Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Yan Y. Sanders"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Activation of the NLRP3 inflammasome is a two-step process: the priming and the activating. The priming step involves the induction of NLRP3 and pro-IL-1β, while the activating step leads to the full inflammasome activation triggered by a N
Externí odkaz:
https://doaj.org/article/43e681b4f7614926973282c498f28878
Autor:
Jieting Peng, Xun Xiao, Shizhen Li, Xing Lyu, Hui Gong, Shengyu Tan, Lini Dong, Yan Y. Sanders, Xiangyu Zhang
Publikováno v:
Experimental Gerontology, Vol 172, Iss , Pp 112085- (2023)
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible lung disease with limited therapeutic options. Aspirin can alleviate liver, kidney, and cardiac fibrosis. However, its role in lung fibrosis is unclear. This study aims to investigate
Externí odkaz:
https://doaj.org/article/e1a9816409274617ab9932d376afb073
Autor:
Zheyi Xiang, Le Bai, Jennifer Q. Zhou, Ricardo R. Cevallos, Jonathan R. Sanders, Gang Liu, Karen Bernard, Yan Y. Sanders
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101655- (2023)
Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up
Externí odkaz:
https://doaj.org/article/dd95ae331d94429bab83a46d0b50dd73
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19605-19617 (2013)
Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by chronic inflammation and excessive collagen accumulation in the lung. Myofibroblasts are the primary collagen-producing cells in pulmonary fibrosis. Histone deacetylase inhibito
Externí odkaz:
https://doaj.org/article/1bc2cb7724c0451f94b9bf80c242ac18
Autor:
Yan Y. Sanders, Hui Liu, Xiangyu Zhang, Louise Hecker, Karen Bernard, Leena Desai, Gang Liu, Victor J. Thannickal
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 8-16 (2013)
Aging and age-related diseases are associated with cellular senescence that results in variable apoptosis susceptibility to oxidative stress. Although fibroblast senescence has been associated with apoptosis resistance, mechanisms for this have not b
Externí odkaz:
https://doaj.org/article/8888b4462afa4cc98e5aef9431db2ca4
Publikováno v:
Expert Rev Respir Med
INTRODUCTION: Pulmonary fibrosis is an age-related, progressive, and fatal disease with a median survival of 3–5 years after diagnosis; idiopathic pulmonary fibrosis (IPF) is the most common type. It is characterized by fibroblast proliferation and
Autor:
Huachun Cui, Na Xie, Sami Banerjee, Tapan Dey, Rui-Ming Liu, Veena B. Antony, Yan Y. Sanders, Taylor S. Adams, Jose L. Gomez, Victor J. Thannickal, Naftali Kaminski, Gang Liu
Publikováno v:
American journal of respiratory and critical care medicine. 206(4)
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:471-472
Autor:
Sunad Rangarajan, Victor J. Thannickal, Naomi J. Logsdon, Samuel R. Smith, Ashish Kurundkar, Deepali Kurundkar, Jessy S. Deshane, Jaroslaw W. Zmijewski, Yan Y. Sanders, K.G. Dsouza, Mohammad Rehan, Karen Bernard, Diptiman Chanda
Publikováno v:
Nature aging
Aging is a risk factor for progressive fibrotic disorders involving diverse organ systems, including the lung. Idiopathic pulmonary fibrosis, an age-associated degenerative lung disorder, is characterized by persistence of apoptosis-resistant myofibr
Autor:
Zheyi Xiang, Denise Stanford, Sandeep Bodduluri, Victor J. Thannickal, Q Jennifer Zhou, Xing Lyv, Steven M. Rowe, Yan Y. Sanders
Publikováno v:
JCI Insight
Tissue regeneration capacity declines with aging in association with heightened oxidative stress. Expression of the oxidant-generating enzyme, NADPH oxidase 4 (Nox4), is elevated in aged mice with diminished capacity for fibrosis resolution. Bromodom