Výsledky vyhledávání - "Yamato Tsushima"

Development of G-quadruplex ligands for selective induction of a parallel-type topology

Autor: Yue Ma, Shogo Sasaki, Yamato Tsushima, Mai Sakuma, Sachiko Okabe, Kazuo Nagasawa, Takatsugu Hirokawa, Keisuke Iida, Hiroyuki Seimiya

Publikováno v: Organic & Biomolecular Chemistry. 16:7375-7382

G-Quadruplex structures (G4s) in guanine-rich regions of DNA play critical roles in various biological phenomena, including replication, translation, and gene expression. The G4-forming DNAs can form three kinds of topologies, i.e., parallel, anti-pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08e33feae448879cefd64d30da11215
https://doi.org/10.1039/c8ob01702f

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Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole

Autor: Yue Ma, Yamato Tsushima, Tomomi Yokoyama, Keisuke Iida, Wataru Yoshida, Shadi Sedghi Masoud, Mai Sakuma, Kazuo Nagasawa, Kazunori Ikebukuro

Publikováno v: Bioorganicmedicinal chemistry. 27(8)

G-quadruplexes (G4s) are non-B DNA structures present in guanine-rich regions of gene regulatory areas, promoters and CpG islands, but their occurrence and functions remain incompletely understood. Thus, methodology to identify G4 sequences is needed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebf4f9bebeaaed1723bed55d7b061dd
https://pubmed.ncbi.nlm.nih.gov/30842030

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Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with an ability to induce distinct G-quadruplex topologies in telomeric DNA

Autor: Keisuke Iida, Yamato Tsushima, Mai Sakuma, Yue Ma, Kazuo Nagasawa, Takatsugu Hirokawa

Publikováno v: Organicbiomolecular chemistry. 14(22)

New macrocyclic hexaoxazole compounds bearing two side chains on an unsymmetrical macrocyclic ring system, i.e., 4,2-L2H2-6OTD (2) and 5,1-L2H2-6OTD (3), were designed as candidate G-quadruplex (G4) ligands and synthesized. These G4 ligands 2 and 3 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae29f0c11d13b0461f43a792e10669e2
https://pubmed.ncbi.nlm.nih.gov/27181296

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Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes

Autor: Keisuke Iida, Anton Granzhan, Adrien Marchand, Yue Ma, Valérie Gabelica, Marie-Paule Teulade-Fichou, Kazuo Nagasawa, Yamato Tsushima

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2015, 137 (2), pp.750-756. ⟨10.1021/ja5099403⟩
Journal of the American Chemical Society, 2015, 137 (2), pp.750-756. ⟨10.1021/ja5099403⟩

International audience; The rational design of ligands targeting human telomeric DNA G‐q uadruplexes is a complex problem due to the structural polymorphism that these sequences can adopt in physiological conditions. Moreover, the ability of ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af27d0865e04349d1c127958acdef9f7
https://hal.archives-ouvertes.fr/hal-01524156

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Akademický článek

Ligand-Induced Conformational Changes with Cation Ejection upon Binding to Human Telomeric DNA G-Quadruplexes.

Autor: Marchand, Adrien, Granzhan, Anton, Keisuke Iida, Yamato Tsushima, Yue Ma, Kazuo Nagasawa, Teulade-Fichou, Marie-Paule, Gabelica, Valérie

Publikováno v: Journal of the American Chemical Society; 1/21/2015, Vol. 137 Issue 2, p750-756, 7p

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Akademický článek

Late Mesozoic–Cenozoic Stages of Volcanism and Geodynamics of the Sea of Japan and Sea of Okhotsk.

Autor: Emelyanova, T. A.¹ (AUTHOR) emelyanova@poi.dvo.ru, Petrishchevsky, A. M.² (AUTHOR), Izosov, L. A.¹ (AUTHOR), Lee, N. S.¹ (AUTHOR), Pugachev, A. A.¹ (AUTHOR)

Publikováno v: Petrology. Sep2020, Vol. 28 Issue 5, p418-430. 13p.

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