Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yamila N Torres Cleuren"'
Autor:
Sagen Flowers, Rushali Kothari, Yamila N Torres Cleuren, Melissa R Alcorn, Chee Kiang Ewe, Geneva Alok, Samantha L Fiallo, Pradeep M Joshi, Joel H Rothman
Publikováno v:
eLife, Vol 12 (2023)
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell deat
Externí odkaz:
https://doaj.org/article/7f877f324fdd41a2bb6a617247e8af68
Autor:
Yamila N Torres Cleuren, Chee Kiang Ewe, Kyle C Chipman, Emily R Mears, Cricket G Wood, Coco Emma Alma Al-Alami, Melissa R Alcorn, Thomas L Turner, Pradeep M Joshi, Russell G Snell, Joel H Rothman
Publikováno v:
eLife, Vol 8 (2019)
Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. elegans endode
Externí odkaz:
https://doaj.org/article/ae1998556e3f4e91b5cbe8ea4e9c95dd
Autor:
Gemma B. Danks, Heloisa Galbiati, Martina Raasholm, Yamila N. Torres Cleuren, Eivind Valen, Pavla Navratilova, Eric M. Thompson
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic. Results We quantified translation g
Externí odkaz:
https://doaj.org/article/27146042cbff4bafa8ca24be9bc0320f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Developmental gene regulatory networks (GRNs) underpin metazoan embryogenesis and have undergone substantial modification to generate the tremendous variety of animal forms present on Earth today. The nematode Caenorhabditis elegans has been a centra
Externí odkaz:
https://doaj.org/article/194460b1540e40138532846467242da6
Autor:
Russell G. Snell, Yamila N. Torres Cleuren, Chee Kiang Ewe, Geneva Alok, Sagen E. Flowers, Joel H. Rothman
Publikováno v:
Proc Natl Acad Sci U S A
Gene regulatory networks (GRNs) that direct animal embryogenesis must respond to varying environmental and physiological conditions to ensure robust construction of organ systems. While GRNs are evolutionarily modified by natural genomic variation, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3ef18b4f235fb30296eaa0f4ada22d
https://doi.org/10.1073/pnas.1920343117
https://doi.org/10.1073/pnas.1920343117
Autor:
Melissa R. Alcorn, Rushali Kothari, Chee Kiang Ewe, Geneva Alok, Yamila N. Torres Cleuren, Pradeep M. Joshi, Sagen E. Flowers, Joel H. Rothman
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). “Purifying selection” mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a523db0510d696e3151b50892d04db1
https://doi.org/10.1101/2021.10.27.466108
https://doi.org/10.1101/2021.10.27.466108
Autor:
Håkon Tjeldnes, Eivind Valen, Yamila N. Torres Cleuren, Tessa G. Montague, Kornel Labun, Maximilian Krause
Publikováno v:
Nucleic Acids Research
The CRISPR–Cas system is a powerful genome editing tool that functions in a diverse array of organisms and cell types. The technology was initially developed to induce targeted mutations in DNA, but CRISPR–Cas has now been adapted to target nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a423ec3de5c39fa2f923ec4e4e5efd
http://europepmc.org/articles/PMC6602426
http://europepmc.org/articles/PMC6602426
Publikováno v:
Current Protocols in Bioinformatics
The design of optimal guide RNA (gRNA) sequences for CRISPR systems is challenged by the need to achieve highly efficient editing at the desired location (on-target editing) with minimal editing at unintended locations (off-target editing). Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67461ce5f5b962cca68bf8996eb6e95b
https://hdl.handle.net/11250/2976066
https://hdl.handle.net/11250/2976066
Autor:
Yamila N. Torres Cleuren, Håkon Tjeldnes, Senna Hiensch, Teshome Tilahun Bizuayehu, Aniekan Okon, Carlston Wagner, Eivind Valen, Adam Giess, Maximilian Krause
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 3, Pp-(2020)
Cell Reports, Vol 31, Iss 3, Pp-(2020)
Summary: Translation initiation is often attributed as the rate-determining step of eukaryotic protein synthesis and key to gene expression control. Despite this centrality, the series of steps involved in this process is poorly understood. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453b3ff5c7be6970efcf384211bd42c7
https://hdl.handle.net/11250/2729171
https://hdl.handle.net/11250/2729171
Autor:
Yamila N. Torres Cleuren, Chee Kiang Ewe, Joel H. Rothman, Geneva Alok, Sagen E. Flowers, Russell G. Snell
Gene regulatory networks (GRNs) that direct animal embryogenesis must respond to varying environmental and physiological conditions to ensure robust construction of organ systems. While GRNs are evolutionarily modified by natural genomic variation, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9054112a5bbc7e307dd904e01342cf
https://doi.org/10.1101/831099
https://doi.org/10.1101/831099