Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids.

Autor: Sagi K; Pharmaceutical Research Laboratories, Ajinomoto Company Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681, Japan., Nakagawa T, Yamanashi M, Makino S, Takahashi M, Takayanagi M, Takenaka K, Suzuki N, Oono S, Kataoka N, Ishikawa K, Shima S, Fukuda Y, Kayahara T, Takehana S, Shima Y, Tashiro K, Yamamoto H, Yoshimoto R, Iwata S, Tsuji T, Sakurai K, Shoji M

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2003 May 08; Vol. 46 (10), pp. 1845-57.