Výsledky vyhledávání - "Yan Xing Jia"

A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis

Autor: Shan-Mei, Chen, Jun-Nan, Feng, Chuan-Ke, Zhao, Li-Cheng, Yao, Li-Xin, Wang, Lin, Meng, Shao-Qing, Cai, Cai-Yun, Liu, Li-Ke, Qu, Yan-Xing, Jia, Cheng-Chao, Shou

Publikováno v: American journal of cancer research. 12(11)

Cancer is one of the main causes of death in humans worldwide, the development of more effective anticancer drugs that can inhibit the malignant progression of cancer cells is of great significance. Aiphanol is a natural product identified from the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::786aca85074c696410891636c7e25052
https://pubmed.ncbi.nlm.nih.gov/36504899

Zobrazit plný text záznamu

Aiphanol, a multi-targeting stilbenolignan, potently suppresses mouse lymphangiogenesis and lymphatic metastasis

Autor: Shan-mei Chen, Chuan-ke Zhao, Li-cheng Yao, Li-xin Wang, Yu-nan Ma, Lin Meng, Shao-qing Cai, Cai-yun Liu, Li-ke Qu, Yan-xing Jia, Cheng-chao Shou

Publikováno v: Acta pharmacologica Sinica.

The high incidence of lymphatic metastasis is closely related to poor prognosis and mortality in cancers. Potent inhibitors to prevent pathological lymphangiogenesis and lymphatic spread are urgently needed. The VEGF-C-VEGFR3 pathway plays a vital ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f316adeed0630d1b92066ed8714632
https://pubmed.ncbi.nlm.nih.gov/35778489

Zobrazit plný text záznamu

Synthetic studies of the HIV-1 protease inhibitive didemnaketals: stereocontrolled synthesis of an ester side chain

Autor: Xue Zhi Zhao, Lei Peng, Xue Qiang Li, Yong-Qiang Tu, Yan Xing Jia

Publikováno v: Tetrahedron Letters. 45:3713-3716

The stereocontrolled synthesis of the C1–C8 portion, the ester side chain of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through 15 steps starting from (S)-carvone as the chiral template. This ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e0a1d1719fafdfb5fb4039104d17b0
https://doi.org/10.1016/j.tetlet.2004.03.103

Zobrazit plný text záznamu

An Interesting AlEt3-PromotedStereoselective Tandem Rearrangement/Reductionof α-Hydroxy (or Amino) Heterocyclopropane

Autor: De Run Li, Yan Xing Jia, Bin Wu, Xue Zhi Zhao, Yong-Qiang Tu, Xin Li

Publikováno v: Synlett. :0623-0626

s: THF-inactivated AlEt 3 has been found to have an interesting double reactivity: Lewis acidity and reduction activity, which can result in a novel tandem rearrangement/reduction of α-hydroxy (or amino) heterocyclopropane. On the basis of this obse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::688fb54d24ec3709a0aa6dee7ef44e50
https://doi.org/10.1055/s-2003-38376

Zobrazit plný text záznamu

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

Autor: Yong-Qiang Tu, Xin Li, Yan Xing Jia, Xue Zhi Zhao, Bin Wu

Publikováno v: Tetrahedron. 58:1697-1708

The stereoselective synthesis of the spiroketal fragment 4a and its C1″-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective constr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::691e4086210c2bd2d2cf15eb5a260e03
https://doi.org/10.1016/s0040-4020(02)00059-5

Zobrazit plný text záznamu

Diastereo-recognizable reaction between Cr(VI) reagents and tertiary α-hydroxy epoxide

Autor: Bao Min Wang, Shi Kuo Ren, Michael C. K. Choi, Yan Xing Jia, Albert S. C. Chan, Yong-Qiang Tu

Publikováno v: Tetrahedron Letters. 42:2141-2144

Chromium(VI) reagents containing pyridine derivatives were found to be able to oxidize diastereo-recognizably tertiary α-hydroxy epoxides to form carbonyl compounds. The correlation of structure–selectivity of this reaction was discussed, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50682efac77b1b0ae4debbe989a24b48
https://doi.org/10.1016/s0040-4039(01)00009-0

Zobrazit plný text záznamu

Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Stereocontrolled Synthetic Approach to the Key Mother Spiroketals

Autor: Shi Kuo Ren, Xin Li, William Kitching, Albert S. C. Chan, Yan Xing Jia, Yong-Qiang Tu, Bin Wu

Publikováno v: Organic Letters. 3:847-849

[GRAPHICS] The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1'R,1"R)-2(acetylhydroxymethyl)-4, 10-dimethyl-8(isopropenylhydroxymethyl)-1, 7-dioxaspiro[5,5]-undecane (4a) and its C1"-epimer (4b), the key mother spiroketals of the HIV-1 protease inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0b9d4b589b22a7dfcafd49481406da
https://doi.org/10.1021/ol007016e

Zobrazit plný text záznamu