Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Yan‑Yan Zhan"'
Autor:
Jihuan Hou, Kunrong Mei, Daxuan Wang, Sunkui Ke, Xiong Chen, Jin Shang, Guixia Li, Yan Gao, Huifang Xiong, Haoran Zhang, Lu Chen, Wenqing Zhang, Yabin Deng, Xiaoting Hong, Di-Ao Liu, Tianhui Hu, Wei Guo, Yan-yan Zhan
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114604- (2024)
Summary: Exo70, a key exocyst complex component, is crucial for cell motility and extracellular matrix (ECM) remodeling in cancer metastasis. Despite its potential as a drug target, Exo70’s post-translational modifications (PTMs) are poorly charact
Externí odkaz:
https://doaj.org/article/f89378c426564a37ba83a1499b2215e5
Autor:
Liyuan Mao, Yan-yan Zhan, Bin Wu, Qiang Yu, Liang Xu, Xiaoting Hong, Linhai Zhong, Panying Mi, Li Xiao, Xinquan Wang, Hanwei Cao, Wenqing Zhang, Binbin Chen, Jingzhou Xiang, Kunrong Mei, Ravi Radhakrishnan, Wei Guo, Tianhui Hu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Elevated expression of ULK1 is known to be inversely correlated with breast cancer metastasis. Here, the authors report Exo70 as a substrate of ULK1 that suppresses cancer metastasis, and show that ERK1/2 mediated phosphorylation of Exo70 leads to op
Externí odkaz:
https://doaj.org/article/7a8d91e583c5427ba8f9a268e2cf0b5b
Autor:
Dandan Li, Li Xiao, Yuetan Ge, Yu Fu, Wenqing Zhang, Hanwei Cao, Binbin Chen, Haibin Wang, Yan-yan Zhan, Tianhui Hu
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-6 (2018)
Abstract Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated during colon cancer progression, was
Externí odkaz:
https://doaj.org/article/7d1a53b12c5045cc8502e2f6b9662a61
Autor:
Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue. Matrine is an alkaloid extracted from the herb root of a traditional Chinese medicine
Externí odkaz:
https://doaj.org/article/ece995cda1a645419194407b80d39d78
Autor:
Li Xiao, Kaifeng Zheng, Xia Lv, Jihuan Hou, Liang Xu, Yujie Zhao, Fei Song, Yaqiong Fan, Hanwei Cao, Wenqing Zhang, Xiaoting Hong, Yan-yan Zhan, Tianhui Hu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to da
Externí odkaz:
https://doaj.org/article/6da550d0c62d4b198d039f062b907a59
Autor:
Qiao Wu, Hong-kui Zhang, Pei-qiang Huang, Wen-jin Su, Yue-mao Shen, Hang-zi Chen, Wei-jia Wang, Wen-jun Liu, Shao-hua Xiang, Juan Wang, Yuan Wang, Yan Chen, Yan-yan Zhan, Lian-ru Zhang, Hui-ni Zeng, Jing-jing Liu
Supplementary Materials and Methods from A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efd16aa681becb802e219e6f93103f0
https://doi.org/10.1158/0008-5472.22386515.v1
https://doi.org/10.1158/0008-5472.22386515.v1
Autor:
Qiao Wu, Hong-kui Zhang, Pei-qiang Huang, Wen-jin Su, Yue-mao Shen, Hang-zi Chen, Wei-jia Wang, Wen-jun Liu, Shao-hua Xiang, Juan Wang, Yuan Wang, Yan Chen, Yan-yan Zhan, Lian-ru Zhang, Hui-ni Zeng, Jing-jing Liu
Supplementary Figures 1-5 from A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a734c97adc8301443124ee902d56bd49
https://doi.org/10.1158/0008-5472.22386518
https://doi.org/10.1158/0008-5472.22386518
Autor:
Xin-Chen Li, Yan-Yan Zhang, Qi-Yu Zhang, Jing-Shu Liu, Jin-Jun Ran, Le-Fei Han, Xiao-Xi Zhang
Publikováno v:
Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-15 (2024)
Abstract Background Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden
Externí odkaz:
https://doaj.org/article/6b3a4d91ff8841dd9f8155cf2a86c70e
Autor:
Jinying Shen, Yujie Zhao, Linhai Zhong, Tianhui Hu, Xiong Chen, Xiaolin Xu, Daxuan Wang, Yan-yan Zhan, Xiaoting Hong, Hanwei Cao, Yitong Zhou, Jianben Wu, Ying Lin, Wenqing Zhang, Jihuan Hou
Publikováno v:
Cancer Research. 81:5904-5918
Invasive mucinous lung adenocarcinoma (IMA) is a subtype of lung adenocarcinoma with a strong invasive ability. IMA frequently carries "undruggable" KRAS mutations, highlighting the need for new molecular targets and therapies. Nuclear receptor HNF4
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 6, Pp 1138-1143 (2024)
With the advancement of retinal imaging, hyperreflective foci (HRF) on optical coherence tomography (OCT) images have gained significant attention as potential biological biomarkers for retinal neuroinflammation. However, these biomarkers, represente
Externí odkaz:
https://doaj.org/article/b038877483674c828a8d627ea4a467ee