Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yan Shan Leong"'
Autor:
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase
Externí odkaz:
https://doaj.org/article/8f3f3b68e6d74f248a8f293e7fa6c66a
Autor:
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus rep
Externí odkaz:
https://doaj.org/article/f164a1f335254aad9b2305f3200a7da5
Autor:
Ayesa Syenina, Esther S. Gan, Justin Z. N. Toh, Ruklanthi de Alwis, Lowell Z. Lin, Christine Y. L. Tham, Jia Xin Yee, Yan Shan Leong, Huizhen Sam, Charlene Cheong, Yii Ean Teh, Ian L. E. Wee, Dorothy H. L. Ng, Kuan Rong Chan, Jean X. Y. Sim, Shirin Kalimuddin, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectiveness. However
Externí odkaz:
https://doaj.org/article/ecfcaa6f536c4157ba77ecce6b10848c
Autor:
Roland Tschismarov, Raphaël M. Zellweger, Min Jie Koh, Yan Shan Leong, Jenny G. Low, Eng Eong Ooi, Christian W. Mandl, Katrin Ramsauer, Ruklanthi de Alwis
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Chikungunya is a mosquito-borne disease that causes periodic but explosive epidemics of acute disease throughout the tropical world. Vaccine development against chikungunya virus (CHIKV) has been hampered by an inability to conduct efficacy trials du
Externí odkaz:
https://doaj.org/article/af56162da81644c2bd6b091d01c0e266
Autor:
Patrick Tan, John Connolly, Jeeyun Lee, Dennis Kappei, Bin Tean Teh, Steven G. Rozen, Wai Keong Wong, Kyoung-Mee Kim, Khee Chee Soo, Hock Soo Ong, Weng Hoong Chan, Pierce K.H. Chow, Wei Peng Yong, Khay Guan Yeoh, Sun Young Rha, Hassan Ashktorab, Duane Smoot, Apinya Jusakul, Alvin Ng, Cedric Chuan Young Ng, Erna Gondo Santoso, Angie Tan Lay Keng, Su Ting Tay, Minghui Lee, Xuewen Ong, Xiaosai Yao, Tannistha Nandi, Joyce Suling Lin, Wen Fong Ooi, Qianqao Tang, Ai Ping Lee Lim, Yan Shan Leong, Chang Xu, Shenli Zhang, Jeffrey Jun Ting Kwok, Nisha Padmanabhan, Manjie Xing, Aditi Qamra
Supplementary text S1. Supplementary Figure 1: Chromatin Profiles of Primary GC. Supplementary Figure 2: Epithelial features of GC promoters. Supplementary Figure 3: GC Somatic Promoter Features. Supplementary Figure 4: Association of Somatic Promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d4652fa03e02d6dd59bc7833bfe204
https://doi.org/10.1158/2159-8290.22531775
https://doi.org/10.1158/2159-8290.22531775
Autor:
Youjia Zhong, Kuan Rong Chan, Carina Tay, Zi Wei Chia, Hui’ En Li, Tanamas Siriphanitchakorn, Eugenia Ong, Yan Shan Leong, Alicia Kang, Regena Chua, Gaik Chin Yap, Chiung-Hui Huang, Joey Lim, Anthony Tan, Jenny Low, Lynette Shek, Elizabeth Tham, Eng Eong Ooi
For improved safety, children are vaccinated with a lower dose and extended interval for mRNA COVID-19 vaccines; however, whether there is protection before dose 2 is unknown. We recruited 113 children receiving BNT162b2 primary vaccination during an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::047accb081a9edd9eb9f42d0282d7c6b
https://doi.org/10.21203/rs.3.rs-2421432/v1
https://doi.org/10.21203/rs.3.rs-2421432/v1
Autor:
Scott C. Roberts, Hwee Cheng Tan, Sean M. Sullivan, Suezanne Parker, Daiki Matsuda, Kiyoshi Tachikawa, Rodrigo Yelin, Jerel Vega, Clement Yau, Shirin Kalimuddin, Kyoung-Joo Jenny Park, Wendy Taylor, Jenny G. Low, Ruklanthi de Alwis, Eng Eong Ooi, Hari Bhaskaran, Summer L. Zhang, Maher Alayyoubi, Yan Shan Leong, Priya Karmali, Shiwei Chen, Jared Davis, Brian M. Sullivan, Brenda Clemente, Jose A. Gonzalez, Marciano Sablad, Esther S. Gan, Elizabeth C. Allen, Paula Hartman, Steve G. Hughes, Bao Yanjie, Adrian Dukanovic, Pad Chivukula
Publikováno v:
Molecular Therapy. 29:1970-1983
A self-transcribing and replicating RNA (STARR)-based vaccine (LUNAR-COV19) has been developed to prevent SARS-CoV-2 infection. The vaccine encodes an alphavirus-based replicon and the SARS-CoV-2 full-length spike glycoprotein. Translation of the rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a82ddef5ba66908d9a13b3436eaa01
https://doi.org/10.1016/j.ymthe.2021.04.001
https://doi.org/10.1016/j.ymthe.2021.04.001
Autor:
Eng Eong Ooi, Eugenia Ong, Jia Xin Yee, Justin Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne Chan, Rose Sekulovich, Brian Sullivan, Kelly Lindert, Sean Sullivan, Pad Chivukula, Steve Hughes, Jenny Low, Kuan Rong Chan
Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. This vaccine platform has been extended to encode an alphavirus replicase that self-amplifies the full length mRNA and SARS-CoV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742101b404e01debc7c417a842e9d2fd
https://doi.org/10.21203/rs.3.rs-1629079/v1
https://doi.org/10.21203/rs.3.rs-1629079/v1
Autor:
Yvonne Fu Zi Chan, Eugenia Z. Ong, Yan Shan Leong, Kelly Lindert, Brian B Sullivan, Eng Eong Ooi, Ruklanthi de Alwis, Rose Sekulovich, Jia Xin Yee, Jenny G. Low, Shiwei Chen, Jean Siim, Summer L. Zhang, Shirin Kalimuddin, Pad Chivukula, Ayesa Syenina, Tania Mah, Hwee Cheng Tan, Sean M. Sullivan, Steven G Hughes, Natalene Yuen
BackgroundThe pandemic of coronavirus disease-19 (Covid-19) continues to afflict the lives and livelihoods of many as global demand for vaccine supply remains unmet.MethodsPhase 1 of this trial (N=42) assessed the safety, tolerability and immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00fc3b0dcf4a231ed451fc5c33ea2672
https://doi.org/10.1101/2021.07.01.21259831
https://doi.org/10.1101/2021.07.01.21259831
Autor:
Martin Qui, Ruklanthi de Alwis, Christine Y.L. Tham, Eng Eong Ooi, Nina Le Bert, Eugenia Z. Ong, Anthony T. Tan, Antonio Bertoletti, Joey M.E. Lim, Summer L. Zhang, Jia Xin Yee, Ayesa Syenina, Yan Shan Leong, Shirin Kalimuddin, Jean X.Y. Sim, Hwee Cheng Tan, Jenny G. Low
Publikováno v:
Med (New York, N.y.)
Background RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted of 2 doses, the onset of protection for both licensed RNA vaccines was observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeb411095ad9f4b74ace4e49e0f6114
http://europepmc.org/articles/PMC8030737
http://europepmc.org/articles/PMC8030737