Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yan Suveyzdis"'
Publikováno v:
Journal of Biological Chemistry. 287:23923-23931
MsbA is an essential Escherichia coli ATP-binding cassette (ABC) transporter involved in the flipping of lipid A across the cytoplasmic membrane. It is a close homologue of human P-glycoprotein involved in multidrug resistance, and it similarly accep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e2cfb578896b983988fd410922fed1
https://doi.org/10.1074/jbc.m112.359208
https://doi.org/10.1074/jbc.m112.359208
Publikováno v:
Applied Spectroscopy. 64:967-972
Time-resolved Fourier transform infrared (FT-IR) spectroscopy can reveal molecular details of protein interactions. Analysis of difference spectra selects the absorptions of respective protein groups involved in an interaction against the background
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8cbdf7faeab9edd85f352963b104bb
https://doi.org/10.1366/000370210792434341
https://doi.org/10.1366/000370210792434341
Autor:
Alfred Wittinghofer, Carsten Kötting, Klaus Gerwert, Begoña Sot, Delia Deaconescu, Yan Suveyzdis
Publikováno v:
The EMBO Journal. 29:1205-1214
The molecular mechanism by which dual-specificity RasGAPs of the Gap1 subfamily activate the GTP hydrolysis of both Rap and Ras is an unresolved phenomenon. RasGAPs and RapGAPs use different strategies to stimulate the GTPase reaction of their cognat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548e4f4e6952bde0770045c534595218
https://doi.org/10.1038/emboj.2010.20
https://doi.org/10.1038/emboj.2010.20
Publikováno v:
Proceedings of the National Academy of Sciences. 105:6260-6265
Members of the Ras superfamily of small G proteins play key roles in signal transduction pathways, which they control by GTP hydrolysis. They are regulated by GTPase activating proteins (GAPs). Mutations that prevent hydrolysis cause severe diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f86d537554eee227f5475eeeffa8e9
https://doi.org/10.1073/pnas.0712095105
https://doi.org/10.1073/pnas.0712095105
Autor:
Marco Blessenohl, Alfred Wittinghofer, Yan Suveyzdis, Klaus Gerwert, Carsten Kötting, Roger S. Goody
Publikováno v:
Proceedings of the National Academy of Sciences. 103:13911-13916
The hydrolysis of nucleoside triphosphates by enzymes is used as a regulation mechanism in key biological processes. Here, the GTP hydrolysis of the protein complex of Ras with its GTPase-activating protein is monitored at atomic resolution in a nonc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85f41776e95ca3cd1af08f3b3cb2796
https://doi.org/10.1073/pnas.0604128103
https://doi.org/10.1073/pnas.0604128103
Publikováno v:
Chembiochem : a European journal of chemical biology. 8(7)
Ras, the prototype of the Ras superfamily, acts as a molecular switch for cell growth. External growth signals induce a GDP-to-GTP exchange. This modifies the Ras surface (Ras(on)GTP) and enables effector binding, which then activates signal-transduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb97266b06cb6b3cea4f4837ffa82b5a
https://pubmed.ncbi.nlm.nih.gov/17385754
https://pubmed.ncbi.nlm.nih.gov/17385754
Autor:
Oliver Daumke, Alfred Wittinghofer, Klaus Gerwert, Carsten Kötting, Yan Suveyzdis, Partha Pratim Chakrabarti
Publikováno v:
Journal of molecular biology. 367(4)
Rap1 and Rap2 are the only small guanine nucleotide-binding proteins of the Ras superfamily that do not use glutamine for GTP hydrolysis. Moreover, Rap1GAP, which stimulates the GTPase reaction of Rap1 10(5)-fold, does not have the classical "arginin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa67277311a278017abe6f8298e8520e
https://pubmed.ncbi.nlm.nih.gov/17300802
https://pubmed.ncbi.nlm.nih.gov/17300802
Autor:
Angela Kallenbach, Yan Suveyzdis, Klaus Gerwert, Marco Blessenohl, Sven Brucker, Carsten Ktting, Partha Chakrabarti, Katrin Beckmann, Carolin Eichholz
Publikováno v:
GBM Annual Fall meeting M�nster 2004. 2004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9af4a21f231d04e08f2c66da936baab
https://doi.org/10.1240/sav_gbm_2004_h_000710
https://doi.org/10.1240/sav_gbm_2004_h_000710
Publikováno v:
GBM Annual Fall meeting M�nster 2004. 2004
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623036b39a84e6b688a64b47e00cd25d
https://doi.org/10.1240/sav_gbm_2004_h_000769
https://doi.org/10.1240/sav_gbm_2004_h_000769
Publikováno v:
The Journal of biological chemistry. 279(44)
GTPase activating proteins (GAPs) down-regulate Ras-like proteins by stimulating their GTP hydrolysis, and a malfunction of this reaction leads to disease formation. In most cases, the molecular mechanism of activation involves stabilization of a cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ff5586a60ee128fb4032836fa56eee
https://pubmed.ncbi.nlm.nih.gov/15292263
https://pubmed.ncbi.nlm.nih.gov/15292263