofman, Arnold J. M. Driessen, Elisa Merklinger

Publikováno v: Biochemical Journal, 442(2), 381-389. PORTLAND PRESS LTD

The MOM (mitochondrial outer membrane) contains SA (signal-anchored) proteins that bear at their N-terminus a single hydrophobic segment that serves as both a mitochondrial targeting signal and an anchor at the membrane. These proteins, like the vast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb49b18ca41f90c587d161dcddc95717
https://research.rug.nl/en/publications/afedc712-c246-4ba6-9638-9fda3370c175

Structure, dynamics and implied gating mechanism of a human cyclic nucleotide-gated channel

Autor: Nir Ben-Tal, Turkan Haliloglu, Debora S. Marks, Yana Gofman, Charlotta P I Schärfe

Publikováno v: PLoS Computational Biology, Vol 10, Iss 12, p e1003976 (2014)
PLoS Computational Biology

Cyclic nucleotide-gated (CNG) ion channels are nonselective cation channels, essential for visual and olfactory sensory transduction. Although the channels include voltage-sensor domains (VSDs), their conductance is thought to be independent of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edd2aa8841baef734cd5b9ab18f296e
https://doaj.org/article/f2ae6a99fa0349efb26faf96d2b07a1a

Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion

Autor: Daniel E. Otzen, Yana Gofman, Jerzy Dorosz, Nir Ben-Tal, Niels Chr Nielsen, Sofiya Kolusheva, Raz Jelinek

Publikováno v: Dorosz, J, Gofman, Y, Kolusheva, S, Otzen, D, Ben-Tal, N, Nielsen, N C & Jelinek, R 2010, ' Membrane Interactions of Novicidin, a Novel Antimicrobial Peptide: Phosphatidylglycerol Promotes Bilayer Insertion ', The Journal of Physical Chemistry B, vol. 114, no. 34, pp. 11053-60 . https://doi.org/10.1021/jp1052248

Novicidin is an antimicrobial peptide derived from ovispirin, a cationic peptide which originated from the ovine cathelicidin SMAP-29. Novicidin, however, has been designed to minimize the cytotoxic properties of SMAP-29 and ovisipirin toward achievi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9715a64ae39f72c95f30d2304c2c3e56
https://pubmed.ncbi.nlm.nih.gov/20690652

Structural Aspects of the Interaction of Nk-2 Derived Peptides with Cancer Cells

Autor: Yana Gofman, Nir Ben-Tal, Regine Willumeit, Yasemin Manavbasi, Karl Lohner, Dagmar Zweytick

Publikováno v: ResearcherID

Antimicrobial peptides have gained interest as potential anti-cancer agents, e.g. inhibition of tumour growth in human prostate xenografts was shown by host defense like lytic peptides (1). We showed by Annexin V binding that, in prostate tumour cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b6a007312d66c1487c18dfaa70dd9a