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Chemical Synthesis of Acetobacter pasteurianus Lipid A with a Unique Tetrasaccharide Backbone and Evaluation of Its Immunological Functions.

Autor: Yamaura H; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan.; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, 567-0085, Osaka, Japan., Shimoyama A; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan.; Center for Advanced Modalities and DDS, Osaka University, 1-1 Yamadaoka, 565-0871, Suita, Osaka, Japan.; Forefront Research Center for Fundamental Sciences, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan., Hosomi K; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, 567-0085, Osaka, Japan., Kabayama K; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan.; Forefront Research Center for Fundamental Sciences, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan., Kunisawa J; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, 567-0085, Osaka, Japan.; Forefront Research Center for Fundamental Sciences, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan., Fukase K; Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan.; Center for Advanced Modalities and DDS, Osaka University, 1-1 Yamadaoka, 565-0871, Suita, Osaka, Japan.; Forefront Research Center for Fundamental Sciences, Osaka University, 1-1 Machikaneyama, 560-0043, Toyonaka, Osaka, Japan.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jun 10; Vol. 63 (24), pp. e202402922. Date of Electronic Publication: 2024 Apr 29.

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Thoracic Aortic Plaque Burden and Prediction of Cardiovascular Events in Patients Undergoing 320-row Multidetector CT Coronary Angiography.

Autor: Otsuka K; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine.; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Ishikawa H; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Yamaura H; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Hojo K; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Kono Y; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Shimada K; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Kasayuki N; Department of Cardiovascular Medicine, Fujiikai Kashibaseiki Hospital., Fukuda D; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine.

Publikováno v: Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2024 Mar 01; Vol. 31 (3), pp. 273-287. Date of Electronic Publication: 2023 Sep 27.

Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue.

Autor: Sun X; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan., Hosomi K; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan., Shimoyama A; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.; Collaborative Research Between NIBIOHN and Graduate School of Science, Forefront Research Center, Osaka University, Osaka 560-0043, Japan., Yoshii K; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.; Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan., Saika A; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan., Yamaura H; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan., Nagatake T; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.; Department of Life Sciences, Laboratory of Functional Anatomy, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan., Kiyono H; Division of Gastroenterology, Department of Medicine, University of California San Diego (UCSD), San Diego, CA 92093, USA.; Chiba University (CU)-UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV), UCSD, San Diego, CA 92093-0063, USA.; Future Medicine Education and Research Organization, Chiba University, Chiba 260-8670, Japan.; Department of Human Mucosal Vaccinology, Chiba University Hospital, Chiba 260-8677, Japan., Fukase K; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.; Collaborative Research Between NIBIOHN and Graduate School of Science, Forefront Research Center, Osaka University, Osaka 560-0043, Japan., Kunisawa J; Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.; Department of Chemistry, Graduate School of Science, Osaka University, Osaka 560-0043, Japan.; Collaborative Research Between NIBIOHN and Graduate School of Science, Forefront Research Center, Osaka University, Osaka 560-0043, Japan.; Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.; Research Organization for Nano and Life Innovation, Waseda University, Tokyo 162-0041, Japan.; Graduate School of Dentistry, Osaka University, Suita 565-0871, Japan.

Publikováno v: International immunology [Int Immunol] 2024 Jan 29; Vol. 36 (1), pp. 33-43.