ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation

Autor: Chia-Hsing Shen, Chih-Chang Chou, Ting-Yu Lai, Jer-En Hsu, You-Sheng Lin, Huai-Yu Liu, Yan-Kai Chen, I-Lin Ho, Pang-Hung Hsu, Tsung-Hsien Chuang, Chih-Yuan Lee, Li-Chung Hsu

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Activation of the epidermal growth factor receptor (EGFR) is crucial for development, tissue homeostasis, and immunity. Dysregulation of EGFR signaling is associated with numerous diseases. EGFR ubiquitination and endosomal trafficking are key events

Externí odkaz: https://doaj.org/article/46f74e63cf204abd90d444c7bc9535c0

Study on the effect of co-culture to the growth of Chlorella sp. and produce activity polysaccharide.

Autor: Yan-kai Chen, 陳彥凱

98
Chlorella sp. is a kind of microalgae with many nutrition. It has been produce in commercialize. In recent years, to enhance the biomass and the value of production is important objects. This thesis had studied in the interaction between Chlo

Externí odkaz: http://ndltd.ncl.edu.tw/handle/65923488117313371889

PyBindingCurve, Simulation, and Curve Fitting to Complex Binding Systems at Equilibrium

Autor: Steven Shave, Manfred Auer, Nhan T. Pham, Yan-Kai Chen

Publikováno v: Journal of Chemical Information and Modeling
Shave, S, Chen, Y-K, Pham, N T & Auer, M 2021, ' PyBindingCurve, simulation, and curve fitting to complex binding systems at equilibrium ', Journal of Chemical Information and Modeling . https://doi.org/10.1021/acs.jcim.1c00216

Understanding multicomponent binding interactions in protein-ligand, protein-protein and competition systems is essential for fundamental biology and drug discovery. Hand deriving equations quickly becomes unfeasible when the number of components is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b7dc4de50da6fa8e02267e76baa98b
http://europepmc.org/articles/PMC8243321

MRlogP: Transfer Learning Enables Accurate logP Prediction Using Small Experimental Training Datasets

Autor: Steven Shave, Manfred Auer, Yan-Kai Chen

Publikováno v: Processes
Volume 9
Issue 11
Processes, Vol 9, Iss 2029, p 2029 (2021)
Chen, Y-K, Shave, S & Auer, M 2021, ' MRlogP : Transfer learning enables accurate logP prediction using small experimental training datasets ', Processes, vol. 9, no. 11, 2029 . https://doi.org/10.3390/pr9112029

Small molecule lipophilicity is often included in generalized rules for medicinal chemistry. These rules aim to reduce time, effort, costs, and attrition rates in drug discovery, allowing the rejection or prioritization of compounds without the need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a60ed3cc894a622e292342bd94ffc9

Phase change memory modeling using Verilog-A

Autor: Yan-Kai Chen, Meng-Hsueh Chiang, Yi-Bo Liao

Publikováno v: 2007 IEEE International Behavioral Modeling and Simulation Workshop.

In this paper, we successfully develop a compact phase change memory (PCM) model using Verilog-A. As PCM has shown its potential for next generation memory device, a predictive, yet simple-to-use circuit model is crucial to the development. Since the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::535be0b670de3b62bfa13a09274025b1
https://doi.org/10.1109/bmas.2007.4437544