Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Autor: Zhao, W., Rasheed, A., Tikkanen, E., Lee, J.J., Butterworth, A.S., Howson, J.M.M., Assimes, T.L., Chowdhury, R., Orho-Melander, M., Damrauer, S., Small, A., Asma, S., Imamura, M., Yamauch, T., Chambers, J.C., Chen, P., Sapkota, B.R., Shah, N., Jabeen, S., Surendran, P., Lu, Y.C., Zhang, W.H., Imran, A., Abbas, S., Majeed, F., Trindade, K., Qamar, N., Mallick, N.H., Yaqoob, Z., Saghir, T., Rizvi, S.N.H., Memon, A., Rasheed, S.Z., Memon, F.U.R., Mehmood, K., Ahmed, N., Qureshi, I.H., Tanveer-us-Salam, Iqbal, W., Malik, U., Mehra, N., Kuo, J.Z., Sheu, W.H.H., Guo, X.Q., Hsiung, C.A., Juang, J.M.J., Taylor, K.D., Hung, Y.J., Lee, W.J., Quertermous, T., Lee, I.T., Hsu, C.C., Bottinger, E.P., Ralhan, S., Teo, Y.Y., Wang, T.D., Alam, D.S., Angelantonio, E. di, Epstein, S., Nielsen, S.F., Nordestgaard, B.G., Tybjaerg-Hansen, A., Young, R., Benn, M., Frikke-Schmidt, R., Kamstrup, P.R., Biobank, M., Jukema, J.W., Sattar, N., Smit, R., Chung, R.H., Liang, K.W., Anand, S., Sanghera, D.K., Ripatti, S., Loos, R.J.F., Kooner, J.S., Tai, E.S., Rotter, J.I., Chen, Y.D.I., Frossard, P., Maeda, S., Kadowaki, T., Reilly, M., Pare, G., Melander, O., Salomaa, V., Rader, D.J., Danesh, J., Voight, B.F., Saleheen, D., CHD Exome Consortium, EPIC-CVD Consortium, EPIC-Interact Consortium

Publikováno v: Nature Genetics, 49(10), 1450
Nature genetics
Nature genetics, vol 49, iss 10

Danish Saleheen, Benjamin Voight and colleagues perform genome-wide analysis of multi-ancestry cohorts to identify genetic associations with type 2 diabetes (T2D) and coronary heart disease (CHD). They find novel loci and show that 24% of T2D loci ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3caa34b8b3ba5e80982419c873b247
http://hdl.handle.net/1887/114868

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Autor: Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Tikkanen E; Department of Public Health, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Lee JJ; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Butterworth AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Howson JMM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Orho-Melander M; Department of Clinical Sciences, Lund University, Malmö, Sweden., Damrauer S; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Small A; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Asma S; Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada., Imamura M; Laboratory for Endocrinology, Metabolism, and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan., Yamauch T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK., Chen P; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore., Sapkota BR; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Shah N; Center for Non-Communicable Diseases, Karachi, Pakistan.; Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan., Jabeen S; Center for Non-Communicable Diseases, Karachi, Pakistan., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Lu Y; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Ealing Hospital NHS Trust, Southall, UK., Imran A; Center for Non-Communicable Diseases, Karachi, Pakistan., Abbas S; Faisalabad Institute of Cardiology, Faisalabad, Pakistan., Majeed F; Center for Non-Communicable Diseases, Karachi, Pakistan., Trindade K; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Qamar N; National Institute of Cardiovascular Disorders, Karachi, Pakistan., Mallick NH; Punjab Institute of Cardiology, Lahore, Pakistan., Yaqoob Z; National Institute of Cardiovascular Disorders, Karachi, Pakistan., Saghir T; National Institute of Cardiovascular Disorders, Karachi, Pakistan., Rizvi SNH; National Institute of Cardiovascular Disorders, Karachi, Pakistan., Memon A; National Institute of Cardiovascular Disorders, Karachi, Pakistan., Rasheed SZ; Karachi Institute of Heart Diseases, Karachi, Pakistan., Memon FU; Red Crescent Institute of Cardiology, Hyderabad, Pakistan., Mehmood K; Department of Medicine, Civil Hospital, Karachi, Pakistan., Ahmed N; Department of Neurology, Liaquat National Hospital, Karachi, Pakistan., Qureshi IH; Department of Medicine, Mayo Hospital and King Edward Medical University, Lahore, Pakistan., Tanveer-Us-Salam; Department of Neurology, Lahore General Hospital, Lahore, Pakistan., Iqbal W; Department of Neurology, Lahore General Hospital, Lahore, Pakistan., Malik U; Department of Medicine, Mayo Hospital and King Edward Medical University, Lahore, Pakistan., Mehra N; All-India Institute of Medical Sciences, New Delhi, India., Kuo JZ; Clinical and Medical Affairs, CardioDx, Inc., Redwood City, California, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Sheu WH; Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan, and Chung Shan Medical University, Taichung, Taiwan., Guo X; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Hsiung CA; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Juang JJ; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan., Taylor KD; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Hung YJ; Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan., Quertermous T; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Lee IT; Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan, and Chung Shan Medical University, Taichung, Taiwan., Hsu CC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Ralhan S; Hero DMC Heart Institute Ludhiana, Punjab, India., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.; Genome Institute of Singapore, A*STAR, Singapore.; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore., Wang TD; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan., Alam DS; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Epstein S; MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA., Nielsen SF; Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tybjaerg-Hansen A; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Young R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Benn M; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Frikke-Schmidt R; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Kamstrup PR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Smit R; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Liang KW; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan., Anand S; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada., Sanghera DK; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Oklahoma Center for Neuroscience, Oklahoma City, Oklahoma, USA., Ripatti S; Department of Public Health, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Kooner JS; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Chen YI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA., Frossard P; Center for Non-Communicable Diseases, Karachi, Pakistan., Maeda S; Laboratory for Endocrinology, Metabolism, and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Reilly M; Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA., Pare G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Melander O; Department of Clinical Sciences, Lund University, Malmö, Sweden.; Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Rader DJ; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Danesh J; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Voight BF; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan.

Publikováno v: Nature genetics [Nat Genet] 2017 Oct; Vol. 49 (10), pp. 1450-1457. Date of Electronic Publication: 2017 Sep 04.