Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Yan Yi Wang"'
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in pa
Externí odkaz:
https://doaj.org/article/591c80fb4629487aa7be2ccc679b0658
Autor:
Wei-Wei Li, Xu-Xu Fan, Zi-Xiang Zhu, Xue-Jing Cao, Zhao-Yu Zhu, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011742 (2023)
Viral infection triggers the activation of transcription factor IRF3, and its activity is precisely regulated for robust antiviral immune response and effective pathogen clearance. However, how full activation of IRF3 is achieved has not been well de
Externí odkaz:
https://doaj.org/article/15d5fc0baacf4af2a01f4fdc4589db70
Autor:
Wei-Wei Luo, Zhen Tong, Pan Cao, Fu-Bing Wang, Ying Liu, Zhou-Qin Zheng, Su-Yun Wang, Shu Li, Yan-Yi Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor IRF8 has been shown to regulate monocyte differentiation via its DNA-binding activity. Here authors show that IRF8 is also involved in cytosolic DNA sensing via its phosphorylation-dependent association to the adaptor protein
Externí odkaz:
https://doaj.org/article/2f7cce334ca742d9bbb81e7290a22a5d
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found that the SARS-CoV-2 nucleocapsid pr
Externí odkaz:
https://doaj.org/article/632c797bc210429ea21d9b702364a008
Publikováno v:
Cell Insight, Vol 1, Iss 2, Pp 100014- (2022)
After herpes simplex virus type 1 (HSV-1) infection, the cytosolic sensor cyclic GMP-AMP synthase (cGAS) recognizes DNA and catalyzes synthesis of the second messenger 2′3′-cGAMP. cGAMP binds to the ER-localized adaptor protein MITA (also known a
Externí odkaz:
https://doaj.org/article/fcb8742a208d4c82becae0bdf1e0a522
Autor:
Jie-lin Tang, Qi Yang, Chong-hui Xu, He Zhao, Ya-ling Liu, Can-yu Liu, Yuan Zhou, Dong-wei Gai, Rong-juan Pei, Yun Wang, Xue Hu, Bo Zhong, Yan-yi Wang, Xin-wen Chen, Ji-zheng Chen
Publikováno v:
Protein & Cell, Vol 12, Iss 4, Pp 261-278 (2020)
Abstract TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered. We show
Externí odkaz:
https://doaj.org/article/65ca7654fa64403e8c01c160cfd956e6
Autor:
Meng-Qi Liu, Xing-Wen Zhang, Wen-Ping Fan, Shi-Lin He, Yan-Yi Wang, Zhi-Ye Chen, Ning-Ning Wang
Publikováno v:
Chinese Medical Journal, Vol 133, Iss 5, Pp 530-536 (2020)
Abstract. Background:. Texture features were the intrinsic properties of the human tissues and could efficiently detect the subtle functional changes of involved tissue. The pathologic changes of the lateral pterygoid muscle (LPM) were significantly
Externí odkaz:
https://doaj.org/article/97907ee433e94476a538728e7738468f
Autor:
Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi, Peng Zhou
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 386-389 (2020)
ABSTRACTIn December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molec
Externí odkaz:
https://doaj.org/article/f9fd26854b7c4bd4b2a427be77a1808e
Autor:
Yong Ran, Dan Li, Mei-Guang Xiong, Hua-Nan Liu, Tao Feng, Zheng-Wang Shi, Yu-Hui Li, Huang-Ning Wu, Su-Yun Wang, Hai-Xue Zheng, Yan-Yi Wang
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010270 (2022)
ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent remains enigmatic. In this study, we show that the ASFV genome contains AT-rich regions that a
Externí odkaz:
https://doaj.org/article/71cf65a7f51d4c229f77761f2a67e503
Publikováno v:
World Journal of Clinical Cases. 11:1106-1114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9912f0e467839d5b402fa277aba0e1
https://doi.org/10.12998/wjcc.v11.i5.1106
https://doi.org/10.12998/wjcc.v11.i5.1106