Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Yan‐Cheng Yu"'
Autor:
Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structur
Externí odkaz:
https://doaj.org/article/29262a2be1a6426fa1afb92378ccb3fb
Autor:
Shan-Liang Sun, Jia-Zhen Wu, Jing-Jing Wang, Hai Zhou, Chen-Qian Zhang, Zhen-Jiang Tong, Yi-Bo Wang, Jiu-Kai Sha, Qing-Xin Wang, Jia-Chuan Liu, Xin-Rui Zheng, Qing-Qing Li, Meng-Yuan Zhang, Jin Yang, Tian-Hua Wei, Zi-Xuan Wang, Yan-Cheng Yu, Ning Ding, Xue-Jiao Leng, Xin Xue, He-Min Li, Wei-Chen Dai, Xiao-Ying Yin, Ye Yang, Jin-Ao Duan, Nian-Guang Li, Zhi-Hao Shi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115905- (2023)
The therapeutic benefits of available FLT3 inhibitors for AML are limited by drug resistance, which is related to mutations, as well toxicity caused by off-target effects. In this study, we introduce a new small molecule FLT3 inhibitor called danatin
Externí odkaz:
https://doaj.org/article/b4a16bb41b1041b8acc5195b558148af
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Qing‐Xin Wang, Yi‐Bo Wang, Jiu‐Kai Sha, Hai Zhou, Jia‐Chuan Liu, Jia‐Zhen Wu, Zhen‐Jiang Tong, Jiao Cai, Zi‐Jun Chen, Chen‐Qian Zhang, Xin‐Rui Zheng, Jing‐Jing Wang, Xiao‐Long Wang, Xin Xue, Yan‐Cheng Yu, Ning Ding, Xue‐Jiao Leng, Wei‐Chen Dai, Shan‐Liang Sun, Liang Chang, Nian‐Guang Li, Zhi‐Hao Shi
Publikováno v:
Drug Development Research. 84:296-311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6899df1c68e1c20799636d9816200ece
https://doi.org/10.1002/ddr.22032
https://doi.org/10.1002/ddr.22032
Autor:
Qing-Xin Wang, Yu-Hao Cao, Li-Jin Yang, Yi-Yuan Ma, Nan Li, Shi-Han Wu, Lu Chen, Jia-Zhen Wu, Zhen-Jiang Tong, Xiao-Long Wang, Xin Xue, Ning Ding, Xue-Jiao Leng, Liang Chang, Wei-Chen Dai, Yan-Cheng Yu, Shan-Liang Sun, Ye Yang, Nian-Guang Li, Zhi-Hao Shi
Publikováno v:
Future Medicinal Chemistry. 15:57-71
Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3 inhibitors possessing high selectivity and potency is of necessity. Methods & results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2c6feedaad9225b8c2e4b4b234b20
https://doi.org/10.4155/fmc-2022-0231
https://doi.org/10.4155/fmc-2022-0231
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Zhi-Hao Shi, Nian-Guang Li, Shan-Liang Sun, Shi-Han Wu, Li-Jin Yang, Yi-Yuan Ma, Yu-Hao Cao, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Jiu-Kai Sha, Ning Ding, Qiao-Li Liang, Liang Chang, Xiao-Long Wang, Jin-Ao Duan, Yan-Cheng Yu, Wei-Chen Dai, Ke Xie, Xue-Jiao Leng, Xin Xue
Publikováno v:
Letters in Drug Design & Discovery. 20
Background: Acute myeloid leukemia (AML) is the most common type of blood cancer. Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. Overexpression of FLT3 was found in 70-100% of patients with acute myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9250921b9447897024d7ae8b81f00588
https://doi.org/10.2174/1570180820666230519140242
https://doi.org/10.2174/1570180820666230519140242
Autor:
Liang Chang, Qiao-Li Liang, Nian-Guang Li, Shan-Liang Sun, Xiao-Bin Dai, Shi-Han Wu, Ning Ding, Yi-Yuan Ma, Zhen-Jiang Tong, Jia-Zhen Wu, Yi-Bo Wang, Yan-Cheng Yu, Xue-Jiao Leng, Xin Xue, Jin-Guo Xu, Wei-Chen Dai, Ke Xie, Jing-Han Zhao, Yu-Qi Hong, Tian-Xi Lan, Tian-Yu Mu, Xiao-Long Wang
Publikováno v:
Letters in Drug Design & Discovery. 20
Background: Alzheimer’s disease (AD), a chronic neurodegenerative disorder predominantly occurs among the elderly, is the leading cause of dementia. The accumulation of β-amyloid (Aβ) is considered the main pathogenies of AD, and β-site APP-clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39196b9a437c00d50c0a0593f56125f8
https://doi.org/10.2174/1570180820666230223151850
https://doi.org/10.2174/1570180820666230223151850
Publikováno v:
Computers and Geotechnics. 159:105453
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460a0432e41573459cee25897e59019b
https://doi.org/10.1016/j.compgeo.2023.105453
https://doi.org/10.1016/j.compgeo.2023.105453
Publikováno v:
Acta Geotechnica. 17:303-317
Root pile is a new type of pile that improves the load carrying capacity by roots penetrating into soils. To carry out the nonlinear settlement analysis of such a root pile in multilayered soils, the hyperbolicity-based load transfer model is in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1c5cee9a0442b7167ddfbac3fce0e2a
https://doi.org/10.1007/s11440-021-01215-8
https://doi.org/10.1007/s11440-021-01215-8