Zobrazeno 1 - 10
of 466
pro vyhledávání: '"Yan-Mei Li"'
Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
Autor:
Jinjian Hu, Wencheng Xia, Shuyi Zeng, Yeh-Jun Lim, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu, Yan-Mei Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been identified at multiple sites of
Externí odkaz:
https://doaj.org/article/d8ea981108d54492b64dcfa30bf8679b
Autor:
Dong-Min Liang, You-Jie Li, Jia-Xiang Zhang, Huan-Huan Shen, Chun-Xia Wu, Ning Xie, Yan Liang, Yan-Mei Li, Jiang-Nan Xue, Hong-Fang Sun, Qin Wang, Jian Yang, Xiao-Hua Li, Ping-Yu Wang, Shu-Yang Xie
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Blocking immune checkpoint CD47/SIRPα is a useful strategy to engineer macrophages for cancer immunotherapy. However, the roles of CD47-related noncoding RNA in regulating macrophage phagocytosis for lung cancer therapy remain unclear. This
Externí odkaz:
https://doaj.org/article/0495cd1b4f9048dbae488e0d37ac29ff
Autor:
Jing-Rui Song, Zhen-Peng Niu, Kun Yang, Li Wang, Yu-Bing Huang, Qing Rao, Hai-Yang Liu, Xiao-Jiang Hao, Yan-Mei Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117424- (2024)
Erythroleukemia, a subtype of acute myeloid leukemia (AML), is a life-threatening malignancy that affects the blood and bone marrow. Despite the availability of clinical treatments, the complex pathogenesis of the disease and the severe side effects
Externí odkaz:
https://doaj.org/article/5151d39298ff491ea128610c0334fef0
Autor:
Qin Liu, Zhen-Peng Niu, Kun Yang, Jing-Rui Song, Xue-Nai Wei, Yu-Bing Huang, Chun-Mao Yuan, Yan-Mei Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 115936- (2024)
Isogarcinol (ISO), a cytotoxic polycyclic polyprenylated acylphloroglucinol isolated from the edible fruits of Garcinia multiflora. However, synergistic combination of ISO and dexamethasone (DEX) to overcome leukemia glucocorticoid resistance has nev
Externí odkaz:
https://doaj.org/article/4e7b0d586d9844b88067a4c6aa1dbc89
Publikováno v:
Gynecological Endocrinology, Vol 39, Iss 1 (2023)
Background Polycystic ovary syndrome (PCOS) was known as the common endocrine disease in women, featured as hyperandrogenism, ovulation disorders, etc. Fat mass and obesity-associated protein (FTO), a m6A demethylase, is abnormal in the occurrence of
Externí odkaz:
https://doaj.org/article/d5737cfc70da4e178fde7fe880c5c3eb
Autor:
Yuan-Rong Liu, Dan-Dan Song, Dong-Min Liang, You-Jie Li, Yun-Fei Yan, Hong-Fang Sun, Mei-Ling Zhang, Jin-Xia Hu, Yu-Long Zhao, Yan Liang, Yan-Mei Li, Zhen Yang, Ran-Ran Wang, Hou-Feng Zheng, Pingyu Wang, Shu-Yang Xie
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 is considered as a “pseudokinase”, contributing to different kinds of cancer. However, the detaile
Externí odkaz:
https://doaj.org/article/d340353c87154691aa49e53355ddb7f8
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Intrinsic self-healing polymers attract increasing attention but often suffer from a narrow self-healing temperature range and unsatisfactory mechanical performance. Here, the authors use click chemistry to develop a library of catalyst-free reversib
Externí odkaz:
https://doaj.org/article/c80411124c2d4b7aa6a695b0f0c1b0b0
Publikováno v:
Frontiers in Psychology, Vol 14 (2023)
BackgroundUnderstanding the compliance of infected individuals and the psychological process underlying compliance during pandemics is important for preventing and controlling the spread of pathogens. Our study investigated whether fundamental social
Externí odkaz:
https://doaj.org/article/8189ea70bbfb47b69d67ed0cdfde35ee
Autor:
Yu-Bo Wei, Dong-Min Liang, Mei-Ling Zhang, You-Jie Li, Hong-Fang Sun, Qin Wang, Yan Liang, Yan-Mei Li, Ran-Ran Wang, Zhen-Lin Yang, Pingyu Wang, Shu-Yang Xie
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Long non-coding RNAs (lncRNAs) modulate cell proliferation, cycle, and apoptosis. However, the role of lncRNA-WFDC21P in the tumorigenesis of triple-negative breast cancer (TNBC) remains unclear. Results of this study demonstrated that WFDC21P levels
Externí odkaz:
https://doaj.org/article/1fd33487cb7f430bbc574bddb427a59b
Autor:
Ying-Ying Nie, Long-Jian Zhou, Yan-Mei Li, Wen-Cong Yang, Ya-Yue Liu, Zhi-You Yang, Xiao-Xiang Ma, Yong-Ping Zhang, Peng-Zhi Hong, Yi Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundOxidative stress, cholinergic deficiency, and neuroinflammation are hallmarks of most neurodegenerative disorders (NDs). Lipids play an important role in brain development and proper functioning. Marine-derived lipids have shown good memory
Externí odkaz:
https://doaj.org/article/5fe773213019414990252755444a919d