Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yan Yan-Neale"'
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
XLSX file - 243KB, This table summarizes all significant genetic features that differentiate sensitive versus insensitive cell lines for TNKSi/MEKi combination. The first sheet lists all cell lines for each group. The second sheet lists all genetic f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98357659919c6a16595e1f40b492fc17
https://doi.org/10.1158/0008-5472.22403508
https://doi.org/10.1158/0008-5472.22403508
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
PDF file - 68KB, Sensitivity of KRAS mutant cancer cells to TNKSi/MEKi combination. Synergistic cell lines are in red (cut-off of synergy score of 2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120c66d80736a8add956ce74f2e65cef
https://doi.org/10.1158/0008-5472.22403499
https://doi.org/10.1158/0008-5472.22403499
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
PDF file - 660KB, Supplementary Figure S1. All RAS mutant cell lines have a higher sensitivity to the TNKSi/MEKi combination. Supplementary Figure S2. Validation of TNKSi/MEKi combination in KRAS mutant cancer cells. Supplementary Figure S3. Combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c1ed739870295e826b9ca06823f4d0
https://doi.org/10.1158/0008-5472.22403517
https://doi.org/10.1158/0008-5472.22403517
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
PDF file - 123KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6336a2bcc1da4dd884ed5a8e2e5bc15e
https://doi.org/10.1158/0008-5472.22403514.v1
https://doi.org/10.1158/0008-5472.22403514.v1
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
XLSX file - 234KB, This table shows the features of all 138 cancer cell lines tested for the TNKSi/MEKi combination in the unbiased combination screen. Cell line name, lineage, RAS mutation status and synergy score for the TNKSi/MEKi combination are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db7d3ec112a125f2445b5deec1997a5
https://doi.org/10.1158/0008-5472.22403505
https://doi.org/10.1158/0008-5472.22403505
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
PDF file - 81KB, List of identified synergistic cell lines for TNKSi/MEKi combination in the large-scale combination screen and their KRAS status. KRAS mutants are in red.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0426140421e712ad5e07a2c175811e44
https://doi.org/10.1158/0008-5472.22403511.v1
https://doi.org/10.1158/0008-5472.22403511.v1
Autor:
Wenlin Shao, Nika N. Danial, William R. Sellers, Mark D. Stump, Jebediah Ledell, Janine Steiger, Vesselina G. Cooke, Brandon Antonakos, Michael D. Jones, Daisy Flemming, Joshua M. Korn, Dmitriy Sonkin, Yuji Mishina, Yan Yan-Neale, Joseph Lehár, Kristen E. Hurov, Marie Schoumacher
PDF file - 54KB, Chemical inhibitors used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11140634b75740d3e8b5e2937cdb67b
https://doi.org/10.1158/0008-5472.22403502.v1
https://doi.org/10.1158/0008-5472.22403502.v1
Autor:
Yaping Wang, Xin Chen, Zhuoliang Chen, John William Giraldes, Kirk Wright, Sean Kim, José S. Duca, Eric J. Martin, J. Tres Brazell, Kristen Hurov, Elizabeth R. Sprague, Yun Feng, David E. Puleo, Subarna Shakya, Yanqiu Yuan, David Sage, Matthew J. Meyer, Yuji Mishina, Yan Yan-Neale, Christopher Sean Straub, Li Tian, Simon Mathieu, Dongshu Chen, Wenlin Shao, B. Barry Touré, Troy Smith
Publikováno v:
Journal of Medicinal Chemistry. 59:4711-4723
MELK kinase has been implicated in playing an important role in tumorigenesis. Our previous studies suggested that MELK is involved in the regulation of cell cycle and its genetic depletion leads to growth inhibition in a subset of high MELK-expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef8110b976db9c7b26d95564840f324
https://doi.org/10.1021/acs.jmedchem.6b00052
https://doi.org/10.1021/acs.jmedchem.6b00052
Autor:
D. Randal Kipp, Craig Mickanin, Jeffery A. Porter, Albert Lai, Bing Zheng, Mark Stump, Yan Yan-Neale, John A. Tallarico, Young Shin Cho, Gregory R. Hoffman, Tobias Schmelzle, William R. Sellers, Samuel B. Ho, E. Robert McDonald, Kavitha Venkatesan, Yue Liu, Songping Zhao, Rosalie deBeaumont, Eric Billy, Ying Lin, Francesco Hofmann, Konstantinos J. Mavrakis, Vladimir Capka, Jianjun Yu, Antoine deWeck, Joshua T. McNamara, Emma Lees, Michael R. Schlabach, Hui Gao, Elizabeth R. Sprague, Nicholas Keen, Kristen Hurov, Kenneth Crawford, David A. Ruddy, David N. Ciccone, Guizhi Yang, Fallon Lin, Gregg McAllister, Justin Gu, Raymond Pagliarini, Alberto C. Vitari, Frank Stegmeier, Yingzi Yue, Hong Yin
Publikováno v:
Science. 351:1208-1213
Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f90e55c3fe4c3ecfba28cea037cdc9ce
https://doi.org/10.1126/science.aad5944
https://doi.org/10.1126/science.aad5944
Autor:
Shaowen Wang, Alan1, Yan Yan-Neale, Alan1, Fischer, Denise1, Zeremski, Marija1, Cai, Richard1, Jian Zhu1, Asselbergs, Fred1, Hampton, Garret2, Cohen, Dalia1 dalia.cohen@pharma.novartis.com
Publikováno v:
Oncogene. 9/18/2003, Vol. 22 Issue 40, p6204-6213. 10p. 1 Color Photograph, 1 Black and White Photograph, 6 Diagrams, 4 Graphs.