Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yan‐Ni Shi"'
Autor:
Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C. Dorrestein, Helge B. Bode, Pavel A. Pevzner, Hosein Mohimani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications. Here,
Externí odkaz:
https://doaj.org/article/56701c0cd5c2408cb5012222fe11866d
Autor:
Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C. Dorrestein, Helge B. Bode, Pavel A. Pevzner, Hosein Mohimani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/9f001c0a855843f0a381eb501e137b7e
Autor:
Kenan A. J. Bozhüyük, Leonard Präve, Carsten Kegler, Sebastian Kaiser, Yan-Ni Shi, Wolfgang Kuttenlochner, Leonie Schenk, T. M. Mohiuddin, Michael Groll, Georg K. A. Hochberg, Helge B. Bode
Many clinically used drugs are derived from or inspired by bacterial natural products that often are biosynthesised via non-ribosomal peptide synthetases (NRPS), giant megasynthases that activate and join individual amino acids in an assembly line fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370c2b7733fadbf661a3aaac117a0b5c
https://doi.org/10.1101/2022.12.02.518901
https://doi.org/10.1101/2022.12.02.518901
Autor:
Yi‐Ming Shi, Jan J. Crames, Laura Czech, Kenan A. J. Bozhüyük, Yan‐Ni Shi, Merle Hirschmann, Stefanie Lamberth, Peter Claus, Nicole Paczia, Christian Rückert, Jörn Kalinowski, Gert Bange, Helge B. Bode
Publikováno v:
Angew Chem Int Ed Engl
Angew Chem Int Ed
Angew Chem Int Ed
Benzoxazolinate is a rare bis-heterocyclic moiety that interacts with proteins and DNA and confers extraordinary bioactivities on natural products, such as C-1027. However, the biosynthetic gene responsible for the key cyclization step of benzoxazoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2153ac05f1058eb653b781766675d0bf
https://doi.org/10.1002/anie.202206106
https://doi.org/10.1002/anie.202206106
Autor:
Yi-Ming Shi, Merle Hirschmann, Yan-Ni Shi, Shabbir Ahmed, Desalegne Abebew, Nicholas J. Tobias, Peter Grün, Jan J. Crames, Laura Pöschel, Wolfgang Kuttenlochner, Christian Richter, Jennifer Herrmann, Rolf Müller, Aunchalee Thanwisai, Sacha J. Pidot, Timothy P. Stinear, Michael Groll, Yonggyun Kim, Helge B. Bode
Publikováno v:
Nature Chemistry
Nat Chem
Nat Chem
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in mutualistic symbiosis with entomopathogenic nematodes generate natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ebd9cea9fd140424a73059eec83e36
Publikováno v:
Phytochemistry. 195
About 95% of fatal mushroom poisonings worldwide are caused by amatoxins and phallotoxins mostly produced by species of Amanita, Galerina, and Lepiota. The genus Lepiota is supposed to include a high number of species producing amatoxins. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89e8096d97cc74d14b1f01c7fa3637e
https://pubmed.ncbi.nlm.nih.gov/34965486
https://pubmed.ncbi.nlm.nih.gov/34965486
Autor:
Kenan A. J. Bozhueyuek, Annabell Linck, Yan-Ni Shi, Peter Grün, Andreas Tietze, Janik Kranz, Florian Fleischhacker, Sarah Nowak, Frank Wesche, Helge B. Bode
Publikováno v:
Nature Chemistry. 11:653-661
Non-ribosomal peptide synthetases (NRPSs) are giant enzyme machines that activate amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of the 20 proteinogenic amino acids, their efficient manipulation would enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601d5636f427c15906a28cc3d21d1f1c
https://doi.org/10.1038/s41557-019-0276-z
https://doi.org/10.1038/s41557-019-0276-z
Autor:
Julia Oh, Yan-Ni Shi, Pavel A. Pevzner, Hosein Mohimani, Helge B. Bode, Florian Grundmann, Alexey Gurevich, Changhui Guan, Morgan Panitchpakdi, Amina Bouslimani, Edna Bode, Andrés Mauricio Caraballo-Rodríguez, Bahar Behsaz, Deepa D. Acharya, Annabell Linck, Pieter C. Dorrestein
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Non-Ribosomal Peptides (NRPs) represent a biomedically important class of natural products that include a multitude of antibiotics and other clinically used drugs. NRPs are not directly encoded in the genome but are instead produced by metabolic path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dd970b465997bb9044645ce14f6402
https://escholarship.org/uc/item/8j5742vh
https://escholarship.org/uc/item/8j5742vh
Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains
Publikováno v:
ChemBioChem
Chembiochem
Chembiochem
Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be77e29d6083579bdbc921320c9efc3f
Autor:
Yi-Ming Shi, Helge B. Bode, Mohammad Alanjary, Christian Richter, Christian Griesinger, Anja Schüffler, Harald Schwalbe, Gina L. C. Grammbitter, Matthias Witt, Yan-Ni Shi, Sahithya Phani Babu Vemulapalli
Publikováno v:
bioRxiv
Biosynthetic gene clusters (BGC) involved in aryl polyene (APE) biosynthesis are supposed to represent the most widespread BGC in the bacterial world.[1–3] Still, only hydrolysis products[4–8] and not the full-length product(s) have been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e20360ee6e7612736d869f545e8c87