3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

Autor: Len F. Lee, Steven W. Kramer, A. W. Veenhuizen, Carol M. Koboldt, Paul W. Collins, Yan Y. Zhang, Peter C. Isakson, Karen Seibert, Thomas D. Penning

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2121-2124

A series of 3,4-diarylpyrazoles was synthesized and evaluated for their ability to selectively inhibit cyclooxygenase-2 (COX-2). A number of potent and selective inhibitors were identified and found to have oral anti-inflammatory activity in a rat ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::479d32fe6815640e8bcff985c1ac75d3
https://doi.org/10.1016/s0960-894x(97)00372-7

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)

Autor: Karen Seibert, AndersonGD, John J. Talley, Susan A. Gregory, Matthew J. Graneto, Yan Y. Zhang, James W. Malecha, Len F. Lee, Stella S. Yu, Stephen H. Docter, Bertenshaw, P. C. Isakson, P. W. Collins, E. G. Burton, J. N. Cogburn, Jeffery S. Carter, A. W. Veenhuizen, Carol M. Koboldt, T. D. Penning, Julie M. Miyashiro, D. J. Rogier, W E Perkins, Roland S. Rogers

Publikováno v: Journal of medicinal chemistry. 40(9)

A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb0795084059f20068b91d6f051cfb
https://pubmed.ncbi.nlm.nih.gov/9135032

Exploring the response and prediction of phytoplankton to environmental factors in eutrophic marine areas using interpretable machine learning methods.

Autor: Yang S; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address: yangshimin@ouc.edu.cn., Ma Y; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address: mayuanting@stu.ouc.edu.cn., Gao J; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China., Wang X; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China., Weng F; National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen 361005, China; Data Mining Research Center, Xiamen University, Xiamen 361005, China., Zhang Y; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China., Xu Y; MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address: xy8633@ouc.edu.cn.

Publikováno v: The Science of the total environment [Sci Total Environ] 2024 Nov 15; Vol. 951, pp. 175600. Date of Electronic Publication: 2024 Aug 17.

Structural impacts on the degradation behaviors of Ir-based electrocatalysts during water oxidation in acid.

Autor: Li M; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Qi J; National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230029, China., Zeng H; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Chen J; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Liu Z; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Gu L; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Wang J; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Zhang Y; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China., Wang M; Institute of Advanced Science Facilities, Shenzhen 518107, China., Zhang Y; Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China., Lu X; Faculty of Science and Technology, Technological and Higher Education Institute of Hong Kong, Hong Kong, China. Electronic address: xylu@thei.edu.hk., Yang C; School of Materials, Sun Yat-Sen University, Shenzhen 518107, China. Electronic address: yangchzh6@mail.sysu.edu.cn.

Publikováno v: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Nov 15; Vol. 674, pp. 108-117. Date of Electronic Publication: 2024 Jun 12.

Screening of metal-modified biochars for practical phosphorus recovery.

Autor: Li M; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China; Ecological-Environment & Health College (EEHC), Zhejiang A&F University, Hangzhou 311300, China., Xie Q; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China; Ecological-Environment & Health College (EEHC), Zhejiang A&F University, Hangzhou 311300, China., Xu F; Zhejiang Taizhou Ecological and Environmental Monitoring Center, Taizhou 318000, China., Zhang Y; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China; Ecological-Environment & Health College (EEHC), Zhejiang A&F University, Hangzhou 311300, China., Zhuang Z; Department of Chemistry, Tsinghua University, Beijing 100084, China., Xu J; Jiangsu Key Laboratory of Numerical Simulation of Large Scale Complex Systems and School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China., Xiang H; Ecological-Environment & Health College (EEHC), Zhejiang A&F University, Hangzhou 311300, China., Li Y; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China., Cai Y; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China., Chen Z; Fujian Key Laboratory of Pollution Control and Resource Reuse, School of Environmental and Resource Sciences, Fujian Normal University, Fuzhou 350007, Fujian Province, China. Electronic address: zlchen@fjnu.edu.cn., Yu B; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China; Ecological-Environment & Health College (EEHC), Zhejiang A&F University, Hangzhou 311300, China. Electronic address: bing.yu@zafu.edu.cn.

Publikováno v: The Science of the total environment [Sci Total Environ] 2024 Nov 07; Vol. 956, pp. 177342. Date of Electronic Publication: 2024 Nov 07.