Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Yan T Lee"'
Autor:
Dmitry V. Vasilyev, Scott Christian Mayer, Qin J. Shan, John Dunlop, Yan T. Lee, Mark R. Bowlby
Publikováno v:
European Journal of Pharmacology. 581:97-104
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the pacemaker currents in neurons (I(h)) and cardiac (I(f)) cells. As such, the identification and characterization of novel blockers of HCN channels is important to enable t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4046be81b4cc5a530edc2a7fb0c7c9fe
https://doi.org/10.1016/j.ejphar.2007.11.058
https://doi.org/10.1016/j.ejphar.2007.11.058
Publikováno v:
British Journal of Pharmacology. 145:894-906
Benzodiazepines (BZDs) have been used extensively for more than 40 years because of their high therapeutic index and low toxicity. Although BZDs are understood to act primarily as allosteric modulators of GABA(A) receptors, the mechanism of modulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e918ef44b9fdf5297326fff4f4afd3
https://doi.org/10.1038/sj.bjp.0706251
https://doi.org/10.1038/sj.bjp.0706251
Autor:
Yan T. Lee, Qiang Wang
Publikováno v:
European Journal of Pharmacology. 378:349-356
Using the standard patch clamp whole cell recording method, we assessed the pharmacological activity of four fenamate nonsteroidal anti-inflammatory drugs, meclofenamic acid, flufenamic acid, mefenamic acid and niflumic acid, on hKv2.1, a major human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291cbb538de500e47390efcb22a576fa
https://doi.org/10.1016/s0014-2999(99)00485-9
https://doi.org/10.1016/s0014-2999(99)00485-9
Publikováno v:
Biophysical Journal. 100(3)
Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Avenue Cambridge, MA 02139, USA.QPatch HTX is an automated patch clamp system with greatly increased throughput over conventional patch clamp methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8137baa5c4a9d1e5bd94773612ddf8c
Autor:
Yan T. Lee, John Dunlop, Scott Christian Mayer, Veronica Soloveva, Stanley P. Nawoschik, Edward J. Kaftan, Dmitry V. Vasilyev, Mark R. Bowlby, Qin J. Shan
Publikováno v:
Journal of biomolecular screening. 14(9)
Hyperpolarization-activated cation nonselective (HCN) channels represent an interesting group of targets for drug development. In this study, the authors report the development of a novel membrane potential-sensitive dye (MPSD) assay for HCN channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065bc3e9927f8d4dd48cd971dab38c4e
https://pubmed.ncbi.nlm.nih.gov/19773585
https://pubmed.ncbi.nlm.nih.gov/19773585
Publikováno v:
Brain research. Molecular brain research. 115(1)
The primary goal of this study was to use the cloned neuronal Kv channels to test if pimozide (PMZD), an antipsychotic drug, modulates the activity of Kv channels. In CHO cells, PMZD blocked Kv2.1, a major neuronal delayed rectifier, in a manner that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985f0e4a442a7be37b6539cc4aa65607
https://pubmed.ncbi.nlm.nih.gov/12824052
https://pubmed.ncbi.nlm.nih.gov/12824052
Publikováno v:
Biophysical Journal. (3):324a
In the past decade, technological advancements have enabled automation of patch clamp recordings. Instruments like the Ionworks Quattro produces electrophysiological data from a 384 well plate in about an hour. However, they also require proprietary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1354b52dd7e7340d6d34190a9c29ec