Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Yana A. Sharapova"'
Autor:
Vladimir V. Voevodin, Ivan Timokhin, Yana A. Sharapova, Dmitry A. Suplatov, Nina Popova, Maksim V. Shegay, Vytas K. Švedas
Publikováno v:
The Journal of Supercomputing. 77:12382-12398
The field of biology is producing data faster than ever before. To approach its analysis efficiently, one can take advantage of a systematic symbiosis between the power of huge distributed-memory systems and the flexibility of locally managed shared-
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1302-1311 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Local 3D-structural differences in homologous proteins contribute to functional diversity observed in a superfamily, but so far received little attention as bioinformatic analysis was usually carried out at the level of amino
Local 3D-structural differences in homologous proteins contribute to functional diversity observed in a superfamily, but so far received little attention as bioinformatic analysis was usually carried out at the level of amino
Publikováno v:
Nucleic Acids Research
Zebra2 is a highly automated web-tool to search for subfamily-specific and conserved positions (i.e. the determinants of functional diversity as well as the key catalytic and structural residues) in protein superfamilies. The bioinformatic analysis i
Yosshi: a web-server for disulfide engineering by bioinformatic analysis of diverse protein families
Publikováno v:
Nucleic Acids Research
Disulfide bonds play a significant role in protein stability, function or regulation but are poorly conserved among evolutionarily related proteins. The Yosshi can help to understand the role of S–S bonds by comparing sequences and structures of ho
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:2049-2060
Doramapimod (BIRB-796) is widely recognized as one of the most potent and selective type II inhibitors of human p38α mitogen-activated protein kinase (MAPK); however, the understanding of its binding mechanism remains incomplete. Previous studies in
Publikováno v:
Methods in Molecular Biology ISBN: 9781071610350
Bioinformatic analysis of functionally diverse superfamilies can help to study the structure-function relationship in proteins, but represents a methodological challenge. The Mustguseal web-server can build large structure-guided sequence alignments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56175bc65a2b5f6c574b4ff144a5385f
https://doi.org/10.1007/978-1-0716-1036-7_12
https://doi.org/10.1007/978-1-0716-1036-7_12
Publikováno v:
The FEBS journalReferences. 288(10)
Neuraminidase A from Streptococcus pneumoniae (NanA) is a cell wall-bound modular enzyme containing one lectin and one catalytic domain. Unlike homologous NanB and NanC expressed by the same bacterium, the two domains within one NanA molecule do not
Publikováno v:
Journal of bioinformatics and computational biology. 18(6)
Conformational plasticity of the functionally important regions and binding sites in protein/enzyme structures is one of the key factors affecting their function and interaction with substrates/ligands. Molecular dynamics (MD) can address the challen
Publikováno v:
The FEBS Journal. 285:2428-2445
Neuraminidase A (NanA) of the pathogen Streptococcus pneumoniae cleaves receptors of the human respiratory epithelial surface during bacterial colonization. The full-size structure of NanA that contains one lectin and one catalytic domain within a si
Autor:
Maksim V. Shegay, Vytas K. Švedas, Dmitry A. Suplatov, Nina N. Popova, Yana A. Sharapova, Vladimir V. Voevodin, Kateryna Fesko
Publikováno v:
Communications in Computer and Information Science ISBN: 9783030365912
RuSCDays
RuSCDays
Construction of a multiple alignment of proteins that implement different functions within a common structural fold of a superfamily is a valuable tool in bioinformatics, but represents a challenge. The process can be seen as a pipeline of independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dc602ac63f3742e958173adc15ea4f9
https://doi.org/10.1007/978-3-030-36592-9_21
https://doi.org/10.1007/978-3-030-36592-9_21