Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

Autor: Nguyenla X; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, 94720, USA., Wehri E; The Henry Wheeler Center for Emerging and Neglected Diseases, 344 Li Ka Shing, Berkeley, CA, 94720, USA., Van Dis E; Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, 94720, USA., Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, 94720, USA., Yamashiro LH; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, 94720, USA.; Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, 94720, USA., Zhu C; Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA., Stroumza J; The Henry Wheeler Center for Emerging and Neglected Diseases, 344 Li Ka Shing, Berkeley, CA, 94720, USA., Dugast-Darzacq C; Department of Molecular and Cell Biology, Division of Genetics, Genomics and Development, University of California, Berkeley, CA, 94720, USA., Graham TGW; Department of Molecular and Cell Biology, Division of Genetics, Genomics and Development, University of California, Berkeley, CA, 94720, USA., Wang X; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Jockusch S; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemistry, Columbia University, New York, NY, 10027, USA., Tao C; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Chien M; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Xie W; Laboratory of Structural Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA., Patel DJ; Laboratory of Structural Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA., Meyer C; Laboratory of RNA Molecular Biology, Rockefeller University, New York, NY, 10065, USA., Garzia A; Laboratory of RNA Molecular Biology, Rockefeller University, New York, NY, 10065, USA., Tuschl T; Laboratory of RNA Molecular Biology, Rockefeller University, New York, NY, 10065, USA., Russo JJ; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA., Ju J; Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.; Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA.; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, 10032, USA., Näär AM; Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, 94720, USA., Stanley S; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, CA, 94720, USA. sastanley@berkeley.edu.; Department of Molecular and Cell Biology, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, 94720, USA. sastanley@berkeley.edu., Schaletzky J; The Henry Wheeler Center for Emerging and Neglected Diseases, 344 Li Ka Shing, Berkeley, CA, 94720, USA. jschaletzky@berkeley.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Nov 02; Vol. 12 (1), pp. 18506. Date of Electronic Publication: 2022 Nov 02.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

Autor: Biering SB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Sarnik SA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Wang E; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Zengel JR; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Leist SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sathyan V; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Hawkins P; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Okuda K; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Tau C; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Jangid AR; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Duffy CV; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Wei J; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Gilmore RC; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Alfajaro MM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Strine MS; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Nguyenla X; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA., Van Dis E; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Catamura C; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Yamashiro LH; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Belk JA; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Begeman A; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Stark JC; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, CA, USA., Shon DJ; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, CA, USA., Fox DM; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Ezzatpour S; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Huang E; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Olegario N; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rustagi A; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA., Volmer AS; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Livraghi-Butrico A; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wehri E; The Henry Wheeler Center for Emerging and Neglected Diseases, Berkeley, CA, USA., Behringer RR; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cheon DJ; Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, USA., Schaletzky J; The Henry Wheeler Center for Emerging and Neglected Diseases, Berkeley, CA, USA., Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA., Puschnik AS; Chan Zuckerberg Biohub, San Francisco, CA, USA., Button B; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pinsky BA; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Blish CA; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., O'Neal WK; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bertozzi CR; Department of Chemistry and Stanford ChEM-H, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Wilen CB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Boucher RC; Marsico Lung Institute and Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Stanley SA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA. eharris@berkeley.edu., Konermann S; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA. silvanak@stanford.edu.; Arc Institute, Palo Alto, CA, USA. silvanak@stanford.edu., Hsu PD; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu.; Arc Institute, Palo Alto, CA, USA. pdhsu@berkeley.edu.

Publikováno v: Nature genetics [Nat Genet] 2022 Aug; Vol. 54 (8), pp. 1078-1089. Date of Electronic Publication: 2022 Jul 25.

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.

Autor: Yamashiro LH; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA, 94720, USA., Wilson SC; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.; Bristol Myers Squibb, 200 Cambridge Park Dr, Cambridge, MA, 02140, USA., Morrison HM; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA., Karalis V; Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA., Chung JJ; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA., Chen KJ; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA., Bateup HS; Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA., Szpara ML; Departments of Biology and Biochemistry & Molecular Biology, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, PA, 16801, USA., Lee AY; Cancer Research Laboratory, University of California, Berkeley, CA, 94720, USA., Cox JS; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.; Henry Wheeler Center for Emerging and Neglected Diseases, University of California, Berkeley, CA, 94720, USA., Vance RE; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA. rvance@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, 94720, USA. rvance@berkeley.edu.; Cancer Research Laboratory, University of California, Berkeley, CA, 94720, USA. rvance@berkeley.edu.; Henry Wheeler Center for Emerging and Neglected Diseases, University of California, Berkeley, CA, 94720, USA. rvance@berkeley.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 07; Vol. 11 (1), pp. 3382. Date of Electronic Publication: 2020 Jul 07.

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra.

Autor: Ji DX; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Yamashiro LH; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Chen KJ; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Mukaida N; Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan., Kramnik I; The National Emerging Infectious Diseases Laboratory, Department of Medicine (Pulmonary Center), and Department of Microbiology, Boston University School of Medicine, Boston, MA, USA., Darwin KH; Department of Microbiology, New York University School of Medicine, New York, NY, USA., Vance RE; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. rvance@berkeley.edu.; Cancer Research Laboratory, University of California, Berkeley, CA, USA. rvance@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. rvance@berkeley.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2128-2135. Date of Electronic Publication: 2019 Oct 14.

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis.

Autor: Soares FS; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Amaral FC; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Silva NLC; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Valente MR; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Santos LKR; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Yamashiro LH; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Scheffer MC; Microbiology Laboratory, University Hospital, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Castanheira FVES; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Ferreira RG; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Gehrke L; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Alves-Filho JC; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Silva LP; Embrapa Genetic Resources and Biotechnology, Brasilia, Brazil.; Institute of Biological Sciences, University of Brasilia, Brasilia, Brazil., Báfica A; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.; Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil., Spiller F; Laboratory of Immunobiology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.; Department of Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Dec 22; Vol. 8, pp. 1890. Date of Electronic Publication: 2017 Dec 22 (Print Publication: 2017).