Gene-environment interaction in molar-incisor hypomineralization.

Autor: Mariana Bezamat, Juliana F Souza, Fernanda M F Silva, Emilly G Corrêa, Aluhe L Fatturi, João A Brancher, Flávia M Carvalho, Tayla Cavallari, Laís Bertolazo, Cleber Machado-Souza, Mine Koruyucu, Merve Bayram, Andrea Racic, Benjamin M Harrison, Yan Y Sweat, Ariadne Letra, Deborah Studen-Pavlovich, Figen Seymen, Brad Amendt, Renata I Werneck, Marcelo C Costa, Adriana Modesto, Alexandre R Vieira

Publikováno v: PLoS ONE, Vol 16, Iss 1, p e0241898 (2021)

Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually o

Externí odkaz: https://doaj.org/article/69922acafe854f72af7643e9aa53ec9d

Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin α-helical bundle

Autor: Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Léa Jean-François, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith

Publikováno v: Proceedings of the National Academy of Sciences. 119

Occludin is a tetramembrane-spanning tight junction protein. The long C-terminal cytoplasmic domain, which represents nearly half of occludin sequence, includes a distal bundle of three α-helices that mediates interactions with other tight junction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c85f2830f2c4ce38511422dcb6f2b11
https://doi.org/10.1073/pnas.2204618119

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease

Autor: Li Zuo, Wei-Ting Kuo, Feng Cao, Sandra D Chanez-Paredes, Daniel Zeve, Prabhath Mannam, Léa Jean-François, Anne Day, W Vallen Graham, Yan Y Sweat, Nitesh Shashikanth, David T Breault, Jerrold R Turner

Publikováno v: Gut.

ObjectiveIntestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases intestinal paracellular permeability and correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7e505c93274e5944ff6bea2fa286e1
https://pubmed.ncbi.nlm.nih.gov/35537812

Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism.

Autor: Eliason S; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA.; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, Iowa, USA., Hong L; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, Iowa, USA.; Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, Iowa, USA., Sweat Y; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA.; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, Iowa, USA., Chalkley C; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA.; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, Iowa, USA., Cao H; Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, Iowa, USA., Liu Q; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA., Qi H; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA., Xu H; Department of Internal Medicine, University of Arkansas for Medical Science, Little Rock, Arkansas, USA., Zhan F; Department of Internal Medicine, University of Arkansas for Medical Science, Little Rock, Arkansas, USA., Amendt BA; Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa, USA.; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, Iowa, USA.; Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, Iowa, USA.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Sep; Vol. 12 (9), pp. e1037.

The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche.

Autor: Sweat M; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; The Craniofacial Anomalies Research Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Sweat Y; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; The Craniofacial Anomalies Research Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Yu W; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Su D; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; The Craniofacial Anomalies Research Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Leonard RJ; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Eliason SL; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; The Craniofacial Anomalies Research Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA., Amendt BA; Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; The Craniofacial Anomalies Research Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.; Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa, USA.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2021 Jun; Vol. 39 (6), pp. 761-775. Date of Electronic Publication: 2021 Feb 13.